Anette Varbo, Marianne Benn, George Davey Smith, Nicholas J Timpson, Anne Tybjaerg-Hansen, Børge G Nordestgaard
RATIONALE: Obesity leads to increased ischemic heart disease (IHD) risk, but the risk is thought to be mediated through intermediate variables and may not be caused by increased weight per se. OBJECTIVE: To test the hypothesis that the increased IHD risk because of obesity is mediated through lipoproteins, blood pressure, glucose, and C-reactive protein. METHODS AND RESULTS: Approximately 90 000 participants from Copenhagen were included in a Mendelian randomization design with mediation analyses...
February 13, 2015: Circulation Research