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Executive Functions and Cerebral Small-Vessel Disease

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184 papers 0 to 25 followers A collection of papers describing executive dysfunction (and related dysfunctions of intellective capacity) emerging from age related sub & cortical vasculopathies
Xuefeng Zheng, Ziyun Huang, Yaofeng Zhu, Bingbing Liu, Zhi Chen, Tao Chen, Linju Jia, Yanmei Li, Wanlong Lei
Dopaminergic neuron degeneration is known to give rise to dendrite injury and spine loss of striatal neurons, however, changes of intrastriatal glutamatergic terminals and their synapses after 6-hydroxydopamine (6OHDA)-induced dopamine (DA)-depletion remains controversial. To confirm the effect of striatal DA-depletion on the morphology and protein levels of corticostriatal and thalamostriatal glutamatergic terminals and synapses, immunohistochemistry, immuno-electron microscope (EM), western blotting techniques were performed on Parkinson's disease rat models in this study...
February 4, 2019: Neurochemical Research
Paolo Eusebi, Michele Romoli, Federico Paolini Paoletti, Nicola Tambasco, Paolo Calabresi, Lucilla Parnetti
Levodopa-induced dyskinesias (LID) negatively impact on the quality of life of patients with Parkinson's disease (PD). We assessed the risk factors for LID in a cohort of de-novo PD patients enrolled in the Parkinson's Progression Markers Initiative (PPMI). This retrospective cohort study included all PD patients enrolled in the PPMI cohort. Main outcome was the incidence rate of dyskinesia, defined as the first time the patient reported a non-zero score in the item "Time spent with dyskinesia" of the MDS-UPDRS part IV...
2018: NPJ Parkinson's Disease
YuZhi Shi, ShaoWu Li, Wei Li, Chen Zhang, LiYing Guo, YunZhu Pan, XueMei Zhou, XinGao Wang, Songtao Niu, XueYing Yu, HeFei Tang, Bin Chen, ZaiQiang Zhang
Background and objective: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the best known and the most common monogenic small vessel disease (SVD). Cognitive impairment is an inevitable feature of CADASIL. Total SVD score and global cortical atrophy (GCA) scale were found to be good predictors of poor cognitive performance in community-dwelling adults. We aimed to estimate the association between the total SVD score, GCA scale and the cognitive performance in patients with CADASIL...
2018: Frontiers in Neurology
Karin M E Forsberg, Yingshuang Zhang, Johanna Reiners, Martina Ander, Alexandra Niedermayer, Lubin Fang, Hermann Neugebauer, Jan Kassubek, Istvan Katona, Joachim Weis, Albert C Ludolph, Kelly Del Tredici, Heiko Braak, Deniz Yilmazer-Hanke
White matter lesions (WMLs) are a common manifestation of small vessel disease (SVD) in the elderly population. They are associated with an enhanced risk of developing gait abnormalities, poor executive function, dementia, and stroke with high mortality. Hypoperfusion and the resulting endothelial damage are thought to contribute to the development of WMLs. The focus of the present study was the analysis of the microvascular bed in SVD patients with deep WMLs (DWMLs) by using double- and triple-label immunohistochemistry and immunofluorescence...
November 23, 2018: Acta Neuropathologica Communications
Xingfeng Shao, Samantha J Ma, Marlene Casey, Lina D'Orazio, John M Ringman, Danny J J Wang
PURPOSE: To present a novel MR pulse sequence and modeling algorithm to quantify the water exchange rate (kw ) across the blood-brain barrier (BBB) without contrast, and to evaluate its clinical utility in a cohort of elderly subjects at risk of cerebral small vessel disease (SVD). METHODS: A diffusion preparation module with spoiling of non-Carr-Purcell-Meiboom-Gill signals was integrated with pseudo-continuous arterial spin labeling (pCASL) and 3D gradient and spin echo (GRASE) readout...
December 18, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Mark Duncan Findlay, Jesse Dawson, David Alexander Dickie, Kirsten P Forbes, Deborah McGlynn, Terry Quinn, Patrick B Mark
BACKGROUND: The immediate and longer-term effects of hemodialysis on cerebral circulation, cerebral structure, and cognitive function are poorly understood. METHODS: In a prospective observational cohort study of 97 adults (median age 59 years) receiving chronic hemodialysis, we used transcranial Doppler ultrasound to measure cerebral arterial mean flow velocity (MFV) throughout dialysis. Using a well validated neuropsychological protocol, we assessed cognitive function during and off dialysis and after 12 months of treatment...
January 2019: Journal of the American Society of Nephrology: JASN
Simon Loiodice, Harry Wing Young, Bertrand Rion, Benoît Méot, Pierre Montagne, Anne-Sophie Denibaud, Roselyne Viel, Christophe Drieu La Rochelle
This study aims to investigate the contribution of nigral dopaminergic (DA) cell loss, repeated exposure to DA medication and the combination of both to the development of neuropsychiatric symptoms observed in Parkinson's disease (PD). A bilateral 6-OHDA lesion of the substantia nigra pars compacta (SNc) was performed in rats. A set of animals was repeatedly administered with L-dopa (20 mg/kg/day) and benserazide (5 mg/kg/day) over 10 days starting from day 11 post-lesion. Behavioural testing was performed in week 3 post-lesion: novel object recognition (NOR), elevated plus maze (EPM) social interaction (SI) tests, and amphetamine-induced hyperlocomotion (AIH)...
December 3, 2018: Behavioural Brain Research
Fatma Gargouri, Cécile Gallea, Marie Mongin, Nadya Pyatigorskaya, Romain Valabregue, Claire Ewenczyk, Marie Sarazin, Lydia Yahia-Cherif, Marie Vidailhet, Stéphane Lehéricy
BACKGROUND: Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4). OBJECTIVE: We investigated changes in basal forebrain and their role in cognitive deficits in PD...
December 10, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Shun Zhang, Rui Wang, Guanghui Wang
Parkinson's disease (PD) is the second most common neurodegenerative disease. The characteristic of PD is the progressive degeneration of the dopaminergic (DAergic) neurons in the substantia nigra (SN). DAergic neurons in the SN accumulate black and insoluble membrane structures known as neuromelanin during aging. The oxidation of dopamine (DA) to form neuromelanin generates many o-quinones, including DA o-quinones, aminochrome and 5,6-indolequinone. The focus of this review is to discuss the role of DA oxidation in association with PD...
December 28, 2018: ACS Chemical Neuroscience
Kensuke Toyama, Joshua M Spin, Alicia C Deng, Ting-Ting Huang, Ke Wei, Markus U Wagenhäuser, Takuya Yoshino, Huy Nguyen, Joscha Mulorz, Soumajit Kundu, Uwe Raaz, Matti Adam, Isabel N Schellinger, Ann Jagger, Philip S Tsao
OBJECTIVE: There are currently no effective treatments for the prevention of dementia associated with vascular cognitive impairment. MicroRNAs regulate gene expression at the post-transcriptional level and play key roles in vascular disorders. TNFα (tumor necrosis factor-α) regulates blood-brain barrier breakdown through modification of cerebral tight junctions. Here, we sought key TNFα-responsive microRNAs that might influence blood-brain barrier breakdown via cerebral tight junction disruption in vascular cognitive impairment...
June 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Colin Groot, Carole H Sudre, Frederik Barkhof, Charlotte E Teunissen, Bart N M van Berckel, Sang Won Seo, Sébastien Ourselin, Philip Scheltens, M Jorge Cardoso, Wiesje M van der Flier, Rik Ossenkoppele
OBJECTIVE: To examine the clinical phenotype, gray matter atrophy patterns, and small vessel disease in patients who developed prodromal or probable Alzheimer disease dementia, despite carrying the protective APOE ε2 allele. METHODS: We included 36 β-amyloid-positive (by CSF or PET) APOE ε2 carriers (all ε2/ε3) with mild cognitive impairment or dementia due to Alzheimer disease who were matched for age and diagnosis (ratio 1:2) to APOE ε3 homozygotes and APOE ε4 carriers (70% ε3/ε4 and 30% ε4/ε4)...
November 13, 2018: Neurology
Li Xiong, Susanne J van Veluw, Narimene Bounemia, Andreas Charidimou, Marco Pasi, Gregoire Boulouis, Yael D Reijmer, Anne-Katrin Giese, Sigurros Davidsdottir, Panagiotis Fotiadis, Raffaella Valenti, Grace Riley, Kristin Schwab, Edip M Gurol, Alessandro Biffi, Steven M Greenberg, Anand Viswanathan
Background and Purpose- We aimed to explore the association between presence of cerebral cortical microinfarcts (CMIs) on magnetic resonance imaging and other small-vessel disease neuroimaging biomarkers in cerebral amyloid angiopathy (CAA) and to analyze the role of CMIs on individual cognitive domains and dementia conversion. Methods- Participants were recruited from an ongoing longitudinal research cohort of eligible CAA patients between March 2006 and October 2016. A total of 102 cases were included in the analysis that assessed the relationship of cortical CMIs to CAA neuroimaging markers...
October 2018: Stroke; a Journal of Cerebral Circulation
Sarah Atwi, Arron W S Metcalfe, Andrew D Robertson, Jeremy Rezmovitz, Nicole D Anderson, Bradley J MacIntosh
Cognitive decline is often undetectable in the early stages of accelerated vascular aging. Attentional processes are particularly affected in older adults with white matter hyperintensities (WMH), although specific neurovascular mechanisms have not been elucidated. We aimed to identify differences in attention-related neurofunctional activation and behavior between adults with and without WMH. Older adults with moderate to severe WMH ( n = 18, mean age = 70 years), age-matched adults ( n = 28, mean age = 72), and healthy younger adults ( n = 19, mean age = 25) performed a modified flanker task during multi-echo blood oxygenation level dependent functional magnetic resonance imaging...
2018: Frontiers in Neuroscience
Ivonne Pedroso, Marité Garcia, Enrique Casabona, Lilia Morales, Maria Luisa Bringas, Leslie Pérez, Teresita Rodríguez, Ileana Sosa, Yordanka Ricardo, Arnoldo Padrón, Daniel Amaro
Introduction: Treatment strategies in Parkinson's disease (PD) can improve a patient's quality of life but cannot stop the progression of PD. We are looking for different alternatives that modify the natural course of the disease and recent research has demonstrated the neuroprotective properties of erythropoietin. In Cuba, the Center for Molecular Immunology (CIM) is a cutting edge scientific center where the recombinant form (EPOrh) and recombinant human erythropoietin with low sialic acid (NeuroEPO) are produced...
May 2018: Behavioral Sciences
Dominik Blum, Christian la Fougère, Andrea Pilotto, Walter Maetzler, Daniela Berg, Matthias Reimold, Inga Liepelt-Scarfone
PURPOSE: Cognitive impairment (CI) in Parkinson's disease (PD) is associated with a widespread reduction in cortical glucose metabolism and relative increases in the cerebellum and brainstem as measured using 18 F-fluorodesoxyglucose (FDG) PET. We separately analysed CI-related hypermetabolism and hypometabolism in comparison with neuropsychological test performance and investigated whether increased FDG uptake is a true feature of the disease or a normalization effect. METHODS: The study included 29 subjects (12 patients with PD, 10 patients with PD dementia and 7 healthy controls") who underwent FDG PET and comprehensive neuropsychological testing...
July 14, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Erica J Melief, Jonathan W McKinley, Jonathan Y Lam, Nicole M Whiteley, Alec W Gibson, John F Neumaier, Charles W Henschen, Richard D Palmiter, Nigel S Bamford, Martin Darvas
Parkinson's disease (PD) is primarily associated with the degeneration of midbrain dopamine neurons, but it is now appreciated that pathological processes like Lewy-body inclusions and cell loss affect several other brain regions, including the central lateral (CL) and centromedian/parafascicular (CM/PF) thalamic regions. These thalamic glutamatergic neurons provide a non-cortical excitatory input to the dorsal striatum, a major projection field of dopamine neurons. To determine how thalamostriatal signaling may contribute to cognitive and motor abnormalities found in PD, we used a viral vector approach to generate mice with loss of thalamostriatal glutamate signaling specifically restricted to the dorsal striatum (CAV2Cre - Slc17a6 lox/lox mice)...
2018: NPJ Parkinson's Disease
Christian Lambert, Eva Zeestraten, Owen Williams, Philip Benjamin, Andrew J Lawrence, Robin G Morris, Andrew D Mackinnon, Thomas R Barrick, Hugh S Markus
Sporadic cerebral small vessel disease is an important cause of vascular dementia, a syndrome of cognitive impairment together with vascular brain damage. At post-mortem pure vascular dementia is rare, with evidence of co-existing Alzheimer's disease pathology in 95% of cases. This work used MRI to characterize structural abnormalities during the preclinical phase of vascular dementia in symptomatic small vessel disease. 121 subjects were recruited into the St George's Cognition and Neuroimaging in Stroke study and followed up longitudinally for five years...
2018: NeuroImage: Clinical
Rutger Heinen, Naomi Vlegels, Jeroen de Bresser, Alexander Leemans, Geert Jan Biessels, Yael D Reijmer
Background and purpose: Mechanisms underlying cognitive impairment in patients with small vessel disease (SVD) are still unknown. We hypothesized that cognition is affected by the cumulative effect of multiple SVD-related lesions on brain connectivity. We therefore assessed the relationship between the total SVD burden on MRI, global brain network efficiency, and cognition in memory clinic patients with vascular brain injury. Methods: 173 patients from the memory clinic of the University Medical Center Utrecht underwent a 3 T brain MRI scan (including diffusion MRI sequences) and neuropsychological testing...
2018: NeuroImage: Clinical
Stefan Lc Geijselaers, Simone Js Sep, Miranda T Schram, Martin Pj van Boxtel, Thomas T van Sloten, Jos Op Het Roodt, Ronald Ma Henry, Koen D Reesink, Nicolaas C Schaper, Pieter C Dagnelie, Carla Jh van der Kallen, Geert Jan Biessels, Coen DA Stehouwer
BACKGROUND AND AIMS: Arterial remodelling aims at normalising circumferential wall stress (CWS). Greater CWS in the carotid artery has previously been associated with the prevalence and severity of cerebral small vessel disease, a major cause of ageing-related cognitive decline. Here we test the hypothesis that greater carotid CWS is associated with poorer cognitive performance. METHODS: We studied 722 individuals (60 ± 8 years, 55% men, 42.5% highly educated, blood pressure 137 ± 19/77 ± 11 mmHg, n = 197 with type 2 diabetes) who completed a neuropsychological assessment and underwent vascular ultrasound to measure the intima-media thickness (IMT) and interadventitial diameter (IAD) of the left common carotid artery at a plaque-free site...
September 2018: Atherosclerosis
Kai Wu, Ying Cai
BACKGROUND: Cognitive impairment, significantly reducing processing speed and executive function, is the critical consequence of cerebral small vessel disease (SVD), in which genetic variations have been studied. In this study, we explore the role of SNP43 (G/A) and SNP63 (C/T) polymorphism in the CAPN10 on cognitive impairment process in cerebral SVD. METHODS: Cerebral SVD patients (n = 224) and healthy controls (n = 187) were recruited. The relationship between frequency distribution of SNP43 (G/A) and SNP63 (T/C) genotype and allele in CAPN10 gene, and cognitive impairment was examined...
July 16, 2018: Journal of Clinical Laboratory Analysis
2018-10-01 15:39:58
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