collection
https://read.qxmd.com/read/36211982/traumatic-brain-injury-and-secondary-neurodegenerative-disease
#21
JOURNAL ARTICLE
William S Dodd, Eric J Panther, Kevin Pierre, Jairo S Hernandez, Devan Patel, Brandon Lucke-Wold
Traumatic brain injury (TBI) is a devastating event with severe long-term complications. TBI and its sequelae are one of the leading causes of death and disability in those under 50 years old. The full extent of secondary brain injury is still being intensely investigated; however, it is now clear that neurotrauma can incite chronic neurodegenerative processes. Chronic traumatic encephalopathy, Parkinson's disease, and many other neurodegenerative syndromes have all been associated with a history of traumatic brain injury...
December 2022: Trauma Care (Basel)
https://read.qxmd.com/read/35937061/applying-the-bradford-hill-criteria-for-causation-to-repetitive-head-impacts-and-chronic-traumatic-encephalopathy
#22
REVIEW
Christopher J Nowinski, Samantha C Bureau, Michael E Buckland, Maurice A Curtis, Daniel H Daneshvar, Richard L M Faull, Lea T Grinberg, Elisa L Hill-Yardin, Helen C Murray, Alan J Pearce, Catherine M Suter, Adam J White, Adam M Finkel, Robert C Cantu
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with a history of repetitive head impacts (RHI). CTE was described in boxers as early as the 1920s and by the 1950s it was widely accepted that hits to the head caused some boxers to become "punch drunk." However, the recent discovery of CTE in American and Australian-rules football, soccer, rugby, ice hockey, and other sports has resulted in renewed debate on whether the relationship between RHI and CTE is causal. Identifying the strength of the evidential relationship between CTE and RHI has implications for public health and medico-legal issues...
2022: Frontiers in Neurology
https://read.qxmd.com/read/35769361/chronic-traumatic-encephalopathy-as-a-preventable-environmental-disease
#23
JOURNAL ARTICLE
Michael E Buckland, Andrew J Affleck, Alan J Pearce, Catherine M Suter
In this Perspective we explore the evolution of our understanding of chronic traumatic encephalopathy (CTE) and its relationship with repetitive head injury. As with many neurodegenerative conditions, there is an imperfect correspondence between neuropathology and clinical phenotype, but unlike other neurodegenerative diseases, CTE has a discrete and easily modifiable risk factor: exposure to repetitive head injury. Consequently, evaluation of the evidence regarding exposure to repetitive head injury and CTE risk should be undertaken using public or occupational health frameworks of medical knowledge...
2022: Frontiers in Neurology
https://read.qxmd.com/read/35328293/post-concussion-syndrome-and-chronic-traumatic-encephalopathy-narrative-review-on-the-neuropathology-neuroimaging-and-fluid-biomarkers
#24
REVIEW
Ioannis Mavroudis, Dimitrios Kazis, Rumana Chowdhury, Foivos Petridis, Vasiliki Costa, Ioana-Miruna Balmus, Alin Ciobica, Alina-Costina Luca, Iulian Radu, Romeo Petru Dobrin, Stavros Baloyannis
Traumatic brain injury is a significant public health issue and represents the main contributor to death and disability globally among all trauma-related injuries. Martial arts practitioners, military veterans, athletes, victims of physical abuse, and epileptic patients could be affected by the consequences of repetitive mild head injuries (RMHI) that do not resume only to short-termed traumatic brain injuries (TBI) effects but also to more complex and time-extended outcomes, such as post-concussive syndrome (PCS) and chronic traumatic encephalopathy (CTE)...
March 18, 2022: Diagnostics
https://read.qxmd.com/read/34839696/cumulative-concussion-and-odds-of-stroke-in-former-national-football-league-players
#25
JOURNAL ARTICLE
Benjamin L Brett, Zachary Y Kerr, Neelum T Aggarwal, Avinash Chandran, Rebekah Mannix, Samuel Walton, J D DeFreese, Ruben J Echemendia, Kevin M Guskiewicz, Michael A McCrea, William P Meehan
BACKGROUND AND PURPOSE: Postmortem and experimental studies indicate a potential association between repeated concussions and stroke risk in older contact sport athletes. We examined the relationship between concussion and stroke history in former National Football League players aged ≥50 years. METHODS: Former professional football players aged ≥50 years who played ≥1 year in the National Football League were enrolled in the cross-sectional study. Indirect standardization was used to calculate overall and decade-specific standardized prevalence ratios...
January 2022: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/34707552/predictors-and-correlates-of-perceived-cognitive-decline-in-retired-professional-rugby-league-players
#26
JOURNAL ARTICLE
Ryan Van Patten, Grant L Iverson, Douglas P Terry, Christopher R Levi, Andrew J Gardner
Objective: Rugby league is an international full-contact sport, with frequent concussive injuries. Participation in other full-contact sports such as American football has been considered to be a risk factor for neuropsychiatric sequelae later-in-life, but little research has addressed the mental and cognitive health of retired professional rugby league players. We examined predictors and correlates of perceived (self-reported) cognitive decline in retired National Rugby League (NRL) players. Methods: Participants were 133 retired male elite level rugby league players in Australia...
2021: Frontiers in Neurology
https://read.qxmd.com/read/34674184/mortality-risk-from-neurodegenerative-disease-in-sports-associated-with-repetitive-head-impacts-preliminary-findings-from-a-systematic-review-and-meta-analysis
#27
Javier S Morales, Pedro L Valenzuela, Gonzalo Saco-Ledo, Adrián Castillo-García, Cristina S Carabias, Paul McCrory, Alejandro Santos-Lozano, Alejandro Lucia
BACKGROUND: Professional athletes seem to have a lower overall mortality risk than the general population, but controversy exists about whether athletes in sports associated with repetitive head impacts have a higher risk of mortality from neurodegenerative diseases. OBJECTIVE: We aimed to determine the risk of mortality from neurodegenerative diseases in sports associated with repeated head impacts compared with the general population or compared with athletes with no such exposure...
October 21, 2021: Sports Medicine
https://read.qxmd.com/read/34593716/mild-cognitive-impairment-and-dementia-reported-by-former-professional-football-players-over-50-yr-of-age-an-nfl-long-study
#28
JOURNAL ARTICLE
Samuel R Walton, Benjamin L Brett, Avinash Chandran, J D Defreese, Rebekah Mannix, Ruben J Echemendia, William P Meehan, Michael McCrea, Kevin M Guskiewicz, Zachary Y Kerr
PURPOSE: This study aimed to estimate prevalence of mild cognitive impairment (MCI) and dementia diagnoses in former National Football League (NFL) players ≥50 yr old and examine the relationships among these diagnoses and an array of predictors of long-term brain health. METHODS: A cross section of former NFL players (n = 922; mean ± SD age, 64.8 ± 8.9 yr) completed a questionnaire. Prevalence of self-reported medical diagnoses of MCI and dementia was reported alongside U...
March 1, 2022: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/34022959/identifying-degenerative-effects-of-repetitive-head-trauma-with-neuroimaging-a-clinically-oriented-review
#29
REVIEW
Breton M Asken, Gil D Rabinovici
BACKGROUND AND SCOPE OF REVIEW: Varying severities and frequencies of head trauma may result in dynamic acute and chronic pathophysiologic responses in the brain. Heightened attention to long-term effects of head trauma, particularly repetitive head trauma, has sparked recent efforts to identify neuroimaging biomarkers of underlying disease processes. Imaging modalities like structural magnetic resonance imaging (MRI) and positron emission tomography (PET) are the most clinically applicable given their use in neurodegenerative disease diagnosis and differentiation...
May 22, 2021: Acta Neuropathologica Communications
https://read.qxmd.com/read/33935940/examining-the-research-criteria-for-traumatic-encephalopathy-syndrome-in-middle-aged-men-from-the-general-population-who-played-contact-sports-in-high-school
#30
JOURNAL ARTICLE
Grant L Iverson, Zachary C Merz, Douglas P Terry
Objective: There are no validated or agreed upon diagnostic clinical criteria for chronic traumatic encephalopathy or traumatic encephalopathy syndrome. This study examines the leading research criteria for traumatic encephalopathy syndrome (TES) in middle-aged men in the general population. Method: Participants were 409 men between the ages of 35 and 55 recruited through an online crowdsourcing platform. Participants provided demographic information, medication history, concussion history, contact sport history, current medication use, and current symptoms...
2021: Frontiers in Neurology
https://read.qxmd.com/read/33767661/chronic-neurophysiological-effects-of-repeated-head-trauma-in-retired-australian-male-sport-athletes
#31
JOURNAL ARTICLE
Alan J Pearce, Dawson J Kidgell, Mark A Tommerdahl, Ashlyn K Frazer, Billymo Rist, Rowena Mobbs, Jennifer Batchelor, Michael E Buckland
Aim: This study investigated the somatosensory and corticomotor physiology of retired contact sport athletes with a history of repeated concussion/subconcussion head trauma. Methods: Retired male athletes with a history of playing contact sports and repeated head trauma ( n = 122) were divided into two groups: those who expressed concerns regarding their mental and cognitive health ("symptomatic": n = 83), and those who did not express any ongoing concerns ("asymptomatic": n = 39). Both groups were compared to age-matched male controls ( n = 50) with no history of concussions or participation in contact sports, an absence of self-reported cognitive, or mood impairments...
2021: Frontiers in Neurology
https://read.qxmd.com/read/33721207/diffusion-weighted-imaging-in-mild-traumatic-brain-injury-a-systematic-review-of-the-literature
#32
REVIEW
Hannah M Lindsey, Cooper B Hodges, Kaitlyn M Greer, Elisabeth A Wilde, Tricia L Merkley
There is evidence that diffusion-weighted imaging (DWI) is able to detect tissue alterations following mild traumatic brain injury (mTBI) that may not be observed on conventional neuroimaging; however, findings are often inconsistent between studies. This systematic review assesses patterns of differences in DWI metrics between those with and without a history of mTBI. A PubMed literature search was performed using relevant indexing terms for articles published prior to May 14, 2020. Findings were limited to human studies using DWI in mTBI...
March 15, 2021: Neuropsychology Review
https://read.qxmd.com/read/33708171/frequency-and-predictors-of-traumatic-encephalopathy-syndrome-in-a-prospective-cohort-of-retired-professional-athletes
#33
JOURNAL ARTICLE
Jeff Schaffert, Nyaz Didehbani, Christian LoBue, John Hart, Heidi Rossetti, Laura Lacritz, C Munro Cullum
Traumatic encephalopathy syndrome (TES) is proposed to represent the long-term impact of repetitive head-injury exposure and the clinical manifestation of chronic traumatic encephalopathy (CTE). This study aimed to evaluate the frequency of TES in a cohort of retired professional contact sport athletes, compare the frequency of TES to clinical consensus diagnoses, and identify predictors that increase the likelihood of TES diagnosis. Participants were 85 retired professional contact sport athletes from a prospective cohort at the University of Texas Southwestern Medical Center and the University of Texas at Dallas...
2021: Frontiers in Neurology
https://read.qxmd.com/read/33627496/association-of-position-played-and-career-duration-and-chronic-traumatic-encephalopathy-at-autopsy-in-elite-football-and-hockey-players
#34
JOURNAL ARTICLE
Nicole Schwab, Richard Wennberg, Karl Grenier, Carmela Tartaglia, Charles Tator, Lili-Naz Hazrati
OBJECTIVE: To determine whether an association exists between career duration or position played and the presence of chronic traumatic encephalopathy (CTE) at autopsy in a series of elite football and hockey players. METHODS: This retrospective cohort study analyzed post-mortem brains of 35 former football or hockey players (29 professional, 6 university varsity/major junior), with the presence of CTE at autopsy as the primary outcome. Position played (highest level), age at retirement (indicator of lifetime exposure to sport), and hockey fighting/penalization histories (surrogate marker for role/style of play) were collected...
February 24, 2021: Neurology
https://read.qxmd.com/read/33621530/chronic-traumatic-encephalopathy
#35
REVIEW
J Hugon, C Hourregue, E Cognat, M Lilamand, B Porte, F Mouton-Liger, J Dumurgier, C Paquet
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repeated traumatic brain injury (TBI). This disorder is mainly observed in subjects at risk for brain traumatisms including boxers, American football and European football (soccer) players, as well as war veterans. Neuropathological findings are marked by abnormally phosphorylated tau accumulations at the depth of cerebral sulci, as well as TDP43, Aβ and α-synuclein positive staining. It has been described 3 clinical variants: the behavioural/mood variant, the cognitive variant and the mixed behavioural/cognitive variant...
May 2021: Neuro-Chirurgie
https://read.qxmd.com/read/33498520/severe-suicidality-in-athletes-with-chronic-traumatic-encephalopathy-a-case-series-and-overview-on-putative-ethiopathogenetic-mechanisms
#36
Alessandra Costanza, Michalina Radomska, Francesco Zenga, Andrea Amerio, Andrea Aguglia, Gianluca Serafini, Mario Amore, Isabella Berardelli, Yasutaka Ojio, Khoa D Nguyen
Chronic traumatic encephalopathy (CTE) results from repetitive brain injuries and is a common neurotraumatic sequela in contact sports. CTE is often accompanied by neuropsychiatric symptoms, which could escalate to suicidal ideation (SI) and suicidal behaviour (SB). Nevertheless, fairly limited emphasis about the association between suicidality and CTE exists in medical literature. Here, we report two cases of retired professional athletes in high contact sports (boxing and ice hockey) who have developed similar clinical trajectories characterized by progressive neuropsychiatric symptoms compatible with a CTE diagnosis and subsequent SB in its severe forms (medical serious suicide attempt (SA) and completed suicide)...
January 20, 2021: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/33483350/distinct-latent-profiles-based-on-neurobehavioural-physical-and-psychosocial-functioning-of-former-national-football-league-nfl-players-an-nfl-long-study
#37
JOURNAL ARTICLE
Benjamin L Brett, Samuel R Walton, Zachery Y Kerr, Lindsay D Nelson, Avinash Chandran, J D Defreese, Ruben J Echemendia, Kevin M Guskiewicz, William P Meehan Iii, Michael A McCrea
OBJECTIVE: To identify subgroups of former National Football League (NFL) players using latent profile analysis (LPA) and examine their associations with total years of participation (TYP) and self-reported lifetime sport-related concussion history (SR-CHx). METHODS: Former NFL players (N=686) aged 50-70 years, with an average 18.0 TYP (±4.5) completed a questionnaire. SR-CHx distributions included: low (0-3; n=221); intermediate (4-8; n=209) and high (9+; n=256)...
March 2021: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/33188135/not-all-adverse-health-outcomes-in-former-contact-sports-athletes-are-concussion-related
#38
EDITORIAL
Emma R Russell, Thomas McCabe, William Stewart
No abstract text is available yet for this article.
March 2021: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/32788258/concussion-symptomology-and-recovery-in-children-and-adolescents-with-pre-existing-anxiety
#39
JOURNAL ARTICLE
Alexia K Martin, Ashley J Petersen, Heather W Sesma, Mary B Koolmo, Katherine M Ingram, Katie B Slifko, Victoria N Nguyen, Robert C Doss, Amy M Linabery
OBJECTIVE: To examine pre-existing anxiety disorders as a risk factor for increased concussion symptomology and prolonged recovery in children and adolescents. METHODS: In this retrospective cohort study, we abstracted medical record data for 637 children/adolescents (5-17 years) presenting to three tertiary concussion clinics between April 2018 and March 2019. Primary outcomes were mean concussion symptom and vision symptom severity scores measured at clinic visits...
October 2020: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/32789487/pathophysiologic-mechanisms-of-concussion-development-of-chronic-traumatic-encephalopathy-and-emerging-diagnostics-a-narrative-review
#40
JOURNAL ARTICLE
James A D Berry, Christopher Elia, Raed Sweiss, Shokry Lawandy, Ira Bowen, Bailey Zampella, Harneel Saini, James Brazdzionis, Dan Miulli
Pathophysiological mechanisms and cascades take place after a mild traumatic brain injury (mTBI) that can cause long-term sequelae, including chronic traumatic encephalopathy in patients with multiple concurrent TBIs. As diagnostic imaging has become more advanced, microanatomical changes present after mTBI may now be more readily visible. In this narrative review, the authors discuss emerging diagnostics and findings in mTBI through advanced imaging, electroencephalograms, neurophysiologic processes, Q2 biochemical markers, and clinical tissue tests in an effort to help osteopathic physicians to understand, diagnose, and manage the pathophysiology behind mTBI, which is increasingly prevalent in the United States...
August 12, 2020: Journal of the American Osteopathic Association
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