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55 papers 25 to 100 followers İVF, endometriosis, icsi, infertility
Jessica A Grieger, Luke E Grzeskowiak, Lisa G Smithers, Tina Bianco-Miotto, Shalem Y Leemaqz, Prabha Andraweera, Lucilla Poston, Lesley M McCowan, Louise C Kenny, Jenny Myers, James J Walker, Robert J Norman, Gus A Dekker, Claire T Roberts
OBJECTIVES: To determine 1) the association between metabolic syndrome (MetS), time to pregnancy (TTP), and infertility 2) associations between individual and increasing number of MetS components, TTP, and infertility; 3) whether these relationships differ by obesity (BMI, <30kg/m2 vs. ≥30kg/m2 ). DESIGN: Retrospective cohort study. SETTING: Multi-centre (Australia, United Kingdom, New Zealand, Ireland). POPULATION: 5519 low-risk nulliparous pregnant women...
February 7, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
Marzie Farimani, Safoura Heshmati, Jalal Poorolajal, Maryam Bahmanzadeh
The prevalence of poor response to gonadotropin stimulation is approximately 9-24% in women undergoing in vitro fertilization. Interestingly, due to containing a variety of growth factors, platelet-rich plasma (PRP) can play an important role in tissue regeneration and healing. Thus, in this research, we aimed to investigate the intra-ovarian injection of PRP in women with poor ovarian response. To this goal, 23 poor responders constituted the study population, from among whom 19 women were enrolled. These patients underwent ovarian stimulation according to the Shanghai protocol...
February 5, 2019: Molecular Biology Reports
Yali Liu, Qiuju Chen, Sha Yu, Yun Wang, Wen He, Hannah Ya-Ning Chang, Bian Wang, Hongyuan Gao, Hui Long, Li Wang, Qifeng Lyu, Ai Ai, Yanping Kuang
OBJECTIVE: To compare the endocrinological profiles, cycle characteristics and pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) with or without clomiphene citrate (CC) supplementation in normal ovulatory women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). DESIGN: Prospective randomized controlled study. PATIENT(S): A total of 320 infertile women undergoing IVF/ICSI. Medroxyprogesterone acetate (MPA) and human menopausal gonadotropin (hMG) were simultaneously administered on menstrual cycle day 3...
March 2018: Clinical Endocrinology
Yanett Anaya, Douglas A Mata, Joseph Letourneau, Hakan Cakmak, Marcelle I Cedars, Mitchell P Rosen
PURPOSE: Modification of the trigger used to induce final oocyte maturation in in vitro fertilization (IVF) is a major strategy used to reduce the risk of ovarian hyperstimulation syndrome (OHSS). A novel trigger composed of 1500 IU of human chorionic gonadotropin (hCG) plus 450 IU of follicle-stimulating hormone (FSH) has been developed to reduce OHSS risk. This study compares outcomes of the novel trigger to conventional triggers used in high-risk OHSS patients undergoing IVF. METHODS: In this retrospective cohort study, IVF cycles at high risk for OHSS based on a serum estradiol > 5000 pg/ml on trigger day conducted between January 2008 and February 2016 were evaluated...
February 2018: Journal of Assisted Reproduction and Genetics
Cindy Farquhar, Jane Marjoribanks, Julie Brown, Bart C J M Fauser, Anne Lethaby, Selma Mourad, Robert Rebar, Marian Showell, Sheryl van der Poel
In this paper, a review of evidence provided to the World Health Organization (WHO) guideline development, who prepare global guidance on the management of ovarian stimulation for women undergoing IVF, is presented. The purpose of ovarian stimulation is to facilitate retrieval of multiple oocytes during a single IVF cycle. Availability of multiple oocytes compensates for inefficiencies in subsequent stages of the cycle, which include oocyte maturation, IVF, embryo culture, embryo transfer, and implantation...
July 2017: Reproductive Biomedicine Online
Meixiang Zhang, Wenbin Niu, Yu Wang, Jiawei Xu, Xiao Bao, Linlin Wang, Linqing Du, Yingpu Sun
PURPOSE: We reviewed the influence of dehydroepiandrosterone (DHEA) supplementation in patients with poor ovarian response (POR) undergoing in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI). METHODS: We searched Embase, MEDLINE, PubMed, and the Cochrane Library (1980-2015) for relevant papers and used the Newcastle-Ottawa Scale scoring system to evaluate study quality. Dichotomous data were expressed as pooled relative risk (RR) estimates with fixed or random effect models...
August 2016: Journal of Assisted Reproduction and Genetics
Akmal El-Mazny, Wafaa Ramadan, Ahmed Kamel, Sherine Gad-Allah
OBJECTIVE: To evaluate the effect of hydrosalpinx on uterine and ovarian blood flows in women with tubal factor infertility. STUDY DESIGN: In a cross-sectional study at a university teaching hospital, 60 women with hydrosalpinx-related tubal infertility (hydrosalpinx group) were compared with 60 women with male or unexplained infertility (non-hydrosalpinx group). In the mid-luteal (peri-implantation) phase of the cycle, endometrial thickness, uterine and ovarian artery pulsatility index (PI) and resistance index (RI), and endometrial and ovarian volume and 3D power Doppler vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were measured in both groups...
April 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Mesut Oktem, Ismail Guler, Mehmet Erdem, Ahmet Erdem, Nuray Bozkurt, Onur Karabacak
BACKGROUND: Our objective was to evaluate the effectiveness of clomiphene citrate (CC) vs. letrozole (L) plus human menopausal gonadotropin (hMG) in gonadotropin releasing hormone (GnRH) antagonist protocol in poor prognosis women with previous failed ovarian stimulation undergoing intracytoplasmic sperm injection (ICSI). MATERIALS AND METHODS: This retrospective cohort study included cycles with CC and L plus hMG/GnRH antagonist protocols of 32 poor responders who had failed to have ideal follicles to be retrieved during oocyte pick-up (OPU) or embryo transfer (ET) at least for 2 previous in vitro fertilization (IVF) cycles with microdose flare protocol or GnRH antagonist protocol from January 2006 to December 2009...
October 2015: International Journal of Fertility & Sterility
Anderson Sanches Melo, Rui Alberto Ferriani, Paula Andrea Navarro
Polycystic ovary syndrome represents 80% of anovulatory infertility cases. Treatment initially includes preconception guidelines, such as lifestyle changes (weight loss), folic acid therapy to prevent the risk of fetal neural tube defects and halting the consumption of tobacco and alcohol. The first-line pharmacological treatment for inducing ovulation consists of a clomiphene citrate treatment for timed intercourse. The second-line pharmacological treatment includes the administration of exogenous gonadotropins or laparoscopic ovarian surgery (ovarian drilling)...
November 2015: Clinics
Elias M Dahdouh, Jacques Balayla, Juan Antonio García-Velasco
OBJECTIVE: To study whether preimplantation genetic screening with comprehensive chromosome screening (PGS-CCS) improves clinical implantation rates (IR) and sustained IR (beyond 20 weeks) compared with routine care for embryo selection in IVF cycles. DESIGN: Meta-analysis of randomized controlled trials (RCTs) and observational studies (OSs). SETTING: University-affiliated teaching hospital. PATIENT(S): Infertile couples undergoing IVF...
December 2015: Fertility and Sterility
Thorir Hardarson, Mona Bungum, Joe Conaghan, Marius Meintjes, Samuel J Chantilis, Laszlo Molnar, Kristina Gunnarsson, Matts Wikland
OBJECTIVE: To study whether a culture medium that allows undisturbed culture supports human embryo development to the blastocyst stage equivalently to a well-established sequential media. DESIGN: Randomized, double-blinded sibling trial. SETTING: Independent in vitro fertilization (IVF) clinics. PATIENT(S): One hundred twenty-eight patients, with 1,356 zygotes randomized into two study arms. INTERVENTION(S): Embryos randomly allocated into two study arms to compare embryo development on a time-lapse system using a single-step medium or sequential media...
December 2015: Fertility and Sterility
Lydia Luley, Anne Schumacher, Melissa J Mulla, Dirk Franke, Michael Löttge, Sara Fill Malfertheiner, Svetlana N Tchaikovski, Serban-Dan Costa, Berthold Hoppe, Vikki M Abrahams, Ana C Zenclussen
PROBLEM: Thrombophilia is associated with pregnancy complications. Treatment with low molecular weight heparin (LMWH) improves pregnancy outcome, but the underlying mechanisms are not clear. METHODS OF STUDY: We analyzed Treg frequency in blood from thrombophilic pregnancies treated with LMWH (n = 32) or untreated (n = 33) and from healthy pregnancies (n = 39) at all trimesters. Additionally, we treated pregnant wild-type, heterozygous and homozygous factor-V-Leiden (FVL) mice with LMWH or PBS and determined Treg frequency, pro-/anti-inflammatory cytokine levels and Caspase-3-activity in placenta and decidua...
May 2015: American Journal of Reproductive Immunology: AJRI
Song Dan, Wang Wei, Shi Yichao, Cheng Hongbo, Yang Shenmin, Wang Jiaxiong, Li Hong
The effects of prednisolone on pregnancy outcome are open to debate. This meta-analysis was performed to evaluate the efficiency of prednisolone administration on unexplained recurrent miscarriage (RM) and the process of assisted reproductive technology (ART). Relevant publications were searched from databases and the included randomized controlled trials (RCTs) investigated effects of prednisolone administration in women with unexplained RM or during ART. The outcomes in our analysis were measured in terms of risk ratios (RRs) with 95% confidence intervals (CI) using random effect models...
July 2015: American Journal of Reproductive Immunology: AJRI
Uma Thiruchelvam, Mary Wingfield, Cliona O'Farrelly
Endometriosis affects more than 10% of women, causing significant pain and morbidity. It is also a significant cause of infertility. The aetiology of the disease remains an enigma, and the mechanisms responsible for the associated infertility are unclear. A role for immune cells in endometriosis has been postulated, with attention directed towards natural killer (NK) cells and macrophages. NK cells kill tumours and infected cells but also have roles in tissue remodelling in several organs including the uterus and are key to successful pregnancy...
October 2015: American Journal of Reproductive Immunology: AJRI
Stefano Palomba, Marlieke A de Wilde, Angela Falbo, Maria P H Koster, Giovanni Battista La Sala, Bart C J M Fauser
BACKGROUND: The great majority of studies performed so far concerning women diagnosed with polycystic ovary syndrome (PCOS) have focused on diagnosis, menstrual cycle abnormalities, hirsutism and infertility. Although progress has been made in developing methods for achieving a pregnancy and reducing multiple gestations in women with PCOS, little attention has been paid to pregnancy complications and subsequent child outcomes. This review aims to summarize current knowledge regarding the clinical and pathophysiological features of pregnancy and children in women with PCOS...
September 2015: Human Reproduction Update
Deepak Kumar, Edward Springel, Robert M Moore, Brian M Mercer, Elliot Philipson, Joseph M Mansour, Sam Mesiano, Fredrick Schatz, Charles J Lockwood, John J Moore
OBJECTIVE: Inflammation/infection and abruption are leading causes of preterm premature rupture of the membranes. Recently, we identified granulocyte-macrophage colony-stimulating factor (GM-CSF) as a critical mediator of both tumor necrosis factor-α- (TNF; modeling inflammation) and thrombin-induced (modeling abruption) weakening of the fetal membranes. We found that (1) TNF and thrombin both induced GM-CSF in the choriodecidua, (2) blockade of GM-CSF action with neutralizing antibodies inhibited both TNF- and thrombin-induced fetal membrane weakening, and (3) GM-CSF alone induced fetal membrane weakening...
October 2015: American Journal of Obstetrics and Gynecology
Ali Abbara, Channa N Jayasena, Georgios Christopoulos, Shakunthala Narayanaswamy, Chioma Izzi-Engbeaya, Gurjinder M K Nijher, Alexander N Comninos, Deborah Peters, Adam Buckley, Risheka Ratnasabapathy, Julia K Prague, Rehan Salim, Stuart A Lavery, Stephen R Bloom, Matyas Szigeti, Deborah A Ashby, Geoffrey H Trew, Waljit S Dhillo
CONTEXT: In vitro fertilization (IVF) treatment is an effective therapy for infertility, but can result in the potentially life-threatening complication, ovarian hyperstimulation syndrome (OHSS). OBJECTIVE: This study aimed to investigate whether kisspeptin-54 can be used to effectively and safely trigger oocyte maturation in women undergoing IVF treatment at high risk of developing OHSS. SETTING AND DESIGN: This was a phase 2, multi-dose, open-label, randomized clinical trial of 60 women at high risk of developing OHSS carried out during 2013-2014 at Hammersmith Hospital IVF unit, London, United Kingdom...
September 2015: Journal of Clinical Endocrinology and Metabolism
Adi Hirshberg, Lorraine Dugoff
First-trimester ultrasound provides valuable information to help optimize the management of multifetal pregnancies. First trimester ultrasound the use of ultrasound and screening for aneuploidy has been well studied in singleton pregnancies. While evidence supporting the use of ultrasound in multiple gestations is well established, aneuploidy screening continues to evolve and its role in the prenatal setting has been less well studied. We review the importance of early first trimester ultrasound in assessing gestational age and chorionicity and early identification of anomalies, and review the various methods and limitations of aneuploidy screening and invasive diagnostic procedures in multiples...
September 2015: Clinical Obstetrics and Gynecology
Ramón Estruch, Emilio Ros, Jordi Salas-Salvadó, Maria-Isabel Covas, Dolores Corella, Fernando Arós, Enrique Gómez-Gracia, Valentina Ruiz-Gutiérrez, Miquel Fiol, José Lapetra, Rosa Maria Lamuela-Raventos, Lluís Serra-Majem, Xavier Pintó, Josep Basora, Miguel Angel Muñoz, José V Sorlí, José Alfredo Martínez, Miguel Angel Martínez-González
BACKGROUND: Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events. METHODS: In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat)...
April 4, 2013: New England Journal of Medicine
Auke B C Otten, Hubert J M Smeets
BACKGROUND: The endosymbiosis of an alpha-proteobacterium and a eubacterium a billion years ago paved the way for multicellularity and enabled eukaryotes to flourish. The selective advantage for the host was the acquired ability to generate large amounts of intracellular hydrogen-dependent adenosine triphosphate. The price was increased reactive oxygen species (ROS) inside the eukaryotic cell, causing high mutation rates of the mitochondrial DNA (mtDNA). According to the Muller's ratchet theory, this accumulation of mutations in asexually transmitted mtDNA would ultimately lead to reduced reproductive fitness and eventually extinction...
September 2015: Human Reproduction Update
2015-05-29 10:22:11
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