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RANDOMIZED CONTROLLED TRIAL
Paula A Tähtinen, Miia K Laine, Pentti Huovinen, Jari Jalava, Olli Ruuskanen, Aino Ruohola
BACKGROUND: The efficacy of antimicrobial treatment in children with acute otitis media remains controversial. METHODS: In this randomized, double-blind trial, children 6 to 35 months of age with acute otitis media, diagnosed with the use of strict criteria, received amoxicillin-clavulanate (161 children) or placebo (158 children) for 7 days. The primary outcome was the time to treatment failure from the first dose until the end-of-treatment visit on day 8. The definition of treatment failure was based on the overall condition of the child (including adverse events) and otoscopic signs of acute otitis media...
January 13, 2011: New England Journal of Medicine
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