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Type 2 Diabetes Mellitus

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341 papers 100 to 500 followers prediction, prevention, screening for hyperglycemia/T2DM; glucose control, outcomes, and complications of T2DM; interrelated issues of T2DM with CVD risk, obesity, metabolic syndrome
By Jamie Jarmul Md / PhD student at UNC - Chapel Hill, PhD in Health Policy and Management
Patricia Garnica
BACKGROUND: Diabetes is a common chronic condition among adults that can complicate the transition from the hospital to the community. Hospital readmission is an important contributor to total medical expenditures and is an emerging indicator of quality of care. Failure to acknowledge diabetes transition of care is associated with increased emergency department visits and 30-day readmissions. METHODS: Literature review of transition of care models, sample tools and processes are presented...
2017: Current Diabetes Reviews
Mohammed K Ali, Kavita Singh, Dimple Kondal, Raji Devarajan, Shivani A Patel, Roopa Shivashankar, Vamadevan S Ajay, A G Unnikrishnan, V Usha Menon, Premlata K Varthakavi, Vijay Viswanathan, Mala Dharmalingam, Ganapati Bantwal, Rakesh Kumar Sahay, Muhammad Qamar Masood, Rajesh Khadgawat, Ankush Desai, Bipin Sethi, Dorairaj Prabhakaran, K M Venkat Narayan, Nikhil Tandon
BACKGROUND: Achievement of diabetes care goals is suboptimal globally. Diabetes-focused quality improvement (QI) is effective but remains untested in South Asia. OBJECTIVE: To compare the effect of a multicomponent QI strategy versus usual care on cardiometabolic profiles in patients with poorly controlled diabetes. DESIGN: Parallel, open-label, pragmatic randomized, controlled trial. ( NCT01212328). SETTING: Diabetes clinics in India and Pakistan...
September 20, 2016: Annals of Internal Medicine
Antonino Tuttolomondo, Carlo Maida, Antonio Pinto
Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus associated with a high degree of morbidity and mortality; in fact, some authors showed a higher prevalence of major, previous and new-onset, cardiovascular, and cerebrovascular events in diabetic patients with foot ulcers than in those without these complications. This is consistent with the fact that in diabetes there is a complex interplay of several variables with inflammatory metabolic disorders and their effect on the cardiovascular system that could explain previous reports of high morbidity and mortality rates in diabetic patients with amputations...
2015: Journal of Diabetes Research
Usha Shrivastava, Anoop Misra
Noncommunicable diseases, including type 2 diabetes mellitus and cardiovascular diseases (CVDs), cause 7.9 million deaths every year in South Asia. India has nearly 65.1 million cases of diabetes, and Pakistan and Bangladesh are at the 12(th) and 13(th) positions in the global list of high prevalence countries, respectively. The prevalence in India is continuously increasing and is recently reported to be nearly 14% and 8% in urban areas and rural areas, respectively. Diabetes in South Asians is, in some manner, different from that in other races; it occurs nearly a decade earlier, at lower body mass index and waist circumference levels, and with more postprandial hyperglycemia, dyslipidemia, nephropathy, and CVD than in whites...
June 2015: Diabetes Technology & Therapeutics
Mitsuyoshi Takahara, Naoto Katakami, Takeshi Osonoi, Miyoko Saitou, Fumie Sakamoto, Taka-Aki Matsuoka, Iichiro Shimomura
AIM: We statistically investigated whether the impact of cardiovascular risk factors on arterial stiffness would be different from that on arterial wall thickness. METHODS: We analyzed 1648 Japanese type 2 diabetic patients. Arterial stiffness was evaluated by pulse wave verbosity (PWV) and wall thickness was assessed with carotid intima-media thickness (IMT) by ultrasonography. We developed a common regression model to PWV and IMT by extending the linear mixed model and statistically detected the difference in the impact of cardiovascular risk factors between the two indices...
2015: Journal of Atherosclerosis and Thrombosis
Francisco Arrieta, Pedro Iglesias, Juan Pedro-Botet, Francisco Javier Tébar, Emilio Ortega, Andreu Nubiola, Jose Luis Pardo, Gonzálo Fernando Maldonado, Juan Carlos Obaya, Pablo Matute, Romina Petrecca, Nuria Alonso, Elena Sarabia, Victor Sánchez-Margalet, José Juan Alemán, Jorge Navarro, Antonio Becerra, Santiago Duran, Manuel Aguilar, Fernando Escobar-Jiménez
The present paper updates the Clinical Practice Recommendations for the management of cardiovascular risk factors (CVRF) in diabetes mellitus. This is a medical consensus agreed by an independent panel of experts from the Spanish Society of Diabetes (SED). Several consensuses have been proposed by scientific and medical Societies to achieve clinical goals. However, the risk score for general population may lack sensitivity for individual assessment or for particular groups at risk, such as diabetics. Traditional risk factors together with non-traditional factors are reviewed throughout this paper...
July 2015: Clínica e Investigación en Arteriosclerosis
Esther Rubinat, Josep Ramon Marsal, Teresa Vidal, Cristina Cebrian, Mireia Falguera, Ma Belen Vilanova, Àngels Betriu, Elvira Fernández, Josep Franch, Dídac Mauricio
BACKGROUND: Subjects with type 2 diabetes mellitus are considered to be at high risk for cardiovascular disease. The identification of carotid atherosclerosis is a validated surrogate marker of cardiovascular disease. Nurses are key professionals in the improvement and intensification of cardiovascular preventive strategies. AIMS: The aim is to study the presence of carotid atherosclerosis in a group of asymptomatic subjects with type 2 diabetes mellitus and no previous clinical cardiovascular disease...
March 2016: Journal of Cardiovascular Nursing
Rosie Dobson, Karen Carter, Richard Cutfield, Ashley Hulme, Richard Hulme, Catherine McNamara, Ralph Maddison, Rinki Murphy, Matthew Shepherd, Johan Strydom, Robyn Whittaker
BACKGROUND: The increasing prevalence of diabetes and costly long-term complications associated with poor glycemic control are issues facing health services worldwide. Diabetes self-management, with the support of health care providers, is critical for successful outcomes, however, frequent clinical contact is costly. Text messages via short message service (SMS) have the advantage of instant transmission at low cost and, given the ubiquity of mobile phones, may be the ideal platform for the delivery of diabetes self-management support...
2015: JMIR MHealth and UHealth
Yue Zhong, Pei-Jung Lin, Joshua T Cohen, Aaron N Winn, Peter J Neumann
OBJECTIVES: To systematically review the cost-effectiveness of diabetes interventions, identify high-value diabetes services, and estimate potential gains from increasing their utilization. METHODS: The study consisted of two steps. First, we reviewed cost-utility analyses (CUAs) related to diabetes published through the end of 2012, using the Tufts Medical Center Cost-Effectiveness Analysis Registry ( We used logistic regression to examine factors independently associated with favorable cost-effective ratios...
March 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Michael P Bancks, Andrew O Odegaard, Woon-Puay Koh, Jian-Min Yuan, Myron D Gross, Mark A Pereira
BACKGROUND: The American Diabetes Association recently included glycated hemoglobin in the diagnostic criteria for diabetes, but research on the utility of this biomarker in Southeast Asians is scant. The aim of this study was to evaluate the association between percent HbA1c and incident diabetes in an Asian population of adult men and women without reported diabetes. METHODS: Data analysis of 5,770 men and women enrolled in the Singapore Chinese Health Study who provided a blood sample at the follow-up I visit (1999-2004) and had no cancer and no reported history of diabetes or cardiovascular disease events...
2015: PloS One
Vanessa L Z Gordon-Dseagu, Jennifer S Mindell, Andrew Steptoe, Alison Moody, Jane Wardle, Panayotes Demakakos, Nicola J Shelton
BACKGROUND: The extent that controlled diabetes impacts upon mortality, compared with uncontrolled diabetes, and how pre-diabetes alters mortality risk remain issues requiring clarification. METHODS: We carried out a cohort study of 22,106 Health Survey for England participants with a HbA1C measurement linked with UK mortality records. We estimated hazard ratios (HRs) of all-cause, cancer and cardiovascular disease (CVD) mortality and 95% confidence intervals (CI) using Cox regression...
2015: PloS One
Jennifer R Law, Jeanette M Stafford, Ralph B D'Agostino, Angela Badaru, Tessa L Crume, Dana Dabelea, Lawrence M Dolan, Jean M Lawrence, David J Pettitt, Elizabeth J Mayer-Davis
AIMS: Determine if parental diabetes (DM) is associated with unhealthier cardiovascular disease (CVD) risk profiles in youth with type 2 diabetes (T2D), and whether associations differed by race/ethnicity. METHODS: Family history was available for 382 youth with T2D from 2001 prevalent and 2002-2005 incident SEARCH for Diabetes in Youth cohorts. Parental DM was evaluated in two ways: two-category-any parent vs. no parent DM (evaluated overall and stratified by race/ethnicity); and four-category-both parents, mother only, father only, or no parent DM (evaluated overall only)...
May 2015: Journal of Diabetes and its Complications
Jacob A Udell, Matthew A Cavender, Deepak L Bhatt, Saurav Chatterjee, Michael E Farkouh, Benjamin M Scirica
BACKGROUND: Some glucose-lowering drugs or strategies adversely affect cardiovascular outcomes. We aimed to assess the extent to which glucose lowering by various drugs or strategies increases the risk of heart failure in patients with or at risk for type 2 diabetes, and to establish whether risk is associated with achieved differences in glycaemia or weight control. METHODS: We searched Ovid Medline, the Cochrane Library, and meeting abstracts up to Feb 20, 2015, for large randomised controlled trials of glucose-lowering drugs or strategies that assessed cardiovascular outcomes...
May 2015: Lancet Diabetes & Endocrinology
Pedro Iglesias, J Pedro-Botet, Francisco Arrieta, Manuel Aguilar, Fernando Escobar On Behalf Of The Working Group On Diabetes And Cardiovascular Disease Of The Spanish Society Of Diabetes
The prevalence of type 2 diabetes mellitus (T2DM) has risen in recent decades, and cardiovascular disease (CVD) remains the leading cause of death in this population. Several studies have shown that, in clinical practice, identifying diabetic patients at high risk for CVD is essential, since these patients benefit from aggressive strategies to achieve a greater risk reduction. In recent years, new markers of CV risk have been added to the list of those already known. These new emerging markers, such as inflammatory, bone and hormonal markers, act as new indicators of subclinical atherosclerosis and CV mortality...
2015: Current Diabetes Reviews
Ruwei Hu, Leiyu Shi, Geraldine Pierre, Jinsheng Zhu, De-Chih Lee
AIMS: This research presents a comprehensive picture of medical spending associated with diabetes in the United States, accounting for important population characteristics. METHODS: The Household Component (HC) of the 2010 Medical Expenditure Panel Survey (MEPS) was used for this study. Regression analysis was used to compare medical spending between individuals with and without diabetes. The dependent variables of interest were total and out-of-pocket expenditures related to medical care, hospital use, physician office visits, and prescription drug use...
May 2015: Diabetes Research and Clinical Practice
Paola Ballotari, Stefania Caroli, Francesca Ferrari, Gabriele Romani, Greci Marina, Antonio Chiarenza, Valeria Manicardi, Paolo Giorgi Rossi
BACKGROUND: The diabetes prevalence increases at an alarming rate around the world and understanding disparities in occurrence, care management, and health outcomes may be a starting point towards achieving more effective strategies to prevent and manage it. The aims of this study are to compare immigrants and Italians in terms of the differences in diabetes prevalence and to evaluate inequalities in disease management and glycaemic control by using information included in Reggio Emilia diabetes register...
December 2015: BMC Public Health
Charles E Sepers, Stephen B Fawcett, Ruth Lipman, Jerry Schultz, Vicki Colie-Akers, Alexandra Perez
PURPOSE: The purpose of this study is to measure the implementation and effects of a multisite coordinated care approach that delivered diabetes self-management education (DSME) and diabetes self-management support (DSMS) for disadvantaged patients within 4 patient-centered medical homes (PCMH). METHODS: A total of 173 patients (69.9% African American, 26.0% Caucasian, and 4.1% other) experienced elements of the intervention, which featured DSME and coordinated care...
June 2015: Diabetes Educator
Giulio R Romeo, Martin J Abrahamson
No abstract text is available yet for this article.
June 2, 2015: Annals of Internal Medicine
Michael L Christensen, Brandi E Franklin, Jeremiah D Momper, Michael D Reed
Considerable progress has been made in pediatric drug development. Despite these gains there remain certain therapeutic areas where a high percentage of drugs approved for use in adults do not gain approval for use in children. Lack of sufficient US Food and Drug Administration (FDA)-approved labeling correlates with diminished therapeutic efficacy and increased risk for adverse drug reactions. Despite the increasing prevalence and important clinical challenge with pediatric type 2 diabetes mellitus (T2DM), only 1 drug (metformin) of the first 4 T2DM drugs to complete testing in children gained FDA approval...
July 2015: Journal of Clinical Pharmacology
Hanri Afghahi, Maria K Svensson, Mirnabi Pirouzifard, Björn Eliasson, Ann-Marie Svensson
AIMS/HYPOTHESIS: We assessed the relationship between BP and risk of cardiovascular events (CVEs) and all-cause mortality in patients with type 2 diabetes and renal impairment (estimated GFR < 60 ml min(-1) 1.73 m(-2)) treated in clinical practice. METHODS: A total of 33,356 patients (aged 75 ± 9 years, diabetes duration of 10 ± 8 years) with at least one serum creatinine and BP value available in the Swedish National Diabetes Register between 2005 and 2007 were followed up until 2011 or death...
June 2015: Diabetologia
2015-03-23 15:43:51
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