collection
https://read.qxmd.com/read/33539826/stem-cell-secreted-factor-therapy-regenerates-the-ovarian-niche-and-rescues-follicles
#1
JOURNAL ARTICLE
Anna Buigues, María Marchante, Lucia de Miguel-Gómez, Jessica Martinez, Irene Cervelló, Antonio Pellicer, Sonia Herraiz
BACKGROUND: Ovarian senescence is a normal age-associated phenomenon, but increasingly younger women are affected by diminished ovarian reserves or premature ovarian insufficiency. There is an urgent need for developing therapies to improve ovarian function in these patients. In this context, previous studies suggest that stem cell-secreted factors could have regenerative properties in the ovaries. OBJECTIVE: This study aimed to test the ability of various human plasma sources, enriched in stem cell-secreted factors, and the mechanisms behind their regenerative properties, to repair ovarian damage and to promote follicular development...
July 2021: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/32761180/implications-of-nonphysiological-ovarian-primordial-follicle-activation-for-fertility-preservation
#2
REVIEW
Johanne Grosbois, Melody Devos, Isabelle Demeestere
In recent years, ovarian tissue cryopreservation has rapidly developed as a successful method for preserving the fertility of girls and young women with cancer or benign conditions requiring gonadotoxic therapy, and is now becoming widely recognized as an effective alternative to oocyte and embryo freezing when not feasible. Primordial follicles are the most abundant population of follicles in the ovary, and their relatively quiescent metabolism makes them more resistant to cryoinjury. This dormant pool represents a key target for fertility preservation strategies as a resource for generating high-quality oocytes...
December 1, 2020: Endocrine Reviews
https://read.qxmd.com/read/31604663/fertility-preservation-in-gynecologic-cancers
#3
REVIEW
Enes Taylan, Kutluk Oktay
An increasing number of women in modern societies are delaying childbearing beyond the age of 35, and gynecologic cancers affect a significant proportion of reproductive age women who wish to preserve fertility for a future chance of childbearing. As a result, providing treatment options for fertility preservation in women with gynecologic cancer has become a crucial component of cancer survivorship care. In this review article, we discussed the current knowledge on fertility-sparing surgical approaches, as well as assisted reproductive technologies that can be utilized to preserve reproductive potential in women with cervical, endometrial, and ovarian cancer...
December 2019: Gynecologic Oncology
https://read.qxmd.com/read/30396563/autotransplantation-of-fragmented-ovarian-cortical-tissue-a-laparoscopic-demonstration
#4
JOURNAL ARTICLE
Stine Aagaard Lunding, Susanne Elisabeth Pors, Stine Gry Kristensen, Claus Yding Andersen, Janni Vikkelsø Jeppesen, Kirsten Tryde Macklon, Anders Nyboe Andersen, Anette Tønnes Pedersen
OBJECTIVE: To describe and demonstrate a simple and secure procedure for laparoscopic autotransplantation of fragmented ovarian cortical tissue in women with diminished ovarian reserve as part of in vitro activation (IVA) of ovarian follicles. DESIGN: Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique. SETTING: Fertility clinic and obstetrics and gynecology department at a university hospital...
November 2018: Fertility and Sterility
https://read.qxmd.com/read/30670046/maternal-high-fat-diet-impairs-follicular-development-of-offspring-through-intraovarian-kisspeptin-gpr54-system
#5
JOURNAL ARTICLE
Zhiyang Zhou, Qi Lin, Xinxin Xu, Gaby Sukma Illahi, Chenle Dong, Xueqing Wu
BACKGROUND: Excessive gestational weight gain (GWG), which is associated with adverse long-term effects on the health of the offspring, has become a major clinical problem. Accumulating evidence indicates that the ovary kisspeptin/GPR54 system directly participates in a series of physiological activities. We used a model of high-fat diet (HFD) during gestational to investigate offspring's ovarian function and whether kisspeptin/GPR54 system is involved. METHODS: After introducing the male and confirmation of mating by checking a vaginal sperm plug, female rats were randomized into two groups: control diet called NCD group and high-fat diet called HFD group...
January 22, 2019: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/30696098/implications-and-current-limitations-of-oogenesis-from-female-germline-or-oogonial-stem-cells-in-adult-mammalian-ovaries
#6
REVIEW
Jessica J Martin, Dori C Woods, Jonathan L Tilly
A now large body of evidence supports the existence of mitotically active germ cells in postnatal ovaries of diverse mammalian species, including humans. This opens the possibility that adult stem cells naturally committed to a germline fate could be leveraged for the production of female gametes outside of the body. The functional properties of these cells, referred to as female germline or oogonial stem cells (OSCs), in ovaries of women have recently been tested in various ways, including a very recent investigation of the differentiation capacity of human OSCs at a single cell level...
January 28, 2019: Cells
https://read.qxmd.com/read/30779707/resveratrol-alleviates-chemotherapy-induced-oogonial-stem-cell-apoptosis-and-ovarian-aging-in-mice
#7
JOURNAL ARTICLE
Meng Wu, Lingwei Ma, Liru Xue, Wenlei Ye, Zhiyong Lu, Xiang Li, Yan Jin, Xian Qin, Dan Chen, Weicheng Tang, Yingying Chen, Zixin Hong, Jinjin Zhang, Aiyue Luo, Shixuan Wang
Chemotherapy-induced ovarian aging not only increases the risk for early menopause-related complications but also results in infertility in young female cancer survivors. Oogonial stem cells have the ability to generate new oocytes and thus provide new opportunities for treating ovarian aging and female infertility. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural phenol derived from plants, that has been shown to have positive effects on longevity and redox flow in lipid metabolism and a preventive function against certain tumors...
February 14, 2019: Aging
https://read.qxmd.com/read/30118694/prevalence-of-endometrial-cancer-or-atypical-hyperplasia-diagnosed-incidentally-in-infertility-clinic
#8
LETTER
Yusuf Aytac Tohma, Hulusi Bulent Zeyneloglu, Oner Deniz Aslan, Asuman Nihan Haberal, Gogsen Onalan, Ali Ayhan
No abstract text is available yet for this article.
November 2018: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/28719396/preclinical-models-of-ovarian-cancer-pathogenesis-problems-and-implications-for-prevention
#9
REVIEW
Anthony N Karnezis, Kathleen R Cho
Preclinical models are relatively underutilized and underfunded resources for modeling the pathogenesis and prevention of ovarian cancers. Several reviews have detailed the numerous published models of ovarian cancer. In this review, we will provide an overview of experimental model systems, their strengths and limitations, and use selected models to illustrate how they can be used to address specific issues about ovarian cancer pathogenesis. We will then highlight some of the preclinical prevention studies performed to date and discuss experiments needed to address important unanswered questions about ovarian cancer prevention strategies...
December 2017: Clinical Obstetrics and Gynecology
https://read.qxmd.com/read/28270607/mtorc1-2-inhibition-preserves-ovarian-function-and-fertility-during-genotoxic-chemotherapy
#10
JOURNAL ARTICLE
Kara N Goldman, Devon Chenette, Rezina Arju, Francesca E Duncan, David L Keefe, Jamie A Grifo, Robert J Schneider
The ovary contains oocytes within immature (primordial) follicles that are fixed in number at birth. Activation of follicles within this fixed pool causes an irreversible decline in reproductive capacity, known as the ovarian reserve, until menopause. Premenopausal women undergoing commonly used genotoxic (DNA-damaging) chemotherapy experience an accelerated loss of the ovarian reserve, leading to subfertility and infertility. Therefore, there is considerable interest but little effective progress in preserving ovarian function during chemotherapy...
March 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/27281217/towards-clinical-application-of-pronuclear-transfer-to-prevent-mitochondrial-dna-disease
#11
JOURNAL ARTICLE
Louise A Hyslop, Paul Blakeley, Lyndsey Craven, Jessica Richardson, Norah M E Fogarty, Elpida Fragouli, Mahdi Lamb, Sissy E Wamaitha, Nilendran Prathalingam, Qi Zhang, Hannah O'Keefe, Yuko Takeda, Lucia Arizzi, Samer Alfarawati, Helen A Tuppen, Laura Irving, Dimitrios Kalleas, Meenakshi Choudhary, Dagan Wells, Alison P Murdoch, Douglass M Turnbull, Kathy K Niakan, Mary Herbert
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range of debilitating and fatal diseases. Reproductive technologies designed to uncouple the inheritance of mtDNA from nuclear DNA may enable affected women to have a genetically related child with a greatly reduced risk of mtDNA disease. Here we report the first preclinical studies on pronuclear transplantation (PNT). Surprisingly, techniques used in proof-of-concept studies involving abnormally fertilized human zygotes were not well tolerated by normally fertilized zygotes...
June 16, 2016: Nature
https://read.qxmd.com/read/26656301/cisplatin-induces-overactivation-of-the-dormant-primordial-follicle-through-pten-akt-foxo3a-pathway-which-leads-to-loss-of-ovarian-reserve-in-mice
#12
JOURNAL ARTICLE
Eun Mi Chang, Eunjin Lim, Sookyoung Yoon, Kyungah Jeong, Sijeong Bae, Dong Ryul Lee, Tae Ki Yoon, Youngsok Choi, Woo Sik Lee
Cisplatin is a first-line chemotherapeutic agent for ovarian cancer that acts by promoting DNA cross links and adduct. However drug resistance and considerable side effects including reproductive toxicity remain a significant challenge. PTEN is well known as a tumor suppressor function which plays a fundamental role in the regulation of the cell cycle, apoptosis and development of cancer. At the same time PTEN has been revealed to be critically important for the maintenance of the primordial follicle pool. In this study, we investigated the role of PTEN/Akt/FOXO3 pathway in cisplatin-induced primordial follicle depletion...
2015: PloS One
https://read.qxmd.com/read/26643302/systematic-reviews-and-meta-analyses-of-benefits-and-harms-of-cryotherapy-leep-and-cold-knife-conization-to-treat-cervical-intraepithelial-neoplasia
#13
REVIEW
Nancy Santesso, Reem A Mustafa, Wojtek Wiercioch, Rohan Kehar, Shreyas Gandhi, Yaolong Chen, Adrienne Cheung, Jessica Hopkins, Rasha Khatib, Bin Ma, Ahmad A Mustafa, Nancy Lloyd, Darong Wu, Nathalie Broutet, Holger J Schünemann
BACKGROUND: Cervical intraepithelial neoplasia (CIN) stage 2-3 is a premalignant lesion that can progress to cervical cancer in 10-20 years if untreated. OBJECTIVES: To conduct systematic reviews of randomized and nonrandomized studies for effects of cryotherapy, loop electrosurgical excision procedure (LEEP), and cold knife conization (CKC) as treatment for CIN 2-3. SEARCH STRATEGY: Medline, Embase, and other databases were searched to February 2012 for benefits, and to July 2012 for harms...
March 2016: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/25361917/molecular-pathways-intercellular-pten-and-the-potential-of-pten-restoration-therapy
#14
REVIEW
Benjamin D Hopkins, Ramon E Parsons
Phosphatase and Tensin homolog deleted on chromosome Ten (PTEN) acts as a tumor suppressor through both PI3K-dependent and -independent mechanisms. Reduced PTEN activity has been shown to affect not only tumor cell proliferation and survival but also the microenvironmental context in which nascent tumors develop. As a result of the multifaceted tumor-suppressive roles of PTEN, tumors evolve by selecting for clones in which PTEN activity is lost. PTEN activity within tumors can be modulated in numerous ways, including direct mutation, epigenetic regulation, and amplification or mutation of other proteins that can regulate or degrade PTEN...
November 1, 2014: Clinical Cancer Research
https://read.qxmd.com/read/25729252/efficacy-of-random-start-controlled-ovarian-stimulation-in-cancer-patients
#15
COMPARATIVE STUDY
Jee Hyun Kim, Seul Ki Kim, Hee Jun Lee, Jung Ryeol Lee, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim
This study aimed to evaluate the efficacy of random-start controlled ovarian stimulation (COS) in cancer patients for emergency fertility preservation. In this retrospective comparative study, 22 patients diagnosed with cancer and 44 infertile women undergoing conventional in vitro fertilization (IVF) were included. In cancer patients, ovarian stimulation was started on the day of referral, irrespective of their menstrual cycle date. The control group was selected by age matching among women undergoing conventional IVF...
March 2015: Journal of Korean Medical Science
https://read.qxmd.com/read/25567618/successful-fertility-preservation-following-ovarian-tissue-vitrification-in-patients-with-primary-ovarian-insufficiency
#16
JOURNAL ARTICLE
Nao Suzuki, Nobuhito Yoshioka, Seido Takae, Yodo Sugishita, Midori Tamura, Shu Hashimoto, Yoshiharu Morimoto, Kazuhiro Kawamura
STUDY QUESTION: Is ovarian tissue cryopreservation using vitrification followed by in vitro activation (IVA) of dormant follicles a potential approach for infertility treatment of patients with primary ovarian insufficiency (POI)? SUMMARY ANSWER: Our vitrification approach followed by IVA treatment is a potential infertility therapy for POI patients whose ovaries contain residual follicles. WHAT IS KNOWN ALREADY: Akt (protein kinase B) stimulators [PTEN (phosphatase with TENsin homology deleted in chromosome 10) inhibitor and phosphatidyinositol-3-kinase (PI3 kinase) stimulator] activate dormant primordial follicles in vitro and ovarian fragmentation disrupts the Hippo signaling pathway, leading to the promotion of follicle growth...
March 2015: Human Reproduction
https://read.qxmd.com/read/26253691/in-vitro-maturation-ivm-of-oocytes-recovered-from-ovariectomy-specimens-in-the-laboratory-a-promising-ex-vivo-method-of-oocyte-cryopreservation-resulting-in-the-first-report-of-an-ongoing-pregnancy-in-europe
#17
JOURNAL ARTICLE
Ingrid Segers, Ileana Mateizel, Ellen Van Moer, Johan Smitz, Herman Tournaye, Greta Verheyen, Michel De Vos
PURPOSE: We present our center's experience with 34 consecutive cases who underwent in vitro maturation (IVM) of oocytes obtained from ovariectomy specimens and compare our data with updated literature data. METHODS: Feasibility and efficiency of oocyte collection during ovarian tissue processing was assessed by the recovery rate, maturation rate, and embryological development after IVM. RESULTS: On average, 14 immature oocytes were retrieved per patient during ovarian tissue processing in 33/34 patients...
August 2015: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/26425730/in-vitro-maturation-and-cryopreservation-of-oocytes-at-the-time-of-oophorectomy
#18
JOURNAL ARTICLE
Melanie L Walls, Kirsty Douglas, John P Ryan, Jason Tan, Roger Hart
A 27 year old female presented for fertility preservation prior to undergoing pelvic radiotherapy. She had previously undergone a radical laparoscopic hysterectomy for cervical carcinoma seven months earlier. A trans-vaginal oocyte aspiration was not advisable due to a vaginal recurrence of the disease. Due to a polycystic ovarian morphology (PCO), follicle stimulating hormone (FSH) priming with no human chorionic gonadotrophin (hCG) trigger was performed prior to oophorectomy followed by ex-vivo oocyte aspiration and in vitro maturation (IVM)...
August 2015: Gynecologic Oncology Reports
https://read.qxmd.com/read/26345687/optimizing-outcomes-from-ovarian-tissue-cryopreservation-and-transplantation-activation-versus-preservation
#19
REVIEW
Dror Meirow, Hadassa Roness, Stine Gry Kristensen, Claus Yding Andersen
Ovarian tissue cryopreservation and transplantation (OTCP) is gaining increasing traction in the field of fertility preservation as a result of accumulated successes. We now have a decade of experience with the technique, with tens of live births and greater than 90% return of ovarian function in graft recipients. Recently, a novel method of OTCP has been described, termed in vitro activated OTCP which proposes significant changes to the standard protocol. This method aims to stimulate activation of dormant follicles within the grafts prior to transplantation and ensure that mature oocytes can be generated in the immediate short term after transplantation...
November 2015: Human Reproduction
https://read.qxmd.com/read/26278808/combination-of-ovarian-tissue-harvesting-and-immature-oocyte-collection-for-fertility-preservation-increases-preservation-yield
#20
JOURNAL ARTICLE
A Hourvitz, G M Yerushalmi, E Maman, H Raanani, S Elizur, M Brengauz, R Orvieto, J Dor, D Meirow
The aim of this study was to evaluate the safety and efficacy of combined ovarian tissue cryopreservation and oocyte aspiration just before ovarian tissue cryobanking. A retrospective cohort study of fertility preservation patients treated in 2007-2013 in one tertiary centre was performed. A total of 255 cancer patients were admitted for fertility preservation: 142 patients underwent ovarian tissue cryopreservation only (OTC), 56 underwent OTC plus oocyte retrieval from ovarian tissue (OTIVM), nine underwent oocyte aspiration and in-vitro maturation (AIVM) and 48 underwent all three procedures...
October 2015: Reproductive Biomedicine Online
label_collection
label_collection
3988
1
2
2015-10-28 20:49:26
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.