Michelle L O'Donoghue, Robert S Rosenson, Baris Gencer, J Antonio G López, Norman E Lepor, Seth J Baum, Elmer Stout, Daniel Gaudet, Beat Knusel, Julia F Kuder, Xinhui Ran, Sabina A Murphy, Huei Wang, You Wu, Helina Kassahun, Marc S Sabatine
BACKGROUND: Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. METHODS: We conducted a randomized, double-blind, placebo-controlled, dose-finding trial involving patients with established atherosclerotic cardiovascular disease and a lipoprotein(a) concentration of more than 150 nmol per liter. Patients were randomly assigned to receive one of four doses of olpasiran (10 mg every 12 weeks, 75 mg every 12 weeks, 225 mg every 12 weeks, or 225 mg every 24 weeks) or matching placebo, administered subcutaneously...
November 17, 2022: New England Journal of Medicine