Nigel S Beckett, Ruth Peters, Astrid E Fletcher, Jan A Staessen, Lisheng Liu, Dan Dumitrascu, Vassil Stoyanovsky, Riitta L Antikainen, Yuri Nikitin, Craig Anderson, Alli Belhani, Françoise Forette, Chakravarthi Rajkumar, Lutgarde Thijs, Winston Banya, Christopher J Bulpitt
BACKGROUND: Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death. METHODS: We randomly assigned 3845 patients from Europe, China, Australasia, and Tunisia who were 80 years of age or older and had a sustained systolic blood pressure of 160 mm Hg or more to receive either the diuretic indapamide (sustained release, 1...
May 1, 2008: New England Journal of Medicine