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IVF physiology

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2 papers 0 to 25 followers
Jacqueline A Maybin, Hilary O D Critchley
BACKGROUND: Each month the endometrium becomes inflamed, and the luminal portion is shed during menstruation. The subsequent repair is remarkable, allowing implantation to occur if fertilization takes place. Aberrations in menstrual physiology can lead to common gynaecological conditions, such as heavy or prolonged bleeding. Increased knowledge of the processes involved in menstrual physiology may also have translational benefits at other tissue sites. METHODS: Pubmed and Cochrane databases were searched for all original and review articles published in English until April 2015...
November 2015: Human Reproduction Update
Aaron J W Hsueh, Kazuhiro Kawamura, Yuan Cheng, Bart C J M Fauser
Although hormonal regulation of ovarian follicle development has been extensively investigated, most studies concentrate on the development of early antral follicles to the preovulatory stage, leading to the successful use of exogenous FSH for infertility treatment. Accumulating data indicate that preantral follicles are under stringent regulation by FSH and local intraovarian factors, thus providing the possibility to develop new therapeutic approaches. Granulosa cell-derived C-type natriuretic factor not only suppresses the final maturation of oocytes to undergo germinal vesicle breakdown before ovulation but also promotes preantral and antral follicle growth...
February 2015: Endocrine Reviews
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