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By Hermenio Lima McMaster university
Grace L Lee, Matthew J Zirwas
Granulomatous rosacea and periorificial dermatitis are common skin conditions affecting the face. This article examines the historical origin, causes, clinical presentation, and management strategies for these entities.
July 2015: Dermatologic Clinics
Roni P Dodiuk-Gad, Neil H Shear
Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a granulomatous reaction pattern are rare, and defined by a predominance of histiocytes in the inflammatory infiltrate. This review summarizes current knowledge on the various types of granulomatous drug eruptions, focusing on the 4 major types: interstitial granulomatous drug reaction, drug-induced accelerated rheumatoid nodulosis, drug-induced granuloma annulare, and drug-induced sarcoidosis...
July 2015: Dermatologic Clinics
Eliezer M Van Allen, Diana Miao, Bastian Schilling, Sachet A Shukla, Christian Blank, Lisa Zimmer, Antje Sucker, Uwe Hillen, Marnix H Geukes Foppen, Simone M Goldinger, Jochen Utikal, Jessica C Hassel, Benjamin Weide, Katharina C Kaehler, Carmen Loquai, Peter Mohr, Ralf Gutzmer, Reinhard Dummer, Stacey Gabriel, Catherine J Wu, Dirk Schadendorf, Levi A Garraway
Monoclonal antibodies directed against cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for patients with metastatic melanoma by inhibiting immune checkpoint activity, but clinical predictors of response to these therapies remain incompletely characterized. To investigate the roles of tumor-specific neoantigens and alterations in the tumor microenvironment in the response to ipilimumab, we analyzed whole exomes from pretreatment melanoma tumor biopsies and matching germline tissue samples from 110 patients...
October 9, 2015: Science
Edward J van Opstal, Seth R Bordenstein
No abstract text is available yet for this article.
September 11, 2015: Science
Katherine J Ransohoff, Jean Y Tang, Kavita Y Sarin
No abstract text is available yet for this article.
September 10, 2015: New England Journal of Medicine
(no author information available yet)
New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print.
July 24, 2014: New England Journal of Medicine
Kenneth A Katz
No abstract text is available yet for this article.
February 2015: JAMA Dermatology
Razieh Soltani-Arabshahi, Carol Sweeney, Benjamin Jones, Scott R Florell, Nan Hu, Douglas Grossman
OBJECTIVE: Clinical detection of melanoma can be challenging. The number of biopsy specimens performed to diagnose 1 melanoma is a measure of efficiency of skin cancer detection, but few data are available to describe this measure from US health care. We studied the diagnosis of melanoma among biopsy specimens of clinically concerning pigmented lesions at an academic dermatology department. METHODS: We searched for all biopsy specimens that were performed because of clinical suspicion of melanoma in 2013...
March 2015: Journal of the American Academy of Dermatology
Maria Celia B Hughes, Gail M Williams, Peter Baker, Adèle C Green
BACKGROUND: Sunscreen use and dietary antioxidants are advocated as preventives of skin aging, but supporting evidence is lacking. OBJECTIVE: To determine whether regular use of sunscreen compared with discretionary use or β-carotene supplements compared with placebo retard skin aging, measured by degree of photoaging. DESIGN: Randomized, controlled, community-based intervention. (Australian New Zealand Clinical Trials Registry: ACTRN12610000086066)...
June 4, 2013: Annals of Internal Medicine
Marcus Maurer, Karin Rosén, Hsin-Ju Hsieh, Sarbjit Saini, Clive Grattan, Ana Gimenéz-Arnau, Sunil Agarwal, Ramona Doyle, Janice Canvin, Allen Kaplan, Thomas Casale
BACKGROUND: Many patients with chronic idiopathic urticaria (also called chronic spontaneous urticaria) do not have a response to therapy with H-antihistamines, even at high doses. In phase 2 trials, omalizumab, an anti-IgE monoclonal antibody [corrected] that targets IgE and affects mast-cell and basophil function, has shown efficacy in such patients. METHODS: In this phase 3, multicenter, randomized, double-blind study, we evaluated the efficacy and safety of omalizumab in patients with moderate-to-severe chronic idiopathic urticaria who remained symptomatic despite H-antihistamine therapy (licensed doses)...
March 7, 2013: New England Journal of Medicine
Howa Yeung, Joy Wan, Abby S Van Voorhees, Kristina Callis Duffin, Gerald G Krueger, Robert E Kalb, Jamie D Weisman, Brian R Sperber, Bruce A Brod, Stephen M Schleicher, Bruce F Bebo, Daniel B Shin, Andrea B Troxel, Joel M Gelfand
BACKGROUND: Despite widespread dissatisfaction and low treatment persistence in moderate to severe psoriasis, patients' reasons behind treatment discontinuation remain poorly understood. OBJECTIVES: We sought to characterize patient-reported reasons for discontinuing commonly used treatments for moderate to severe psoriasis in real-world clinical practice. METHODS: A total of 1095 patients with moderate to severe plaque psoriasis from 10 dermatology practices who received systemic treatments completed a structured interview...
January 2013: Journal of the American Academy of Dermatology
R Vasquez, D Wang, Q P Tran, B Adams-Huet, M-M Chren, M I Costner, J B Cohen, V P Werth, B F Chong
BACKGROUND:  A study at the University of Pennsylvania (UPenn) Medical Center demonstrated that quality of life in patients with cutaneous lupus erythematosus (CLE) is negatively impacted. Whether patients with CLE in other geographic locations have similar quality of life is unknown. OBJECTIVES:  We sought to compare quality of life indicators between patients with CLE at the University of Texas Southwestern (UTSW) Medical Center at Dallas and those at UPenn...
January 2013: British Journal of Dermatology
Yi-Ju Chen, Chun-Ying Wu, Jui-Lung Shen, Tzu-Ting Chen, Yun-Ting Chang
OBJECTIVE: To investigate the relative risk of cancer among patients with chronic urticaria in the Taiwanese population. DESIGN: Retrospective population-based cohort study. SETTING: The National Health Insurance Research Database of Taiwan from January 1, 1996, through December 31, 2008. PARTICIPANTS: A total of 12,720 patients with chronic urticaria, with long-term antihistamine use and no history of malignant tumors, autoimmune diseases, atopy, or allergic diseases...
January 2012: Archives of Dermatology
Daniel J Cua, Jonathan Sherlock, Yi Chen, Craig A Murphy, Barbara Joyce, Brian Seymour, Linda Lucian, Wayne To, Sylvia Kwan, Tatyana Churakova, Sandra Zurawski, Maria Wiekowski, Sergio A Lira, Daniel Gorman, Robert A Kastelein, Jonathon D Sedgwick
Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40 subunits. Analyses in vitro have defined IL-12 as an important factor for the differentiation of naive T cells into T-helper type 1 CD4+ lymphocytes secreting interferon-gamma (refs 1, 2). Similarly, numerous studies have concluded that IL-12 is essential for T-cell-dependent immune and inflammatory responses in vivo, primarily through the use of IL-12 p40 gene-targeted mice and neutralizing antibodies against p40. The cytokine IL-23, which comprises the p40 subunit of IL-12 but a different p19 subunit, is produced predominantly by macrophages and dendritic cells, and shows activity on memory T cells...
February 13, 2003: Nature
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