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Canine Cranial Cruciate ligament

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Tom Ichinohe, Nobuo Kanno, Yasuji Harada, Takuya Yogo, Masahiro Tagawa, Satoshi Soeta, Hajime Amasaki, Yasushi Hara
Degenerative cranial cruciate ligament (CCL) rupture is characterized histologically by degenerating extracellular matrix (ECM) and chondroid metaplasia. Here, we describe the progression of chondroid metaplasia and the changes in the expression of ECM components in canine CCL rupture (CCLR). CCLs from 26 stifle joints with CCLR (CCLR group) and normal CCLs from 12 young beagles (control group) were examined histologically and immunohistochemically for expression of type I (COLI), type II (COLII), type III collagen (COLIII) and Sry-type HMG box 9 (SOX9)...
July 2015: Journal of Veterinary Medical Science
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