Vivek T Natarajan, Archana Singh, Avinash A Kumar, Pankaj Sharma, Hemanta K Kar, Laurent Marrot, Jean-Roch Meunier, Krishnamurthy Natarajan, Rajni Rani, Rajesh S Gokhale
Oxidative stress is widely believed to be a contributing factor in vitiligo pathogenesis. To explore mechanisms by which epidermis responds to mounting oxidative stress, we investigated the involvement of phase II detoxification genes in vitiligo. Phase II detoxification pathways have recently been identified as being important in the regulation of epidermal skin homeostasis. In this study we show that the key transcription factor nuclear factor E2-related factor 2 (Nrf2) and the downstream genes NAD(P)H:quinone oxidase-1 (NQO-1), γ-glutamyl cystine ligase catalytic subunit (GCLC), and γ-glutamyl cystine ligase modifying subunit (GCLM) are upregulated in the lesional epidermal skin of subjects with vitiligo vulgaris...
December 2010: Journal of Investigative Dermatology