Stefanie Lerche, Klaus Seppi, Stefanie Behnke, Inga Liepelt-Scarfone, Jana Godau, Philipp Mahlknecht, Alexandra Gaenslen, Kathrin Brockmann, Karin Srulijes, Heiko Huber, Isabel Wurster, Heike Stockner, Stefan Kiechl, Johann Willeit, Arno Gasperi, Klaus Fassbender, Werner Poewe, Daniela Berg
Identification of risk factors and prodromal markers for Parkinson's disease (PD) and the understanding of the point in time of first occurrence is essential for the early detection of incident PD. In this three-center longitudinal, observational study, we evaluated the specific risk for PD associated with single or combinations of risk factors and prodromal markers. In addition, we evaluated which risk factors and prodromal markers emerge at which time before the diagnosis of PD. Of the 1,847 at-baseline PD-free individuals ≥ 50 years, 1,260 underwent the 5-year follow-up assessment...
January 2014: Journal of Neurology