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RANDOMIZED CONTROLLED TRIAL
Glenn R Cunningham, Alisa J Stephens-Shields, Raymond C Rosen, Christina Wang, Susan S Ellenberg, Alvin M Matsumoto, Shalender Bhasin, Mark E Molitch, John T Farrar, David Cella, Elizabeth Barrett-Connor, Jane A Cauley, Denise Cifelli, Jill P Crandall, Kristine E Ensrud, Laura Fluharty, Thomas M Gill, Cora E Lewis, Marco Pahor, Susan M Resnick, Thomas W Storer, Ronald S Swerdloff, Stephen Anton, Shehzad Basaria, Susan Diem, Vafa Tabatabaie, Xiaoling Hou, Peter J Snyder
CONTEXT: The prevalence of sexual dysfunction, low vitality, and poor physical function increases with aging, as does the prevalence of low total and free testosterone (TT and FT) levels. However, the relationship between sex hormones and age-related alterations in older men is not clear. OBJECTIVE: To test the hypotheses that baseline serum TT, FT, estradiol (E2), and sex hormone-binding globulin (SHBG) levels are independently associated with sexual function, vitality, and physical function in older symptomatic men with low testosterone levels participating in the Testosterone Trials (TTrials)...
March 2015: Journal of Clinical Endocrinology and Metabolism
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