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Coronary Diseases 2015

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21 papers 25 to 100 followers Coronary Disease 2015
By A Tajlil Physician
Irene R Dégano, Isaac Subirana, Marina Torre, María Grau, Joan Vila, Danilo Fusco, Inge Kirchberger, Jean Ferrières, Antti Malmivaara, Ana Azevedo, Christa Meisinger, Vanina Bongard, Dimitros Farmakis, Marina Davoli, Unto Häkkinen, Carla Araújo, John Lekakis, Roberto Elosua, Jaume Marrugat
BACKGROUND: Hospital performance models in acute myocardial infarction (AMI) are useful to assess patient management. While models are available for individual countries, mainly US, cross-European performance models are lacking. Thus, we aimed to develop a system to benchmark European hospitals in AMI and percutaneous coronary intervention (PCI), based on predicted in-hospital mortality. METHODS AND RESULTS: We used the EURopean HOspital Benchmarking by Outcomes in ACS Processes (EURHOBOP) cohort to develop the models, which included 11,631 AMI patients and 8276 acute coronary syndrome (ACS) patients who underwent PCI...
March 1, 2015: International Journal of Cardiology
Rami Khayat, David Jarjoura, Kyle Porter, Angela Sow, Jacob Wannemacher, Robert Dohar, Adam Pleister, William T Abraham
BACKGROUND: Hospitalizations for heart failure are associated with a high post-discharge risk for mortality. Identification of modifiable predictors of post-discharge mortality during hospitalization may improve outcome. Sleep disordered breathing (SDB) is the most common co-morbidity in heart failure patients. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of patients hospitalized with acute heart failure (AHF) in a single academic heart hospital. Between January 2007 and December 2010, all patients hospitalized with AHF who have left ventricular ejection fraction (LVEF) ≤ 45% and were not already diagnosed with SDB were the target population...
June 14, 2015: European Heart Journal
Kazuyuki Yahagi, Harry R Davis, Eloisa Arbustini, Renu Virmani
Cardiovascular disease (CVD) remains the most frequent cause of death in both men and women. Many studies on CVD have included mostly men, and the knowledge about coronary artery disease (CAD) in women has largely been extrapolated from studies primarily focused on men. The influence of various risk factors is different between men and women; untoward effects of smoking of CAD are greater in women than men. Furthermore, the effect of the menopause is important in women, with higher incidence of plaque erosion in young women versus greater incidence of plaque rupture in older women...
March 2015: Atherosclerosis
R-F Yang, X-Y Liu, Z Lin, G Zhang
OBJECTIVE: Coronary disease is analyzed through common lipid profiles, but these analyses fail to account for residual risk due to abdominal weight and elevated TG levels. We aimed to investigate the relationship between the waist circumference × triglyceride index (WT index) and the Coronary Artery Score (CAS) in patients with coronary heart disease. PATIENTS AND METHODS: 346 patients in our Cardiology Department were recruited from September 2007 to August 2011 and divided into two groups according to whether the patients presented with metabolic syndrome...
January 2015: European Review for Medical and Pharmacological Sciences
Gyung-Min Park, Hyonggin An, Seung-Whan Lee, Young-Rak Cho, Eun Ha Gil, Sung Ho Her, Young-Hak Kim, Cheol Whan Lee, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Ki-Up Lee, Joon-Won Kang, Tae-Hwan Lim, Seong-Wook Park, Seung-Jung Park, Joong-Yeol Park
No model has been developed to predict significant coronary artery disease (CAD) on coronary computed tomographic angiography (CCTA) in asymptomatic type 2 diabetes. Therefore, we sought to develop a model for the prediction of significant CAD on CCTA in these patients. We analyzed 607 asymptomatic patients with type 2 diabetes who underwent CCTA. The cardiac event was defined as a composite of cardiac death, nonfatal myocardial infarction, acute coronary syndrome, and coronary revascularization. Significant CAD (diameter stenosis ≥50%) in at least one coronary artery on CCTA was observed in 188 (31...
January 2015: Medicine (Baltimore)
Sergio Raposeiras-Roubín, Emad Abu-Assi, Andrea López-López, Noelia Bouzas-Cruz, María Castiñeira-Busto, Cristina Cambeiro-González, Belén Álvarez-Álvarez, Alejandro Virgós-Lamela, Alfonso Varela-Román, José María García-Acuña, José Ramón González-Juanatey
BACKGROUND: Despite encouraging declines in the incidence of heart failure (HF) complicating acute coronary syndrome (ACS), it remains a common problem with high mortality. Being able to identify patients at high risk of HF after ACS would have great clinical and economic impact. With this study, we assessed the usefulness of the GRACE score to predict HF after an ACS. METHODS: We studied 4137 consecutive patients discharged with diagnosis of ACS. We analyzed HF incidence, timing, and association with the follow-up mortality...
September 2015: Journal of Cardiology
Andrew J Foy, Guodong Liu, William R Davidson, Christopher Sciamanna, Douglas L Leslie
IMPORTANCE: Patients presenting to the emergency department (ED) with chest pain whose evaluation for ischemia demonstrates no abnormalities receive further functional or anatomical studies for coronary artery disease; however, comparative evidence for the various strategies is lacking and multiple testing options exist. OBJECTIVE: To compare chest pain evaluation pathways based on their association with downstream testing, interventions, and outcomes for patients in EDs...
March 2015: JAMA Internal Medicine
Aviroop Biswas, Paul I Oh, Guy E Faulkner, Ravi R Bajaj, Michael A Silver, Marc S Mitchell, David A Alter
BACKGROUND: The magnitude, consistency, and manner of association between sedentary time and outcomes independent of physical activity remain unclear. PURPOSE: To quantify the association between sedentary time and hospitalizations, all-cause mortality, cardiovascular disease, diabetes, and cancer in adults independent of physical activity. DATA SOURCES: English-language studies in MEDLINE, PubMed, EMBASE, CINAHL, Cochrane Library, Web of Knowledge, and Google Scholar databases were searched through August 2014 with hand-searching of in-text citations and no publication date limitations...
January 20, 2015: Annals of Internal Medicine
Yanmei Chen, He Wang, Yongkang Lu, Xiaobo Huang, Yulin Liao, Jianping Bin
BACKGROUND: Mineralocorticoid receptor antagonists (MRAs) have been shown to be effective in patients with heart failure or myocardial infarction complicated by a reduced ejection fraction. However, the role of MRAs in patients with preserved ejection fraction (PEF) remains to be clarified. We aimed to summarize the evidence for the efficacy of MRAs in patients with either heart failure with PEF (HF-PEF) or myocardial infarction with PEF (MI-PEF). METHODS: We searched PubMed, EMBASE, Cochrane Library, and clinical trials databases for randomized controlled trials, through June 2014, assessing MRA treatment in HF-PEF or MI-PEF patients...
2015: BMC Medicine
Reshmi Srinath, Sherita Hill Golden, Kathryn A Carson, Adrian Dobs
CONTEXT: Epidemiologic studies suggest that endogenous testosterone (T) levels in males may be implicated in cardiovascular disease (CVD), however further clarification is needed. OBJECTIVE: We assessed the cross-sectional relationship between endogenous plasma T and mean carotid intima media thickness (cIMT), and the longitudinal relationship with incident clinical CVD events, cardiac mortality, and all-cause mortality using male participants in the Atherosclerosis Risk in Communities (ARIC) study...
April 2015: Journal of Clinical Endocrinology and Metabolism
Urban Alehagen, Lina Benson, Magnus Edner, Ulf Dahlström, Lars H Lund
BACKGROUND: In heart failure (HF) with reduced ejection fraction, randomized trials of statins did not demonstrate improved outcomes. However, randomized trials may not always be generalizable. The aim was to determine whether statins are associated with improved outcomes in an unselected nationwide population of patients with HF with reduced ejection fraction overall and in relation to ischemic heart disease (IHD). METHODS AND RESULTS: In the Swedish Heart Failure Registry, 21 864 patients with HF with reduced ejection fraction (age ± SD, 72±12 years; 29% women), of whom 10 345 (47%) were treated with statins, were studied...
March 2015: Circulation. Heart Failure
Caroline Marie Patterson, Arjun Nair, Nabeel Ahmed, Leoni Bryan, Derek Bell, Edward David Nicol
OBJECTIVE: To describe the clinical outcomes of patients for whom National Institute for Health and Care Excellence (NICE) recent-onset chest pain guidance would not have recommended further investigation, compared with those of patients where further investigation would have been recommended. METHODS: 557 consecutive patients with recent-onset chest pain attending rapid-access chest pain clinics (RACPC) in two district general hospitals over a 9-month period were retrospectively reviewed...
January 2015: Heart: Official Journal of the British Cardiac Society
Mohammad El Tahlawi, Mohammad Abdelbaset, Mohammad Gouda, Ikhlas Hussein
The roles of arterial function and structure in cardiovascular physiology have expanded with the development of a variety of parameters that evaluate arterial stiffness. Markers of arterial stiffness have been correlated with cardiovascular outcomes. We aimed to find a simple, clinical, noninvasive method to predict atherosclerosis that leads to the development of coronary artery disease (CAD). We aimed to find a simple, clinical, noninvasive method to predict atherosclerosis that leads to the development of CAD...
April 2015: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Hamdi Boubaker, Mohamed Habib Grissa, Kaouther Beltaief, Mohamed Haj Amor, Zouhaier Mdimagh, Amor Boukhris, Mehdi Ben Amor, Zohra Dridi, Mondher Letaief, Wahid Bouida, Riadh Boukef, Fadhel Najjar, Semir Nouira
BACKGROUND: Acute coronary syndrome (ACS) represents a difficult diagnostic challenge in patients with undifferentiated chest pain. There is a need for a valid clinical score to improve diagnostic accuracy. OBJECTIVES: To compare the performance of a model combining the Thrombolysis in Myocardial Infarction (TIMI) score and a score describing chest pain (ACS diagnostic score: ACSD score) with that of both scores alone in the diagnosis of ACS in ED patients with chest pain associated with a non-diagnostic ECG and normal troponin...
October 2015: Emergency Medicine Journal: EMJ
Prediman K Shah, Kuang-Yuh Chyu, Paul C Dimayuga, Jan Nilsson
Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in atherosclerosis. Hence, it is conceivable that an immunomodulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. This review discusses: 1) the complex role of important components of the innate and adaptive immune systems in atherogenesis; 2) the nature of many antigens that have been tested successfully in vaccine formulations to reduce atherosclerosis in pre-clinical experimental models; and 3) the potential opportunities and challenges for clinical application of vaccination for atherosclerosis in the future...
December 30, 2014: Journal of the American College of Cardiology
Sami M A Alnasser, Wei Huang, Joel M Gore, Ph Gabriel Steg, Kim A Eagle, Frederick A Anderson, Keith A A Fox, Enrique Gurfinkel, David Brieger, Werner Klein, Frans van de Werf, Álvaro Avezum, Gilles Montalescot, Dietrich C Gulba, Andrzej Budaj, Jose Lopez-Sendon, Christopher B Granger, Brian M Kennelly, Robert J Goldberg, Emily Fleming, Shaun G Goodman
PURPOSE: Short-term outcomes have been well characterized in acute coronary syndromes; however, longer-term follow-up for the entire spectrum of these patients, including ST-segment-elevation myocardial infarction, non-ST-segment-elevation myocardial infarction, and unstable angina, is more limited. Therefore, we describe the longer-term outcomes, procedures, and medication use in Global Registry of Acute Coronary Events (GRACE) hospital survivors undergoing 6-month and 2-year follow-up, and the performance of the discharge GRACE risk score in predicting 2-year mortality...
July 2015: American Journal of Medicine
Johan Sundström, Hisatomi Arima, Rod Jackson, Fiona Turnbull, Kazem Rahimi, John Chalmers, Mark Woodward, Bruce Neal
BACKGROUND: Effects of blood pressure reduction in persons with grade 1 hypertension are unclear. PURPOSE: To investigate whether pharmacologic blood pressure reduction prevents cardiovascular events and deaths in persons with grade 1 hypertension. DATA SOURCES: Trials included in the BPLTTC (Blood Pressure Lowering Treatment Trialists' Collaboration) and trials identified from a previous review and electronic database searches. STUDY SELECTION: Patients without cardiovascular disease with blood pressures in the grade 1 hypertension range (140 to 159/90 to 99 mm Hg) who were randomly assigned to an active (antihypertensive drug or more intensive regimen) or control (placebo or less intensive regimen) blood pressure-lowering regimen...
February 3, 2015: Annals of Internal Medicine
Giampaolo Niccoli, Giancarla Scalone, Filippo Crea
Myocardial infarction (MI) with no obstructive coronary atherosclerosis (MINOCA) is a syndrome with different causes. Its prevalence ranges between 5 and 25% of all MIs. The prognosis is extremely variable, depending on the causes of MINOCA. Clinical history, echocardiography, coronary angiography, and left ventriculography represent the first-level diagnostic investigations. Nevertheless, additional tests are required in order to establish its specific cause, thus allowing an appropriate risk stratification and treatment...
February 21, 2015: European Heart Journal
Dariush Mozaffarian, Emelia J Benjamin, Alan S Go, Donna K Arnett, Michael J Blaha, Mary Cushman, Sarah de Ferranti, Jean-Pierre Després, Heather J Fullerton, Virginia J Howard, Mark D Huffman, Suzanne E Judd, Brett M Kissela, Daniel T Lackland, Judith H Lichtman, Lynda D Lisabeth, Simin Liu, Rachel H Mackey, David B Matchar, Darren K McGuire, Emile R Mohler, Claudia S Moy, Paul Muntner, Michael E Mussolino, Khurram Nasir, Robert W Neumar, Graham Nichol, Latha Palaniappan, Dilip K Pandey, Mathew J Reeves, Carlos J Rodriguez, Paul D Sorlie, Joel Stein, Amytis Towfighi, Tanya N Turan, Salim S Virani, Joshua Z Willey, Daniel Woo, Robert W Yeh, Melanie B Turner
No abstract text is available yet for this article.
January 27, 2015: Circulation
2014-12-21 02:21:38
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