Benjamin J D Weist, Patrizia Wehler, Linda El Ahmad, Michael Schmueck-Henneresse, Jason M Millward, Mikalai Nienen, Avidan U Neumann, Petra Reinke, Nina Babel
Reactivation of Polyomavirus BKV is a severe complication in kidney transplant patients. Current treatment requires close monitoring, and modification of immunosuppressive drugs. As an important additional tool, the monitoring of BKV immunity has been based on detection of cytokine-secreting T cells upon BKV-antigen challenge. However, low frequent BKV-specific T cells are often barely detectable and their roles in BKV clearance remain unclear. Here, we analyzed the effects of immunosuppressive agents on BKV-specific T cells in vitro...
December 2015: Kidney International