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Exogenous surfactant therapy in preterm infants

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Wolfgang Göpel, Angela Kribs, Christoph Härtel, Stefan Avenarius, Norbert Teig, Peter Groneck, Dirk Olbertz, Claudia Roll, Matthias Vochem, Ursula Weller, Axel von der Wense, Christian Wieg, Jürgen Wintgens, Michael Preuss, Andreas Ziegler, Bernhard Roth, Egbert Herting
AIM: Providing less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported to reduce mechanical ventilation and bronchopulmonary dysplasia (BPD) in randomised controlled trials. This large cohort study compared these outcome measures between LISA-treated infants and controls. METHODS: Infants receiving LISA, who were born before 32 gestational weeks and enrolled in the German Neonatal Network, were matched to control infants by gestational age, umbilical cord pH, Apgar-score at 5 min, small for gestational age status, antenatal treatment with steroids, gender and highest supplemental oxygen during the first 12 h of life...
March 2015: Acta Paediatrica
Richard A Polin, Waldemar A Carlo
Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and mortality in preterm infants. Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. Secondary surfactant deficiency also contributes to acute respiratory morbidity in late-preterm and term neonates with meconium aspiration syndrome, pneumonia/sepsis, and perhaps pulmonary hemorrhage; surfactant replacement may be beneficial for these infants. This statement summarizes the evidence regarding indications, administration, formulations, and outcomes for surfactant-replacement therapy...
January 2014: Pediatrics
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