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Endothelial Function and Disease

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160 papers 25 to 100 followers
By Gregory Gustafson Interventional Cardiologist
Albino Carrizzo, Claudio Procaccini, Paola Lenzi, Clorinda Fusco, Francesco Villa, Serena Migliarino, Massimiliano De Lucia, Francesco Fornai, Giuseppe Matarese, Annibale A Puca, Carmine Vecchione
Background: Pentraxin 3 (PTX3), an acute-phase inflammation protein produced by several cell types, has long been described as a possible biomarker for age-related cardiovascular and cerebrovascular diseases. Although several mechanisms of action have been identified to date in the vascular and immune systems, the direct effects of PTX3 on isolated endothelial cells at morphological and metabolic levels remain unknown. Findings: PTX3 induced cytoplasmic vacuolization and dilution of mitochondrial matrix in isolated, human endothelial cells...
2019: Immunity & Ageing: I & A
Hou-Qin Yuan, Ya-Meng Hao, Zhong Ren, Hong-Feng Gu, Feng-Tao Liu, Bin-Jie Yan, Shun-Lin Qu, Zhi-Han Tang, Lu-Shan Liu, Da-Xing Chen, Zhi-Sheng Jiang
Tissue factor pathway inhibitor (TFPI) reduces the development of atherosclerosis by regulating tissue factor (TF) mediated coagulation pathway. In this review, we focus on recent findings on the inhibitory effects of TFPI on endothelial cell activation, vascular smooth muscle cell (VSMC) proliferation and migration, inflammatory cell recruitment and extracellular matrix which are associated with the development of atherosclerosis. Meanwhile, we are also concerned about the impact of TFPI levels and genetic polymorphisms on clinical atherogenesis...
January 26, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Giuliano Generoso, Carolina C P S Janovsky, Marcio S Bittencourt
PURPOSE OF REVIEW: In this review, we intend to show the heterogenicity of the triglyceride group, including the triglyceride-rich lipoproteins and its subparticles, apolipoproteins, and its role in atherogenesis through epidemiological and genetic studies, observing the association of these various components and subclasses with subclinical atherosclerosis and cardiovascular events. Also, we reevaluated the moment of blood collection for the triglyceride measurement and its repercussion in atherosclerosis...
January 28, 2019: Current Opinion in Endocrinology, Diabetes, and Obesity
Rudolf Poledne, Ivana Králová Lesná
Although current treatment of hypertension and hypercholesterolemia is most effective, cardiovascular mortality still remains at 50 % in industrialized countries. This could be explained by the rather high contribution of the inflammatory process to atherogenesis development. Use of high-sensitivity C-reactive protein (hsCRP) determination in several large epidemiological studies has made it possible to document increased risk of myocardial infarction in individuals with slightly increased hsCRP concentrations, which could thus serve as a discriminatory factor in cardiovascular disease risk assessment...
2019: Vnitr̆ní Lékar̆ství
Navkaranbir S Bajaj, Michael T Osborne, Ankur Gupta, Ali Tavakkoli, Paco E Bravo, Tomas Vita, Courtney F Bibbo, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Deepak L Bhatt, Marcelo F Di Carli, Viviany R Taqueti
BACKGROUND: Besides body mass index (BMI), other discriminators of cardiovascular risk are needed in obese patients, who may or may not undergo consideration for bariatric surgery. Coronary microvascular dysfunction (CMD), defined as impaired coronary flow reserve (CFR) in the absence of flow-limiting coronary artery disease, identifies patients at risk for adverse events independently of traditional risk factors. OBJECTIVES: The study sought to investigate the relationship among obesity, CMD, and adverse outcomes...
August 14, 2018: Journal of the American College of Cardiology
Katharina Kessler, Silke Hornemann, Klaus J Petzke, Margrit Kemper, Mariya Markova, Natalia Rudovich, Tilman Grune, Achim Kramer, Andreas F H Pfeiffer, Olga Pivovarova-Ramich
Background: A diet in which fat is mainly eaten in the morning and carbohydrates mainly in the evening (compared with the reverse order) was recently shown to worsen glycemic control in people with prediabetes. Objective: We investigated the effects of these dietary patterns on energy metabolism, and on the daily profiles of circulating lipids, adipokines, and inflammatory markers. Design: In a randomized controlled crossover trial, 29 nonobese men (with normal glucose tolerance, n = 18; or impaired fasting glucose/glucose tolerance, n = 11) underwent 2 isocaloric 4-wk diets: 1) carbohydrate-rich meals until 1330 and fat-rich meals between 1630 and 2200 (HC/HF); or 2) the inverse sequence of meals (HF/HC)...
December 1, 2018: American Journal of Clinical Nutrition
Paul M Ridker
Life-threatening cardiovascular events occur despite control of conventional risk factors. Inflammation, as measured by high-sensitivity C-reactive protein (hsCRP) concentration, is associated with future vascular events in both primary and secondary prevention, independent of usual risk markers. Statins are powerful lipid-lowering agents with clinically relevant anti-inflammatory effects. Recent data support targeting the interleukin (IL)-1-to-IL-6-to-CRP signaling pathway as an adjunctive method for atheroprotection...
December 25, 2018: Journal of the American College of Cardiology
Thomas F Lüscher
No abstract text is available yet for this article.
October 7, 2018: European Heart Journal
Robert W Regenhardt, Alvin S Das, Eng H Lo, Louis R Caplan
Importance: Stroke is the second leading cause of death in the world, and nearly one-third of ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in size, they create large problems, leaving many patients with intellectual and physical disabilities. Because there are limitations in understanding the underlying pathophysiology of LS, the development of novel therapies has been slow. Observations: When the term lacune was described in the 1800s, its underlying pathophysiological basis was obscure...
October 1, 2018: JAMA Neurology
Wai Chung Yong, Anawin Sanguankeo, Sikarin Upala
In rheumatoid arthritis and systemic lupus erythematosus, cardiovascular disease is frequently one of the leading causes of mortality or morbidity. Studies have shown that acute systemic inflammation and chronic systemic vasculitis are associated with endothelial dysfunction and atherosclerotic plaque formation, subsequently leading to cardiovascular disease. This meta-analysis aimed to explore the association of subclinical atherosclerosis and arterial stiffness in primary Sjogren's syndrome. A comprehensive search of the MEDLINE and Embase databases was performed from date of inception through August 2017...
September 3, 2018: Clinical Rheumatology
Simon Trommer, Anja Leimert, Michael Bucher, Julia Schumann
In sepsis, endothelial dysfunction is a crucial driver known to limit the survival rate of affected patients. For this, ROS-mediated signaling plays an important role in endothelial communication and functionality. In the management of sepsis, polyunsaturated fatty acids (PUFA) have received increasing attention regarding their anti-inflammatory potential neglecting the oxidative properties of these substances. Therefore, in the present study we examined the capacity of PUFA to interfere with the expression of major ROS-producing enzymes, as well as endothelial ROS production itself...
2018: Advances in Experimental Medicine and Biology
Elizabeth K Potter, Luke Hodgson, Ben Creagh-Brown, Lui G Forni
BACKGROUND: Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. Disturbed microvascular blood flow is associated with excess mortality and is a potential future target for interventions. This review addresses the evidence for pharmacological manipulation of the microcirculation in sepsis assessed by techniques that evaluate the sublingual microvasculature. METHODS: Systematic review using a published protocol. Eligibility criteria were studies of septic patients published from Jan 2000 - February 2018...
August 10, 2018: Shock
Giuseppe Ciliberti, Stefano Coiro, Isabella Tritto, Martina Benedetti, Federico Guerra, Maurizio Del Pinto, Gherardo Finocchiaro, Claudio Cavallini, Alessandro Capucci, Juan Carlos Kaski, Giuseppe Ambrosio
OBJECTIVE: To assess the characteristics and prognosis of patients with myocardial infarction and non-obstructed coronary arteries (MINOCA). METHODS: MINOCA was defined as acute myocardial infarction (AMI) with angiographic coronary stenosis <50%.Cardiomyopathies and myocarditis were - a priori - excluded from the study. Stenoses <30% were considered normal coronary arteries (NCA); stenoses ≥30% but <50% were considered mild coronary artery disease (MCAD)...
September 15, 2018: International Journal of Cardiology
Jordan Kho, Xiaoyu Tian, Wing-Tak Wong, Terry Bertin, Ming-Ming Jiang, Shan Chen, Zixue Jin, Oleg A Shchelochkov, Lindsay C Burrage, Anilkumar K Reddy, Hong Jiang, Reem Abo-Zahrah, Shuangtao Ma, Ping Zhang, Karl-Dimiter Bissig, Jean J Kim, Sridevi Devaraj, George G Rodney, Ayelet Erez, Nathan S Bryan, Sandesh C S Nagamani, Brendan H Lee
Primary hypertension is a major risk factor for ischemic heart disease, stroke, and chronic kidney disease. Insights obtained from the study of rare Mendelian forms of hypertension have been invaluable in elucidating the mechanisms causing primary hypertension and development of antihypertensive therapies. Endothelial cells play a key role in the regulation of blood pressure; however, a Mendelian form of hypertension that is primarily due to endothelial dysfunction has not yet been described. Here, we show that the urea cycle disorder, argininosuccinate lyase deficiency (ASLD), can manifest as a Mendelian form of endothelial-dependent hypertension...
August 2, 2018: American Journal of Human Genetics
Maciej Banach, Angelo Maria Patti, Rosaria Vincenza Giglio, Arrigo F G Cicero, Atanas G Atanasov, Gani Bajraktari, Eric Bruckert, Olivier Descamps, Dragan M Djuric, Marat Ezhov, Zlatko Fras, Stephan von Haehling, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, G B John Mancini, Dimitri P Mikhailidis, Olena Mitchenko, Patrick M Moriarty, Paul Muntner, Dragana Nikolic, Demosthenes B Panagiotakos, Gyorgy Paragh, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Giuseppe M C Rosano, Robert S Rosenson, Jacek Rysz, Amirhossein Sahebkar, Maria-Corina Serban, Dragos Vinereanu, Michal Vrablík, Gerald F Watts, Nathan D Wong, Manfredi Rizzo
Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment...
July 3, 2018: Journal of the American College of Cardiology
Ulf Landmesser, Stan Hazen
No abstract text is available yet for this article.
June 14, 2018: European Heart Journal
Andros Tofield
No abstract text is available yet for this article.
June 7, 2018: European Heart Journal
Lingyu Zhang, Tiantian Zhang, Lin Ding, Jie Xu, Changhu Xue, Teruyoshi Yanagita, Yaoguang Chang, Yuming Wang
SCOPE: Cerebroside is an active component extracted from sea cucumber (SCC), which is a traditional tonic food in China. In this study, the protective effect of SCC on atherogenesis is investigated and the possible underlying mechanism is determined. METHOD AND RESULTS: Male C57BL/6J obese mice were first used to explore the impact of SCC at different doses on alleviating lipid disorders and insulin sensitivity. Then ApoE-/- mice were used to evaluate the protective activities of SCC on atherosclerosis...
August 2018: Molecular Nutrition & Food Research
Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Sachiko Nishimoto, Kimie Tanaka, Yasutomi Higashikuni, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Masataka Sata
BACKGROUND AND AIMS: Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein E-deficient (apoe-/- ) mice. METHODS: Eight-week-old male apoe-/- mice were fed a western-type diet (WTD) supplemented with 0...
August 2018: Atherosclerosis
Jennifer Mancio, Evangelos K Oikonomou, Charalambos Antoniades
Adipose tissue (AT) is no longer viewed as a passive, energy-storing depot, and a growing body of evidence supports the concept that both quantitative and qualitative aspects of AT are critical in determining an individual's cardiometabolic risk profile. Among all AT sites, perivascular AT (PVAT) has emerged as a depot with a distinctive biological significance in cardiovascular disease given its close anatomical proximity to the vasculature. Recent studies have suggested the presence of complex, bidirectional paracrine and vasocrine signalling pathways between the vascular wall and its PVAT, with far-reaching implications in cardiovascular diagnostics and therapeutics...
October 2018: Heart: Official Journal of the British Cardiac Society
2018-06-04 00:48:49
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