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By Whitney Buckel Infectious Diseases Pharmacist
Shay Weiss, Zeev Altboum, Itai Glinert, Josef Schlomovitz, Assa Sittner, Elad Bar-David, David Kobiler, Haim Levy
Respiratory anthrax is a fatal disease in the absence of early treatment with antibiotics. Rabbits are highly susceptible to infection with Bacillus anthracis spores by intranasal instillation, succumbing within 2 to 4 days postinfection. This study aims to test the efficiency of antibiotic therapy to treat systemic anthrax in this relevant animal model. Delaying the initiation of antibiotic administration to more than 24 h postinfection resulted in animals with systemic anthrax in various degrees of bacteremia and toxemia...
December 2015: Antimicrobial Agents and Chemotherapy
Janet K Dykes, Carolina Lúquez, Brian H Raphael, Loretta McCroskey, Susan E Maslanka
We report here the laboratory investigation of the first known case of botulism in the United States caused by Clostridium butyricum type E. This investigation demonstrates the importance of extensive microbiological examination of specimens, which resulted in the isolation of this organism.
October 2015: Journal of Clinical Microbiology
Chadi A Hage, Marwan M Azar, Nathan Bahr, James Loyd, L Joseph Wheat
Histoplasmosis is the most common endemic mycosis in the North America, Central America, and many countries of South America and also occurs in China, India, Southeast Asia, Africa, Australia, and Europe. Clinical syndromes are not specific and histoplasmosis often is overlooked in the evaluation of patients with community-acquired pneumonia, chronic cavitary pneumonia resembling tuberculosis or anaerobic infection, granulomatous inflammatory diseases such as sarcoidosis or Crohn disease, and malignancy. The diagnosis depends on understanding the geographic distribution, common clinical presentations, and tests used for diagnosis of histoplasmosis...
October 2015: Seminars in Respiratory and Critical Care Medicine
Azizul Haque, Didier Hober, Joel Blondiaux
Ebola virus can cause severe hemorrhagic disease with high fatality rates. Currently, no specific therapeutic agent or vaccine has been approved for treatment and prevention of Ebola virus infection of humans. Although the number of Ebola cases has fallen in the last few weeks, multiple outbreaks of Ebola virus infection and the likelihood of future exposure highlight the need for development and rapid evaluation of pre- and postexposure treatments. Here, we briefly review the existing and future options for anti-Ebola therapy, based on the data coming from rare clinical reports, studies on animals, and results from in vitro models...
October 2015: Antimicrobial Agents and Chemotherapy
Abdul Mannan Baig
No abstract text is available yet for this article.
December 2015: Antimicrobial Agents and Chemotherapy
Eddie Grace, Scott Asbill, Kris Virga
Naegleria fowleri has generated tremendous media attention over the last 5 years due to several high-profile cases. Several of these cases were followed very closely by the general public. N. fowleri is a eukaryotic, free-living amoeba belonging to the phylum Percolozoa. Naegleria amoebae are ubiquitous in the environment, being found in soil and bodies of freshwater, and feed on bacteria found in those locations. While N. fowleri infection appears to be quite rare compared to other diseases, the clinical manifestations of primary amoebic meningoencephalitis are devastating and nearly always fatal...
November 2015: Antimicrobial Agents and Chemotherapy
Deepti Damaraju, Ted Steiner, John Wade, Kenneth Gin, J Mark FitzGerald
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 63-year-old nonsmoking white man..
August 6, 2015: New England Journal of Medicine
Maria G Guzman, Eva Harris
Dengue viruses have spread rapidly within countries and across regions in the past few decades, resulting in an increased frequency of epidemics and severe dengue disease, hyperendemicity of multiple dengue virus serotypes in many tropical countries, and autochthonous transmission in Europe and the USA. Today, dengue is regarded as the most prevalent and rapidly spreading mosquito-borne viral disease of human beings. Importantly, the past decade has also seen an upsurge in research on dengue virology, pathogenesis, and immunology and in development of antivirals, vaccines, and new vector-control strategies that can positively impact dengue control and prevention...
January 31, 2015: Lancet
Colleen M Terriff, Mike D Schwartz, Ben M Lomaestro
OBJECTIVES: To discuss specific facts regarding use as a bioweapon, epidemiology, microbiology, clinical manifestations, diagnosis, antimicrobial therapy, immunization, and isolation precautions for five most likely agents of bioterrorism; to review and provide recommendations for health care clinicians on the management of these bioterrorism agents; and to share information on the pharmacist's role in preparedness and response. PARTICIPANTS: The manuscript was drafted by the three authors, reviewed by a group of selected members of the Society of Infectious Diseases Pharmacists, and approved by its Board of Directors...
March 2003: Pharmacotherapy
Seth E O'Neal, Robert H Flecker
Neurocysticercosis, brain infection with Taenia solium larval cysts, causes substantial neurologic illness around the world. To assess the effect of neurocysticercosis in the United States, we reviewed hospitalization discharge data in the Nationwide Inpatient Sample for 2003-2012 and found an estimated 18,584 hospitalizations for neurocysticercosis and associated hospital charges totaling >US $908 million. The risk for hospitalization was highest among Hispanics (2.5/100,000 population), a rate 35 times higher than that for the non-Hispanic white population...
June 2015: Emerging Infectious Diseases
Amesh A Adalja, Eric Toner, Thomas V Inglesby
The agents most likely to be used in bioterrorism attacks are reviewed, along with the clinical syndromes they produce and their treatment.
March 5, 2015: New England Journal of Medicine
Olga I Kosoy, Amy J Lambert, Dana J Hawkinson, Daniel M Pastula, Cynthia S Goldsmith, D Charles Hunt, J Erin Staples
A previously healthy man from eastern Kansas, USA, sought medical care in late spring because of a history of tick bite, fever, and fatigue. The patient had thrombocytopenia and leukopenia and was given doxycycline for a presumed tickborne illness. His condition did not improve. Multiorgan failure developed, and he died 11 days after illness onset from cardiopulmonary arrest. Molecular and serologic testing results for known tickborne pathogens were negative. However, testing of a specimen for antibodies against Heartland virus by using plaque reduction neutralization indicated the presence of another virus...
May 2015: Emerging Infectious Diseases
Manuelle Viguier, Matthieu Lafaurie
A 64-year-old man from Mauritania was referred for evaluation of a multinodular tumor of the left foot. Foot lesions had been present for 38 years, starting on the left heel and gradually spreading to involve the whole foot and ankle, with walking impairment. At the time that the patient was first..
January 15, 2015: New England Journal of Medicine
Mandakolathur R Murali, Jennifer W Uyeda, Bhatraphol Tingpej
Presentation of Case. Dr. Albert Yeh (Medicine): A 25-year-old man was admitted to this hospital because of abdominal pain, syncope, and hypotension. The patient had been well on the day of admission until, while lifting heavy boxes with a friend, he suddenly felt "a warm feeling" diffusely and had..
January 15, 2015: New England Journal of Medicine
William S David, Elizabeth S Temin, Jessica J Kraeft, David C Hooper
Presentation of Case. Dr. Kathy Chuang (Neurology): A 60-year-old woman was admitted to this hospital in midwinter because of abdominal pain, dyspnea, and diplopia. The patient had a history of asthma and gastroesophageal reflux disease. She had been well until the day before admission, when she..
January 22, 2015: New England Journal of Medicine
Natasha S Crowcroft, Nisha Thampi
No abstract text is available yet for this article.
January 14, 2015: BMJ: British Medical Journal
(no author information available yet)
No abstract text is available yet for this article.
December 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
(no author information available yet)
No abstract text is available yet for this article.
December 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Daniel S Chertow, Timothy M Uyeki, Herbert L DuPont
No abstract text is available yet for this article.
April 1, 2015: Journal of Infectious Diseases
Aristea Velegraki, Claudia Cafarchia, Georgios Gaitanis, Roberta Iatta, Teun Boekhout
No abstract text is available yet for this article.
January 2015: PLoS Pathogens
2015-01-15 18:07:43
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