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The Vitiligo Study

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24 papers 0 to 25 followers
By Kyla L Yett Nutritional Study | Vitiligo Study
P Amerio, M Tracanna, P De Remigis, C Betterle, L Vianale, M E Marra, D Di Rollo, R Capizzi, C Feliciani, A Tulli
Vitiligo is a common skin disease characterized by depigmented maculae resulting from a reduction of the number and function of melanocytes. Many studies suggest that vitiligo might be an autoimmune disease. Vitiligo has been frequently described in association with other autoimmune diseases. Among the diseases described in association with vitiligo are the so-called autoimmune polyglandular syndromes (APS). Vitiligo can be present in all types of APS but the most frequent association appears to be in APS-3...
September 2006: Clinical and Experimental Dermatology
Anitha Nagarajan, Mahaboob Kader Masthan, Leena Sankari Sankar, Aravindha Babu Narayanasamy, Rajesh Elumalai
BACKGROUND: Vitiligo is one of the disorder that has social impact. Both skin and mucous membrane show depigmentation in vitiligo. Depigmentation in oral cavity can be more easily observed and the patient can be given awareness regarding the condition if they are unaware of vitiligo elsewhere in their body and can be guided for treatment. AIM AND OBJECTIVES: The aim of this study is to determine the frequency of occurrence of oral mucosal vitiligo in vitiligo patients and to determine the most commonly involved oral mucosal site...
January 2015: Indian Journal of Dermatology
Ying Jin, Christina M Mailloux, Katherine Gowan, Sheri L Riccardi, Greggory LaBerge, Dorothy C Bennett, Pamela R Fain, Richard A Spritz
BACKGROUND: Autoimmune and autoinflammatory diseases involve interactions between genetic risk factors and environmental triggers. We searched for a gene on chromosome 17p13 that contributes to a group of epidemiologically associated autoimmune and autoinflammatory diseases. The group includes various combinations of generalized vitiligo, autoimmune thyroid disease, latent autoimmune diabetes in adults, rheumatoid arthritis, psoriasis, pernicious anemia, systemic lupus erythematosus, and Addison's disease...
March 22, 2007: New England Journal of Medicine
Ali Alikhan, Lesley M Felsten, Meaghan Daly, Vesna Petronic-Rosic
Vitiligo is an acquired pigmentary disorder of unknown etiology that is clinically characterized by the development of white macules related to the selective loss of melanocytes. The prevalence of the disease is around 1% in the United States and in Europe, but ranges from less than 0.1% to greater than 8% worldwide. A recorded predominance of women may reflect their greater willingness to express concern about cosmetically relevant issues. Half of all patients develop the disease before 20 years of age. Onset at an advanced age occurs but is unusual, and should raise concerns about associated diseases, such as thyroid dysfunction, rheumatoid arthritis, diabetes mellitus, and alopecia areata...
September 2011: Journal of the American Academy of Dermatology
Vaneeta M Sheth, Ye Guo, Abrar A Qureshi
BACKGROUND: Vitiligo is a common disorder of depigmentation that has been associated with other autoimmune diseases. No recent large-scale data exist on the rates of comorbidities associated with vitiligo from the United States population. OBJECTIVES: To identify the prevalence of comorbidities as well as associated laboratory abnormalities in vitiligo patients. METHODS: All medical records dating from January 1, 2000 to June 21, 2011 within the Research Patient Data Repository were evaluated retrospectively using a novel artificial intelligence-based computer program...
2013: Dermatology: International Journal for Clinical and Investigative Dermatology
Shahla Babaee Nejad, Hamideh Herizchi Qadim, Leila Nazeman, Roohollah Fadaii, Mohamad Goldust
Vitiligo is more common in people with certain autoimmune diseases. Here we studied the association between vitiligo and autoimmune diseases. In this case control study, 86 patients with vitiligo were questioned about the location of vitiligo, family history, treatment and therapeutic response. All patients were examined both clinically and with laboratory tests to detect the presence of autoimmune disorders including autoimmune thyroid disease, pernicious anemia, insulin dependent diabetes, and Systemic Lupus Erythematic (SLE) and Addison disease...
June 15, 2013: Pakistan Journal of Biological Sciences: PJBS
Jacek Kasznicki, Józef Drzewoski
We present a case of autoimmune polyglandular syndrome type III (APS III) associated with Hashimoto's disease, type 1 diabetes mellitus, vitiligo and autoimmune urticaria. This rare genetic disorder occurs with unknown frequency in the Polish population. It is characterised by endocrine tissue destruction resulting in the malfunction of multiple organs.Several cases of APS III associated with organ-specific autoimmune diseases such as coeliac disease, hypogonadism and myasthenia gravis, as well as organ-nonspecific or systemic autoimmune diseases such as sarcoidosis, Sjögren syndrome, and rheumatoid arthritis have been described...
2014: Endokrynologia Polska
Karin U Schallreuter, Mohammed A E L Salem, Sarah Holtz, A Panske
Nonsegmental vitiligo (NSV) is characterized by loss of inherited skin color. The cause of the disease is still unknown despite accumulating in vivo and in vitro evidence of massive epidermal oxidative stress via H2O2 and peroxynitrite (ONOO(-)) in affected individuals. The most favored hypothesis is based on autoimmune mechanisms. Strictly segmental vitiligo (SSV) with dermatomal distribution is a rare entity, often associated with stable outcome. Recently, it was documented that this form can be associated with NSV (mixed vitiligo)...
August 2013: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Jillian M Richmond, Michael L Frisoli, John E Harris
Vitiligo is an autoimmune disease of the skin in which melanocytes are destroyed by antigen-specific T cells, resulting in patchy depigmentation. Although adaptive immunity plays a clear role in disease progression, initiating factors are largely unknown. Many studies report that cellular stress pathways are dysregulated in melanocytes from vitiligo patients, suggesting that melanocyte-intrinsic defects participate in disease pathogenesis. Recent studies reveal that melanocyte stress generates damage-associated molecular patterns that activate innate immunity, thus connecting stress to organ-specific inflammation...
December 2013: Current Opinion in Immunology
Hansje-Eva Teulings, Jacqueline Limpens, Sophia N Jansen, Aeilko H Zwinderman, Johannes B Reitsma, Phyllis I Spuls, Rosalie M Luiten
PURPOSE: Vitiligo-like depigmentation in patients with melanoma may be associated with more favorable clinical outcome. We conducted a systematic review of patients with stage III to IV melanoma treated with immunotherapy to determine the cumulative incidence of vitiligo-like depigmentation and the prognostic value of vitiligo development on survival. METHODS: We systemically searched and selected all studies on melanoma immunotherapy that reported on autoimmune toxicity and/or vitiligo between 1995 and 2013...
March 1, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Amir Feily
Although skin is the largest organ of the body, there are no standardized reproducible methods for assessing severity of many skin diseases. Due to lack of consensus, methods of assessment and inexistence of precise scoring system, there is no application for vitiligo estimation in real practice. In this paper the author describes VETI score as a new treatment evaluation criteria and severity assessment method for vitiligo. This new tool, as does the PASI score in psoriasis, may be able to produce a constant and reproducible number and to help clinical research on vitiligo patients...
October 2014: Dermatology Practical & Conceptual
F A Le Gal, M F Avril, J Bosq, P Lefebvre, J C Deschemin, M Andrieu, M X Dore, J G Guillet
Vitiligo is a cutaneous pigmentary disorder characterized by the loss of melanocytes. An autoimmune mechanism is strongly suspected to be involved in this affection given that it is frequently associated with autoimmune hormonal disorders, and because antibodies directed against melanocytic antigens are found in the serum of patients with vitiligo. We examined the role of cellular immunity in melanoma-associated vitiligo by expanding infiltrating lymphocytes from fresh biopsy specimens of vitiligo patches in melanoma patients...
December 2001: Journal of Investigative Dermatology
Sylvia Adams, Michelle A Lowes, David W O'Neill, Stephen Schachterle, Pedro Romero, Nina Bhardwaj
Vitiligo, a skin disorder characterized by the spontaneous destruction of melanocytes, is believed to be of autoimmune origin. We investigated the presence and functionality of CD8(+) T-cells specific for the melanocyte-associated antigens Melan-A, gp100, tyrosinase, and TRP-2 in the blood of HLA-A2(+) vitiligo patients. We enumerated antigen-specific CD8(+) T cells by major histocompatibility complex multimer staining directly ex vivo, as well as after 9 days of in vitro stimulation and assessed IFN-gamma secretion by enzyme-linked immunospot (Elispot) assay...
August 2008: Journal of Investigative Dermatology
M K Tembhre, A S Parihar, V K Sharma, A Sharma, P Chattopadhyay, S Gupta
BACKGROUND: Vitiligo is an autoimmune depigmentation disease, and defects in regulatory T cells (Tregs) have been proposed in the pathogenesis of generalized vitiligo (GV). However, the role of programmed cell death (PD)1(+) Tregs has not been studied. OBJECTIVES: To investigate the status of Tregs, PD1(+) Tregs and associated parameters in active GV (aGV) during the first episode of disease attack and to establish the clinical correlation. METHODS: The percentages of circulating Tregs, PD1(+) Tregs and CD3(+) CD4(+) PD1(+) T cells were evaluated in 50 patients with aGV and 51 controls...
April 2015: British Journal of Dermatology
D J Gawkrodger, A D Ormerod, L Shaw, I Mauri-Sole, M E Whitton, M J Watts, A V Anstey, J Ingham, K Young
This detailed and user-friendly guideline for the diagnosis and management of vitiligo in children and adults aims to give high quality clinical advice, based on the best available evidence and expert consensus, taking into account patient choice and clinical expertise. The guideline was devised by a structured process and is intended for use by dermatologists and as a resource for interested parties including patients. Recommendations and levels of evidence have been graded according to the method developed by the Scottish Inter-Collegiate Guidelines Network...
November 2008: British Journal of Dermatology
A Taieb, A Alomar, M Böhm, M L Dell'anna, A De Pase, V Eleftheriadou, K Ezzedine, Y Gauthier, D J Gawkrodger, T Jouary, G Leone, S Moretti, L Nieuweboer-Krobotova, M J Olsson, D Parsad, T Passeron, A Tanew, W van der Veen, N van Geel, M Whitton, A Wolkerstorfer, M Picardo
The aetiopathogenic mechanisms of vitiligo are still poorly understood, and this has held back progress in diagnosis and treatment. Up until now, treatment guidelines have existed at national levels, but no common European viewpoint has emerged. This guideline for the treatment of segmental and nonsegmental vitiligo has been developed by the members of the Vitiligo European Task Force and other colleagues. It summarizes evidence-based and expert-based recommendations (S1 level).
January 2013: British Journal of Dermatology
Shilpak Chatterjee, Jonathan M Eby, Amir A Al-Khami, Myroslawa Soloshchenko, Hee-Kap Kang, Navtej Kaur, Osama S Naga, Anuradha Murali, Michael I Nishimura, I Caroline Le Poole, Shikhar Mehrotra
T-cell cytolytic activity targeting epidermal melanocytes is shown to cause progressive depigmentation and autoimmune vitiligo. By using the recently developed transgenic mice h3TA2 that carry T cells with a HLA-A2-restricted human tyrosinase peptide (h-Tyr)-reactive TCR and develop spontaneous vitiligo from an early age, we addressed the mechanism regulating autoimmune vitiligo. Depigmentation was significantly impaired only in IFN-γ-knockout h3TA2 mice but not in TNF-α- or perforin-knockout h3TA2 mouse strains, confirming a central role for IFN-γ in vitiligo development...
May 2014: Journal of Investigative Dermatology
V Eleftheriadou, M E Whitton, D J Gawkrodger, J Batchelor, J Corne, B Lamb, S Ersser, J Ravenscroft, K S Thomas
BACKGROUND: Vitiligo is the most frequent depigmentation disorder of the skin and is cosmetically and psychologically devastating. A recently updated Cochrane systematic review 'Interventions for vitiligo' showed that the research evidence for treatment of vitiligo is poor, making it difficult to make firm recommendations for clinical practice. OBJECTIVES: To stimulate and steer future research in the field of vitiligo treatment, by identifying the 10 most important research areas for patients and clinicians...
March 2011: British Journal of Dermatology
Ying Jin, Stanca A Birlea, Pamela R Fain, Tracey M Ferrara, Songtao Ben, Sheri L Riccardi, Joanne B Cole, Katherine Gowan, Paulene J Holland, Dorothy C Bennett, Rosalie M Luiten, Albert Wolkerstorfer, J P Wietze van der Veen, Anke Hartmann, Saskia Eichner, Gerold Schuler, Nanja van Geel, Jo Lambert, E Helen Kemp, David J Gawkrodger, Anthony P Weetman, Alain Taïeb, Thomas Jouary, Khaled Ezzedine, Margaret R Wallace, Wayne T McCormack, Mauro Picardo, Giovanni Leone, Andreas Overbeck, Nanette B Silverberg, Richard A Spritz
We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals with vitiligo (cases) and 3,182 controls), an independent replication study (1,440 cases and 1,316 controls) and a meta-analysis (3,187 cases and 6,723 controls) identifying 13 additional vitiligo-associated loci. These include OCA2-HERC2 (combined P = 3.80 × 10(-8)), MC1R (P = 1.82 × 10(-13)), a region near TYR (P = 1.57 × 10(-13)), IFIH1 (P = 4...
May 6, 2012: Nature Genetics
K Ezzedine, H W Lim, T Suzuki, I Katayama, I Hamzavi, C C E Lan, B K Goh, T Anbar, C Silva de Castro, A Y Lee, D Parsad, N van Geel, I C Le Poole, N Oiso, L Benzekri, R Spritz, Y Gauthier, S K Hann, M Picardo, A Taieb
During the 2011 International Pigment Cell Conference (IPCC), the Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel of experts, the conference focused on four topics: classification and nomenclature; definition of stable disease; definition of Koebner's phenomenon (KP); and 'autoimmune vitiligo'. These topics were discussed in seven working groups representing different geographical regions...
May 2012: Pigment Cell & Melanoma Research
2015-01-21 00:47:44
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