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12 papers 500 to 1000 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
Jessica C Agnew-Blais, Guilherme V Polanczyk, Andrea Danese, Jasmin Wertz, Terrie E Moffitt, Louise Arseneault
IMPORTANCE: Attention-deficit/hyperactivity disorder (ADHD) is now recognized to occur in adulthood and is associated with a range of negative outcomes. However, less is known about the prospective course of ADHD into adulthood, the risk factors for its persistence, and the possibility of its emergence in young adulthood in nonclinical populations. OBJECTIVE: To investigate childhood risk factors and young adult functioning of individuals with persistent, remitted, and late-onset young adult ADHD...
July 1, 2016: JAMA Psychiatry
Luke J Norman, Christina Carlisi, Steve Lukito, Heledd Hart, David Mataix-Cols, Joaquim Radua, Katya Rubia
IMPORTANCE: Patients with attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) share impaired inhibitory control. However, it is unknown whether impairments are mediated by shared or disorder-specific neurostructural and neurofunctional abnormalities. OBJECTIVE: To establish shared and disorder-specific structural, functional, and overlapping multimodal abnormalities in these 2 disorders through a voxel-based meta-analytic comparison of whole-brain gray matter volume (GMV) and functional magnetic resonance imaging (fMRI) studies of inhibition in patients with ADHD and OCD...
August 1, 2016: JAMA Psychiatry
Eduardo F Gallo, Jonathan Posner
Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by developmentally inappropriate levels of inattention and hyperactivity or impulsivity. The heterogeneity of its clinical manifestations and the differential responses to treatment and varied prognoses have long suggested myriad underlying causes. Over the past decade, clinical and basic research efforts have uncovered many behavioural and neurobiological alterations associated with ADHD, from genes to higher order neural networks...
June 2016: Lancet Psychiatry
Anita Thapar, Miriam Cooper
Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a prevalence of 1·4-3·0%. It is more common in boys than girls. Comorbidity with childhood-onset neurodevelopmental disorders and psychiatric disorders is substantial. ADHD is highly heritable and multifactorial; multiple genes and non-inherited factors contribute to the disorder. Prenatal and perinatal factors have been implicated as risks, but definite causes remain unknown. Most guidelines recommend a stepwise approach to treatment, beginning with non-drug interventions and then moving to pharmacological treatment in those most severely affected...
March 19, 2016: Lancet
Ahmad Ghanizadeh, Behzad Haddad
BACKGROUND: The purpose of this research was to study the effectiveness of the overall dietary intervention rather than a single nutrient on children with attention deficit hyperactivity disorder (ADHD). METHODS: This is a randomized controlled trial conducted at a child psychiatry clinic in Iran. Participants were 106 children and adolescents with ADHD. One group received methylphenidate plus dietary recommendations, while the other group only received methylphenidate...
2015: Annals of General Psychiatry
Terrie E Moffitt, Renate Houts, Philip Asherson, Daniel W Belsky, David L Corcoran, Maggie Hammerle, HonaLee Harrington, Sean Hogan, Madeline H Meier, Guilherme V Polanczyk, Richie Poulton, Sandhya Ramrakha, Karen Sugden, Benjamin Williams, Luis Augusto Rohde, Avshalom Caspi
OBJECTIVE: Despite a prevailing assumption that adult ADHD is a childhood-onset neurodevelopmental disorder, no prospective longitudinal study has described the childhoods of the adult ADHD population. The authors report follow-back analyses of ADHD cases diagnosed in adulthood, alongside follow-forward analyses of ADHD cases diagnosed in childhood, in one cohort. METHOD: Participants belonged to a representative birth cohort of 1,037 individuals born in Dunedin, New Zealand, in 1972 and 1973 and followed to age 38, with 95% retention...
October 2015: American Journal of Psychiatry
John Otasowie, Xavier Castells, Umonoibalo P Ehimare, Clare H Smith
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder of childhood onset, which may persist into adulthood. ADHD has a significant impact on a child's daily life, affecting relationships and academic performance. Its core symptoms include developmentally inappropriate levels of inattention, hyperactivity, and impulsive behaviour. Tricyclic antidepressants (TCAs) are sometimes used as second line of treatment in the reduction of ADHD symptoms in children and adolescents with ADHD...
September 19, 2014: Cochrane Database of Systematic Reviews
Tamir Epstein, Nikolaos A Patsopoulos, Mark Weiser
BACKGROUND: Symptoms of attention deficit hyperactivity disorder (ADHD), diagnosed mainly in children, often persist into adulthood. Adults in this group have a high rate of other psychiatric problems and functional difficulties in a number of key areas such as academic achievement, interpersonal relationships, and employment. Although the usefulness of immediate-release methylphenidate in children has been extensively studied, studies in adults, which are few, demonstrate varying results...
September 18, 2014: Cochrane Database of Systematic Reviews
Narong Maneeton, Benchalak Maneeton, Suthi Intaprasert, Pakapan Woottiluk
BACKGROUND: Some trials have suggested that bupropion, as well as methylphenidate, is beneficial in the treatment of attention-deficit/hyperactivity disorder (ADHD). OBJECTIVES: The purpose of this systematic review was to summarize the efficacy, acceptability, and tolerability of bupropion in comparison with methylphenidate for ADHD treatment. Included studies were randomized controlled trials (RCTs) that compared bupropion and methylphenidate. Clinical studies conducted between January 1991 and January 2014 were reviewed...
2014: Neuropsychiatric Disease and Treatment
B M van Hulst, P de Zeeuw, S Durston
BACKGROUND: Multiple pathway models of attention deficit hyperactivity disorder (ADHD) suggest that this disorder is the behavioural expression of dysfunction in one of several separable brain systems. One such model focuses on the brain systems underlying cognitive control, timing and reward sensitivity. It predicts separable subgroups among individuals with ADHD, with performance deficits in only one of these domains. We used latent class analysis (LCA) to identify subgroups of individuals with ADHD based on their overall pattern of neuropsychological performance, rather than grouping them based on cut-off criteria...
March 2015: Psychological Medicine
Juan D Pedraza, Barbara Coffey
No abstract text is available yet for this article.
August 2013: Journal of Child and Adolescent Psychopharmacology
Jan Haavik, Anne Halmøy, Astri J Lundervold, Ole Bernt Fasmer
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent disorder in adult psychiatry, particularly in out-patient settings. There are no objective, laboratory-based tests that can establish this diagnosis. Present diagnostic criteria for ADHD are formulated primarily according to behavior in childhood, based on age inappropriate and impairing levels of hyperactivity, impulsivity and inattention. Other symptoms, such as mood instability and frustration intolerance, are not included in current criteria for ADHD, but are very prevalent in this patient group...
October 2010: Expert Review of Neurotherapeutics
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