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Borderline personality disorder

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14 papers 500 to 1000 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
Gordon Parker, Adam Bayes, Georgia McClure, Yolanda Romàn Ruiz Del Moral, Janine Stevenson
BACKGROUND: The status and differentiation of comorbid borderline personality disorder and bipolar disorder is worthy of clarification. AIMS: To determine whether comorbid borderline personality disorder and bipolar disorder are interdependent or independent conditions. METHOD: We interviewed patients diagnosed with either a borderline personality disorder and/or a bipolar condition. RESULTS: Analyses of participants grouped by DSM diagnoses established that those with comorbid conditions scored similarly to those with a borderline personality disorder alone on all key variables (i...
September 2016: British Journal of Psychiatry: the Journal of Mental Science
Laura E Müller, André Schulz, Martin Andermann, Andrea Gäbel, Dorothee Maria Gescher, Angelika Spohn, Sabine C Herpertz, Katja Bertsch
IMPORTANCE: The ability to perceive and regulate one's own emotions has been tightly linked to the processing of afferent bodily signals (interoception). Thus, disturbed interoception might contribute to the core feature of emotional dysregulation in borderline personality disorder (BPD), as increased levels of depersonalization, body image disturbances, and reduced sensitivity to physical pain suggest poor body awareness in BPD. OBJECTIVE: To determine neural correlates of disturbed body awareness in BPD and its associations with emotional dysregulation and to explore improvements in body awareness with BPD symptom remission...
November 2015: JAMA Psychiatry
Sabine C Herpertz, Katja Bertsch
Borderline personality disorder is characterized by three domains of dysfunction: affect dysregulation, behavioral dyscontrol, and interpersonal hypersensitivity. Interpersonal hypersensitivity is associated with a (pre)attentive bias toward negative social information and, on the level of the brain, enhanced bottom-up emotion generation, while affect dysregulation results from abnormal top-down processes. Additionally, the problems of patients with borderline personality disorder in interpersonal functioning appear to be related to alterations in the (social) reward and empathy networks...
September 1, 2015: American Journal of Psychiatry
Robert S Biskin
Borderline personality disorder (BPD) has historically been seen as a lifelong, highly disabling disorder. Research during the past 2 decades has challenged this assumption. This paper reviews the course of BPD throughout life, including childhood, adolescence, and adulthood. BPD can be accurately identified in adolescence, and the course of the disorder, in adolescence and adulthood, is generally similar, with reductions in symptoms over time. Functional recovery is less consistent, and further research on factors or treatments that may improve the long-term functional outcome of patients with BPD is warranted...
July 2015: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Sarah Reitz, Rosemarie Kluetsch, Inga Niedtfeld, Teresa Knorz, Stefanie Lis, Christian Paret, Peter Kirsch, Andreas Meyer-Lindenberg, Rolf-Detlef Treede, Ulf Baumgärtner, Martin Bohus, Christian Schmahl
BACKGROUND: Patients with borderline personality disorder frequently show non-suicidal self-injury (NSSI). In these patients, NSSI often serves to reduce high levels of stress. AIMS: Investigation of neurobiological mechanisms of NSSI in borderline personality disorder. METHOD: In total, 21 women with borderline personality disorder and 17 healthy controls underwent a stress induction, followed by either an incision into the forearm or a sham treatment...
August 2015: British Journal of Psychiatry: the Journal of Mental Science
Marsha M Linehan, Kathryn E Korslund, Melanie S Harned, Robert J Gallop, Anita Lungu, Andrada D Neacsiu, Joshua McDavid, Katherine Anne Comtois, Angela M Murray-Gregory
IMPORTANCE: Dialectical behavior therapy (DBT) is an empirically supported treatment for suicidal individuals. However, DBT consists of multiple components, including individual therapy, skills training, telephone coaching, and a therapist consultation team, and little is known about which components are needed to achieve positive outcomes. OBJECTIVE: To evaluate the importance of the skills training component of DBT by comparing skills training plus case management (DBT-S), DBT individual therapy plus activities group (DBT-I), and standard DBT which includes skills training and individual therapy...
May 2015: JAMA Psychiatry
Mauricio Tohen
No abstract text is available yet for this article.
November 1, 2014: American Journal of Psychiatry
S Nassir Ghaemi, Shannon Dalley
OBJECTIVE: This review aims to address concerns about the potential overinclusiveness and vagueness of bipolar spectrum concepts, and also, concerns about the overlap between bipolar illness and borderline personality. METHOD: Narrative review based on historical and empirical studies. RESULTS: Bipolar disorder (BD) and major depressive disorder (MDD) came to be separate entities with the Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM III), in contrast to the Kraepelinian manic-depressive insanity (MDI) concept, which included both...
April 2014: Australian and New Zealand Journal of Psychiatry
Aisling O'Neill, Arun D'Souza, Andrea C Samson, Angela Carballedo, Christian Kerskens, Thomas Frodl
Individuals with borderline personality disorder (BPD) commonly display deficits in emotion regulation, but findings in the area of social cognitive (e.g., theory of mind, ToM) capacities have been heterogeneous. The aims of the current study were to investigate differences between patients with BPD and controls in functional connectivity (1) between the emotion and ToM network and (2) in the default mode network (DMN). Functional magnetic resonance imaging was used to investigate 19 healthy controls and 17 patients with BPD at rest and during ToM processing...
January 30, 2015: Psychiatry Research
A Krause-Utz, I M Veer, S A R B Rombouts, M Bohus, C Schmahl, B M Elzinga
BACKGROUND: Studies in borderline personality disorder (BPD) have consistently revealed abnormalities in fronto-limbic brain regions during emotional, somatosensory and cognitive challenges. Here we investigated changes in resting-state functional connectivity (RSFC) of three fronto-limbic core regions of specific importance to BPD. METHOD: Functional magnetic resonance imaging data were acquired in 20 unmedicated female BPD patients and 17 healthy controls (HC, matched for age, sex and education) during rest...
October 2014: Psychological Medicine
Adam Bayes, Gordon Parker, Kathryn Fletcher
PURPOSE OF REVIEW: Differentiating bipolar II disorder (BP II) from borderline personality disorder (BPD) is a common diagnostic dilemma. The purpose of this review is to focus on recent studies that have considered clinical differences between the conditions including family history, phenomenology, longitudinal course, comorbidity and treatment response, and which might advance their clinical distinction. RECENT FINDINGS: Findings suggest key differentiating parameters to include family history, onset pattern, clinical course, phenomenological profile of depressive and elevated mood states, and symptoms of emotional dysregulation...
January 2014: Current Opinion in Psychiatry
Robert S Biskin, Joel Paris
No abstract text is available yet for this article.
November 20, 2012: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
John G Gunderson
No abstract text is available yet for this article.
May 26, 2011: New England Journal of Medicine
Jutta Stoffers, Birgit A Völlm, Gerta Rücker, Antje Timmer, Nick Huband, Klaus Lieb
BACKGROUND: Drugs are widely used in borderline personality disorder (BPD) treatment, chosen because of properties known from other psychiatric disorders ("off-label use"), mostly targeting affective or impulsive symptom clusters. OBJECTIVES: To assess the effects of drug treatment in BPD patients. SEARCH STRATEGY: We searched bibliographic databases according to the Cochrane Developmental, Psychosocial and Learning Problems Group strategy up to September 2009, reference lists of articles, and contacted researchers in the field...
June 16, 2010: Cochrane Database of Systematic Reviews
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