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Dermatology

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23 papers 25 to 100 followers
https://read.qxmd.com/read/29893222/efficacy-and-safety-of-guselkumab-in-patients-with-active-psoriatic-arthritis-a-randomised-double-blind-placebo-controlled-phase-2-study
#1
RANDOMIZED CONTROLLED TRIAL
Atul Deodhar, Alice B Gottlieb, Wolf-Henning Boehncke, Bin Dong, Yuhua Wang, Yanli Zhuang, William Barchuk, Xie L Xu, Elizabeth C Hsia
BACKGROUND: Guselkumab, a human monoclonal antibody that binds to the p19 subunit of interleukin 23, has been approved for the treatment of moderate-to-severe psoriasis. Psoriatic arthritis is a common comorbidity of psoriasis with an umet need for novel treatments. We assessed the efficacy and safety of guselkumab in patients with active psoriatic arthritis. METHODS: We did a randomised, double-blind, placebo-controlled, phase 2a trial at 34 rheumatology and dermatology practices in Canada, Germany, Poland, Romania, Russia, Spain, and the USA...
June 2, 2018: Lancet
https://read.qxmd.com/read/29610923/psoriasis
#2
Mark Lebwohl
Psoriasis, an inherited disorder of the immune system, presents most commonly in the skin and joints but is also associated with cardiovascular, metabolic, and neuropsychiatric effects. Treatments include topical therapy for mild disease; phototherapy and oral therapy, such as retinoids and immunomodulating agents; and targeted biologic therapies that have revolutionized treatment of psoriasis and psoriatic arthritis. Primary care physicians should be aware of the systemic associations of psoriasis and the treatments available for this disorder...
April 3, 2018: Annals of Internal Medicine
https://read.qxmd.com/read/30499246/2018-american-college-of-rheumatology-national-psoriasis-foundation-guideline-for-the-treatment-of-psoriatic-arthritis
#3
Jasvinder A Singh, Gordon Guyatt, Alexis Ogdie, Dafna D Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J Mease, Joseph F Merola, Julie Miner, Christopher T Ritchlin, Bernadette Siaton, Benjamin J Smith, Abby S Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C Coates, Alice Gottlieb, Marina Magrey, W Benjamin Nowell, Ana-Maria Orbai, Soumya M Reddy, Jose U Scher, Evan Siegel, Michael Siegel, Jessica A Walsh, Amy S Turner, James Reston
OBJECTIVE: To develop an evidence-based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF). METHODS: We identified critical outcomes in PsA and clinically relevant PICO (population/intervention/comparator/outcomes) questions. A Literature Review Team performed a systematic literature review to summarize evidence supporting the benefits and harms of available pharmacologic and nonpharmacologic therapies for PsA...
November 30, 2018: Arthritis & Rheumatology
https://read.qxmd.com/read/29893226/the-pathogenesis-of-psoriatic-arthritis
#4
REVIEW
Douglas J Veale, Ursula Fearon
Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with inflammation of the joints and entheses, including those of the axial skeleton, and is associated with increased mortality from cardiovascular disease. Diagnosis is primarily based on clinical phenotype because of the diversity of the associated features, which can include skin and nail disease, dactylitis, uveitis, and osteitis. Improved understanding of the pathogenesis of psoriatic arthritis has led to the development of effective biologics and small-molecular drugs targeting specific cytokines and signalling pathways, which can prevent disease progression and improve quality of life...
June 2, 2018: Lancet
https://read.qxmd.com/read/29336054/the-eaaci-ga%C3%A2-len-edf-wao-guideline-for-the-definition-classification-diagnosis-and-management-of-urticaria
#5
T Zuberbier, W Aberer, R Asero, A H Abdul Latiff, D Baker, B Ballmer-Weber, J A Bernstein, C Bindslev-Jensen, Z Brzoza, R Buense Bedrikow, G W Canonica, M K Church, T Craig, I V Danilycheva, C Dressler, L F Ensina, A Giménez-Arnau, K Godse, M Gonçalo, C Grattan, J Hebert, M Hide, A Kaplan, A Kapp, C H Katelaris, E Kocatürk, K Kulthanan, D Larenas-Linnemann, T A Leslie, M Magerl, P Mathelier-Fusade, R Y Meshkova, M Metz, A Nast, E Nettis, H Oude-Elberink, S Rosumeck, S S Saini, M Sánchez-Borges, P Schmid-Grendelmeier, P Staubach, G Sussman, E Toubi, G A Vena, C Vestergaard, B Wedi, R N Werner, Z Zhao, M Maurer
This evidence- and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on 1 December 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF) and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies...
July 2018: Allergy
https://read.qxmd.com/read/25939958/oral-cyclosporine-weekend-therapy-a-new-maintenance-therapeutic-option-in-patients-with-severe-atopic-dermatitis
#6
Cristina Garrido Colmenero, Gonzalo Blasco Morente, Jesús Tercedor Sánchez
Cyclosporine A (CyA) is a systemic therapy used to control severe atopic dermatitis (AD) in children, but its use may be associated with serious side effects. Intermittent short-course therapy has been used to minimize these risks without the loss of clinical benefits. We conducted a 20-week study using intermittent short-course CyA therapy in five patients with severe AD and a Scoring Atopic Dermatitis (SCORAD) score >40. The result was a reduction in the cumulative dose of CyA and serum CyA level, which allows for a longer duration of CyA treatment and decreases the risk of relapse in patients with severe AD...
July 2015: Pediatric Dermatology
https://read.qxmd.com/read/27804089/topical-treatment-of-facial-seborrheic-dermatitis-a-systematic-review
#7
REVIEW
Aditya K Gupta, Sarah G Versteeg
BACKGROUND: Facial seborrheic dermatitis (SD), a chronic inflammatory skin condition, can impact quality of life, and relapses can be frequent. Three broad categories of agents are used to treat SD: antifungal agents, keratolytics, and corticosteroids. Topical therapies are the first line of defense in treating this condition. OBJECTIVE: Our objective was to critically review the published literature on topical treatments for facial SD. METHODS: We searched PubMed, Scopus, Clinicaltrials...
April 2017: American Journal of Clinical Dermatology
https://read.qxmd.com/read/26179009/european-society-of-contact-dermatitis-guideline-for-diagnostic-patch-testing-recommendations-on-best-practice
#8
Jeanne D Johansen, Kristiina Aalto-Korte, Tove Agner, Klaus E Andersen, Andreas Bircher, Magnus Bruze, Alicia Cannavó, Ana Giménez-Arnau, Margarida Gonçalo, An Goossens, Swen M John, Carola Lidén, Magnus Lindberg, Vera Mahler, Mihály Matura, Thomas Rustemeyer, Jørgen Serup, Radoslaw Spiewak, Jacob P Thyssen, Martine Vigan, Ian R White, Mark Wilkinson, Wolfgang Uter
The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement...
October 2015: Contact Dermatitis
https://read.qxmd.com/read/25720544/poor-adherence-to-medication-as-assessed-by-the-morisky-medication-adherence-scale-8-and-low-satisfaction-with-treatment-in-237-psoriasis-patients
#9
Hidehisa Saeki, Shinichi Imafuku, Masatoshi Abe, Yoichi Shintani, Daisuke Onozuka, Akihito Hagihara, Norito Katoh, Hiroyuki Murota, Satoshi Takeuchi, Makoto Sugaya, Miki Tanioka, Sakae Kaneko, Koji Masuda, Takaaki Hiragun, Naoko Inomata, Yuki Kitami, Yuichiro Tsunemi, Shinya Abe, Miwa Kobayashi, Donald E Morisky, Masutaka Furue
Previously we assessed the medication adherence for oral and topical remedies by a translated Japanese version of the Morisky Medication Adherence Scale-8 (MMAS-8) together with socioeconomic backgrounds in 3096 Japanese dermatological patients, and found the medication adherence, especially to topical drugs, was poor in these patients. In order to elucidate the disease-specific sociomedical factors, we further sub-analyzed the medication adherence in 237 psoriasis patients and compared it with that in other dermatological diseases such as atopic dermatitis, urticaria or tinea...
April 2015: Journal of Dermatology
https://read.qxmd.com/read/24726477/engineered-autologous-cartilage-tissue-for-nasal-reconstruction-after-tumour-resection-an-observational-first-in-human-trial
#10
Ilario Fulco, Sylvie Miot, Martin D Haug, Andrea Barbero, Anke Wixmerten, Sandra Feliciano, Francine Wolf, Gernot Jundt, Anna Marsano, Jian Farhadi, Michael Heberer, Marcel Jakob, Dirk J Schaefer, Ivan Martin
BACKGROUND: Autologous native cartilage from the nasal septum, ear, or rib is the standard material for surgical reconstruction of the nasal alar lobule after two-layer excision of non-melanoma skin cancer. We assessed whether engineered autologous cartilage grafts allow safe and functional alar lobule restoration. METHODS: In a first-in-human trial, we recruited five patients at the University Hospital Basel (Basel, Switzerland). To be eligible, patients had to be aged at least 18 years and have a two-layer defect (≥50% size of alar subunit) after excision of non-melanoma skin cancer on the alar lobule...
July 26, 2014: Lancet
https://read.qxmd.com/read/25708973/methylisothiazolinone-in-rinse-off-products-causes-allergic-contact-dermatitis-a-repeated-open-application-study
#11
RANDOMIZED CONTROLLED TRIAL
K Yazar, M D Lundov, A Faurschou, M Matura, A Boman, J D Johansen, C Lidén
BACKGROUND: In recent years, the prevalence of contact allergy to the preservative methylisothiazolinone (MI) has increased dramatically. Cosmetic products are one of the major sources of exposure. OBJECTIVES: To examine whether allowed concentrations of MI in cosmetic rinse-off products have the potential to cause allergic contact dermatitis. METHODS: Nineteen MI-allergic subjects and 19 controls without MI allergy applied two liquid hand soaps five times per day on areas of 5 × 10 cm(2) on the ventral side of their forearms...
July 2015: British Journal of Dermatology
https://read.qxmd.com/read/25708878/additional-review-of-mohs-slides-to-optimize-mohs-micrographic-surgery
#12
C B van Lee, B Graafland, S Koljenović, H A M Neumann, K Nasserinejad, T E C Nijsten, R R van den Bos, K Munte
BACKGROUND: One significant risk factor for recurrence after Mohs surgery is misinterpretation of slides. OBJECTIVES: To determine how often pathologists detected incompletely excised basal cell carcinoma (BCC) on Mohs slides and to determine risk factors for incompletely excised BCCs. METHODS: This retrospective study included 1653 BCCs treated with Mohs surgery in a university hospital between 2007 and 2011. For routine quality assurance, all slides were additionally reviewed by a pathologist within 1 week of the procedure...
July 2015: British Journal of Dermatology
https://read.qxmd.com/read/25708589/merkel-cell-carcinoma-showing-regression-after-biopsy-evaluation-of-programmed-cell-death-1-positive-cells
#13
Noriki Fujimoto, Gen Nakanishi, Miho Kabuto, Toshiaki Nakano, Hikaru Eto, Hideki Nakajima, Shigetoshi Sano, Toshihiro Tanaka
We present a cases of Merkel cell carcinoma (MCC) with Merkel cell polyomavirus that showed complete regression after biopsy. The exact mechanism of regression in MCC has remained unclear. It has been reported that apoptosis caused by T-cell immunity was implicated in the regression, and programmed cell death 1 (PD-1), an inhibitory receptor, was expressed in approximately half of tumor-infiltrating T cells in MCC. However, the contribution of PD-1-positive cells for the regression of MCC has not been evaluated...
May 2015: Journal of Dermatology
https://read.qxmd.com/read/24187141/acne-and-its-management
#14
REVIEW
S Alison Basak, Andrea L Zaenglein
No abstract text is available yet for this article.
November 2013: Pediatrics in Review
https://read.qxmd.com/read/25708520/pemphigoid-with-antibodies-to-laminin-%C3%AE-1-bp180-and-bp230-associated-with-psoriasis-vulgaris-successful-disease-control-with-cyclosporin
#15
Akiko Imanishi, Chiharu Tateishi, Hisayoshi Imanishi, Junko Sowa-Osako, Hiroshi Koga, Daisuke Tsuruta, Takashi Hashimoto
Both anti-laminin γ1 pemphigoid and bullous pemphigoid are autoimmune subepidermal blistering diseases. The former is rare and characterized by autoantibodies to laminin γ1, a 200-kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP180 and BP230, both of which are hemidesmosomal proteins. We experienced a 69-year-old Japanese male patient with blister formation secondary to erythrodermic psoriasis, which was successfully treated with cyclosporin. The histopathology of erythema corresponded with psoriasis and that of a blistering lesion showed infiltration of neutrophils and eosinophils in and around the subepidermal blisters...
April 2015: Journal of Dermatology
https://read.qxmd.com/read/22980258/congenital-melanocytic-nevi-where-are-we-now-part-i-clinical-presentation-epidemiology-pathogenesis-histology-malignant-transformation-and-neurocutaneous-melanosis
#16
REVIEW
Ali Alikhan, Omar A Ibrahimi, Daniel B Eisen
Congenital melanocytic nevi (CMN) are present at birth or arise during the first few weeks of life. They are quite common, may have a heritable component, and can present with marked differences in size, shape, color, and location. Histologic and dermatoscopic findings may help suggest the diagnosis, but they are not entirely specific. CMN are categorized based on size, and larger lesions can have a significant psychosocial impact and other complications. They are associated with a variety of dermatologic lesions, ranging from benign to malignant...
October 2012: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/20523108/effect-of-topical-application-of-virgin-coconut-oil-on-skin-components-and-antioxidant-status-during-dermal-wound-healing-in-young-rats
#17
K G Nevin, T Rajamohan
OBJECTIVES: The present study was undertaken to evaluate the effect of a topical application of virgin coconut oil (VCO) on excision wounds in young rats. METHODS: Three sets of experiments with 3 groups of female Sprague-Dawley rats each consisting of 6 animals were used for studying wound closure time, antioxidant status and biochemical parameters. Group 1 was the control; groups 2 and 3 were treated with 0.5 and 1.0 ml VCO, respectively, 24 h after wound creation for 10 days...
2010: Skin Pharmacology and Physiology
https://read.qxmd.com/read/23237497/pemphigoid-diseases
#18
REVIEW
Enno Schmidt, Detlef Zillikens
Pemphigoid diseases are a group of well defined autoimmune disorders that are characterised by autoantibodies against structural proteins of the dermal-epidermal junction and, clinically, by tense blisters and erosions on skin or mucous membranes close to the skin surface. The most common of these diseases is bullous pemphigoid, which mainly affects older people and the reported incidence of which in Europe has more than doubled in the past decade. Prognosis and treatments vary substantially between the different disorders and, since clinical criteria are usually not sufficient, direct immunofluorescence microscopy of a perilesional biopsy specimen or serological tests are needed for exact diagnosis...
January 26, 2013: Lancet
https://read.qxmd.com/read/25690725/toxic-epidermal-necrolysis-triggered-by-clobazam-a-case-report-in-a-13-year-old-girl
#19
Chuong D Dang, Linda Beets-Shay, Estelle C Kahn
We present a case of toxic epidermal necrolysis (TEN) triggered by clobazam in a 13-year-old girl who was subsequently treated with intravenous immunoglobulin. In December 2013 the U.S. Food and Drug Administration released a warning that clobazam might cause "serious skin reactions" such as Stevens-Johnson syndrome or TEN and approved label changes.
May 2015: Pediatric Dermatology
https://read.qxmd.com/read/25690369/pigmented-purpuric-dermatosis-clinicopathologic-characterization-in-a-pediatric-series
#20
Jérôme Coulombe, Sara-Elizabeth Jean, Afshin Hatami, Julie Powell, Danielle Marcoux, Victor Kokta, Catherine McCuaig
Pigmentary purpuras (PPs) are a group of chronic disorders of unknown origin seldom described in children. With this study we sought to better characterize PP eruptions, including clinical evolution and management. A retrospective chart review from 2003 to 2013 querying characteristics of children with a biopsy-proven diagnosis of PP in the Centre Hospitalier Universitaire Ste-Justine dermatology clinic (Montreal, Quebec, Canada) was performed. Follow-up was obtained through telephone interviews. Descriptive statistical analysis was used...
May 2015: Pediatric Dermatology
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