collection
https://read.qxmd.com/read/23065822/insulin-resistance-and-the-polycystic-ovary-syndrome-revisited-an-update-on-mechanisms-and-implications
#41
REVIEW
Evanthia Diamanti-Kandarakis, Andrea Dunaif
Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected women have marked insulin resistance, independent of obesity. This article summarizes the state of the science since we last reviewed the field in the Endocrine Reviews in 1997. There is general agreement that obese women with PCOS are insulin resistant, but some groups of lean affected women may have normal insulin sensitivity. There is a post-binding defect in receptor signaling likely due to increased receptor and insulin receptor substrate-1 serine phosphorylation that selectively affects metabolic but not mitogenic pathways in classic insulin target tissues and in the ovary...
December 2012: Endocrine Reviews
https://read.qxmd.com/read/25419673/summaries-for-patients-screening-for-vitamin-d-deficiency-in-adults-us-preventive-services-task-force-recommendation-statement
#42
(no author information available yet)
No abstract text is available yet for this article.
January 20, 2015: Annals of Internal Medicine
https://read.qxmd.com/read/25272316/goal-directed-resuscitation-for-patients-with-early-septic-shock
#43
RANDOMIZED CONTROLLED TRIAL
Sandra L Peake, Anthony Delaney, Michael Bailey, Rinaldo Bellomo, Peter A Cameron, D James Cooper, Alisa M Higgins, Anna Holdgate, Belinda D Howe, Steven A R Webb, Patricia Williams
BACKGROUND: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness is uncertain. METHODS: In this trial conducted at 51 centers (mostly in Australia or New Zealand), we randomly assigned patients presenting to the emergency department with early septic shock to receive either EGDT or usual care...
October 16, 2014: New England Journal of Medicine
https://read.qxmd.com/read/23174386/oxytocin-use-during-active-labor-too-much-of-a-good-thing
#44
EDITORIAL
Mona R Prasad, Edmund Funai
No abstract text is available yet for this article.
December 2012: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/25054715/don-t-learn-on-me-are-teaching-hospitals-patient-centered
#45
Brendan M Reilly
What she wants seems reasonable enough, a request I've heard from patients before. During my 40 years as a clinician-educator at academic medical centers, I've come to rely on a redoubtable reply: That's not the way we do things here. This is a teaching hospital. If you don't want residents or..
July 24, 2014: New England Journal of Medicine
https://read.qxmd.com/read/23493539/fructose-it-s-alcohol-without-the-buzz
#46
Robert H Lustig
What do the Atkins Diet and the traditional Japanese diet have in common? The Atkins Diet is low in carbohydrate and usually high in fat; the Japanese diet is high in carbohydrate and usually low in fat. Yet both work to promote weight loss. One commonality of both diets is that they both eliminate the monosaccharide fructose. Sucrose (table sugar) and its synthetic sister high fructose corn syrup consist of 2 molecules, glucose and fructose. Glucose is the molecule that when polymerized forms starch, which has a high glycemic index, generates an insulin response, and is not particularly sweet...
March 1, 2013: Advances in Nutrition
https://read.qxmd.com/read/18813052/a-rational-approach-to-perioperative-fluid-management
#47
REVIEW
Daniel Chappell, Matthias Jacob, Klaus Hofmann-Kiefer, Peter Conzen, Markus Rehm
Replacement of assumed preoperative deficits, in addition to generous substitution of an unsubstantiated increased insensible perspiration and third space loss, plays an important role in current perioperative fluid regimens. The consequence is a positive fluid balance and weight gain of up to 10 kg, which may be related to severe complications. Because the intravascular blood volume remains unchanged and insensible perspiration is negligible, the fluid must accumulate inside the body. This concept brings into question common liberal infusion regimens...
October 2008: Anesthesiology
https://read.qxmd.com/read/16135930/laparoscopic-versus-open-appendectomy-a-prospective-randomized-double-blind-study
#48
RANDOMIZED CONTROLLED TRIAL
Namir Katkhouda, Rodney J Mason, Shirin Towfigh, Anna Gevorgyan, Rahila Essani
SUMMARY BACKGROUND DATA: The value of laparoscopy in appendicitis is not established. Studies suffer from multiple limitations. Our aim is to compare the safety and benefits of laparoscopic versus open appendectomy in a prospective randomized double blind study. METHODS: Two hundred forty-seven patients were analyzed following either laparoscopic or open appendectomy. A standardized wound dressing was applied blinding both patients and independent data collectors...
September 2005: Annals of Surgery
https://read.qxmd.com/read/22696320/colloids-versus-crystalloids-for-fluid-resuscitation-in-critically-ill-patients
#49
REVIEW
Pablo Perel, Ian Roberts
BACKGROUND: Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids. OBJECTIVES: To assess the effects of colloids compared to crystalloids for fluid resuscitation in critically ill patients. SEARCH METHODS: We searched the Cochrane Injuries Group Specialised Register (searched 16 March 2012), Cochrane Central Register of Controlled Trials 2011, issue 3 (The Cochrane Library), MEDLINE (Ovid) 1946 to March 2012, Embase (Ovid) 1980 to March 2012, ISI Web of Science: Science Citation Index Expanded (1970 to March 2012), ISI Web of Science: Conference Proceedings Citation Index-Science (1990 to March 2012), PubMed (searched 16 March 2012), www...
June 13, 2012: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/23992943/does-calcium-administration-during-cardiopulmonary-resuscitation-improve-survival-for-patients-in-cardiac-arrest
#50
EDITORIAL
Adaira Landry, Mark Foran, Alex Koyfman
No abstract text is available yet for this article.
August 2014: Annals of Emergency Medicine
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