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MULTICENTER STUDY
Dale M Needham, Ting Yang, Victor D Dinglas, Pedro A Mendez-Tellez, Carl Shanholtz, Jonathan E Sevransky, Roy G Brower, Peter J Pronovost, Elizabeth Colantuoni
RATIONALE: Reducing tidal volume decreases mortality in acute respiratory distress syndrome (ARDS). However, the effect of the timing of low tidal volume ventilation is not well understood. OBJECTIVES: To evaluate the association of intensive care unit (ICU) mortality with initial tidal volume and with tidal volume change over time. METHODS: Multivariable, time-varying Cox regression analysis of a multisite, prospective study of 482 patients with ARDS with 11,558 twice-daily tidal volume assessments (evaluated in milliliter per kilogram of predicted body weight [PBW]) and daily assessment of other mortality predictors...
January 15, 2015: American Journal of Respiratory and Critical Care Medicine
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