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Nanotech and genetics of addictive disease and withdrawal

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3 papers 100 to 500 followers Amazing landmark research affecting clinical practice
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
Inge Mick, Jim Myers, Anna C Ramos, Paul R A Stokes, David Erritzoe, Alessandro Colasanti, Roger N Gunn, Eugenii A Rabiner, Graham E Searle, Adam D Waldman, Mark C Parkin, Alan D Brailsford, José C F Galduróz, Henrietta Bowden-Jones, Luke Clark, David J Nutt, Anne R Lingford-Hughes
Pathological gambling is a psychiatric disorder and the first recognized behavioral addiction, with similarities to substance use disorders but without the confounding effects of drug-related brain changes. Pathophysiology within the opioid receptor system is increasingly recognized in substance dependence, with higher mu-opioid receptor (MOR) availability reported in alcohol, cocaine and opiate addiction. Impulsivity, a risk factor across the addictions, has also been found to be associated with higher MOR availability...
June 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Kenneth Blum, Thomas J H Chen, B William Downs, Abdalla Bowirrat, Roger L Waite, Eric R Braverman, Margaret Madigan, Marlene Oscar-Berman, Nicholas DiNubile, Eric Stice, John Giordano, Siobhan Morse, Mark Gold
BACKGROUND AND HYPOTHESIS: It is well known that after prolonged abstinence, individuals who use their drug of choice experience a powerful euphoria that often precipitates relapse. While a biological explanation for this conundrum has remained elusive, we hypothesize that this clinically observed "supersensitivity" might be tied to genetic dopaminergic polymorphisms. Another therapeutic conundrum relates to the paradoxical finding that the dopaminergic agonist bromocriptine induces stronger activation of brain reward circuitry in individuals who carry the DRD2 A1 allele compared with DRD2 A2 allele carriers...
November 2009: Postgraduate Medicine
T A Ignatowski, R Aalinkeel, J L Reynolds, B B Nair, D E Sykes, C P K Gleason, W C Law, M J Mammen, P N Prasad, S A Schwartz, Supriya D Mahajan
Opiates act on the dopaminergic system of the brain and perturb 32 kDa dopamine and adenosine 3', 5'-monophosphate-regulated phosphoprotein (DARPP-32) function. The DARPP-32 mediated inhibition of protein phosphatase-1 (PP-1) and modulation of transcriptional factor CREB is critical to the changes in neuronal plasticity that result in behavioral responses during drug abuse. To investigate the role of DARPP-32 mediated signaling on withdrawal behavior in a rat model of opiate addiction, we used intracerebral administration of gold nanorods (GNR) complexed to DARPP-32 siRNA to silence DARPP-32 gene expression and measure its effects on the opiate withdrawal syndrome...
March 2015: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
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