Mark T Dransfield, Sarah Harnden, Robert L Burton, Richard K Albert, William C Bailey, Richard Casaburi, John Connett, J Allen D Cooper, Gerard J Criner, Jeffrey L Curtis, Meilan K Han, Barry Make, Nathaniel Marchetti, Fernando J Martinez, Charlene McEvoy, Moon H Nahm, Dennis E Niewoehner, Janos Porszasz, John Reilly, Paul D Scanlon, Steven M Scharf, Frank C Sciurba, George R Washko, Prescott G Woodruff, Stephen C Lazarus
BACKGROUND: Although the 23-valent pneumococcal polysaccharide vaccine (PPSV23) protects against invasive disease in young healthy persons, randomized controlled trials in chronic obstructive pulmonary disease (COPD) have demonstrated no benefit in the intention-to-treat population. We previously reported that the 7-valent diphtheria-conjugated pneumococcal polysaccharide vaccine (PCV7) is safe and induced greater serotype-specific immunoglobulin G (IgG) and functional antibody than did PPSV23 1 month after vaccination...
September 2012: Clinical Infectious Diseases