Christiane E Angermann, Götz Gelbrich, Stefan Störk, Hilka Gunold, Frank Edelmann, Rolf Wachter, Heribert Schunkert, Tobias Graf, Ingrid Kindermann, Markus Haass, Stephan Blankenberg, Sabine Pankuweit, Christiane Prettin, Martin Gottwik, Michael Böhm, Hermann Faller, Jürgen Deckert, Georg Ertl
IMPORTANCE: Depression is frequent in patients with heart failure and is associated with adverse clinical outcomes. Long-term efficacy and safety of selective serotonin reuptake inhibitors in these patients are unknown. OBJECTIVE: To determine whether 24 months of treatment with escitalopram improves mortality, morbidity, and mood in patients with chronic systolic heart failure and depression. DESIGN, SETTING, AND PARTICIPANTS: The Effects of Selective Serotonin Re-Uptake Inhibition on Morbidity, Mortality, and Mood in Depressed Heart Failure Patients (MOOD-HF) study was a double-blind, placebo-controlled randomized clinical trial conducted at 16 tertiary medical centers in Germany...
June 28, 2016: JAMA