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14 papers 100 to 500 followers
Sohrab Khatab, Gerben M van Buul, Nicole Kops, Yvonne M Bastiaansen-Jenniskens, P Koen Bos, Jan A Verhaar, Gerjo J van Osch
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease leading to pain and disability for which no curative treatment exists. A promising biological treatment for OA is intra-articular administration of platelet-rich plasma (PRP). PRP injections in OA joints can relieve pain, although the exact working mechanism is unclear. PURPOSE: To examine the effects of PRP releasate (PRPr) on pain, cartilage damage, and synovial inflammation in a mouse OA model. STUDY DESIGN: Controlled laboratory study...
March 2018: American Journal of Sports Medicine
Wen-Li Dai, Ai-Guo Zhou, Hua Zhang, Jian Zhang
PURPOSE: To use meta-analysis techniques to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections for the treatment knee of osteoarthritis (OA). METHODS: We performed a systematic literature search in PubMed, Embase, Scopus, and the Cochrane database through April 2016 to identify Level I randomized controlled trials that evaluated the clinical efficacy of PRP versus control treatments for knee OA. The primary outcomes were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function scores...
March 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
Bryan M Saltzman, Timothy Leroux, Maximilian A Meyer, Bryce A Basques, Jaskarndip Chahal, Bernard R Bach, Adam B Yanke, Brian J Cole
BACKGROUND: Intra-articular normal saline (IA-NS) injections have been utilized as a placebo in a number of randomized controlled trials pertaining to the management of knee osteoarthritis (OA); however, it is believed that these "placebo" injections may have a therapeutic effect that has not been quantified in the literature. PURPOSE: To (1) quantify the effect of IA-NS injections on patient-reported outcomes (PROs) and (2) compare postinjection PROs to established minimal clinically important difference (MCID) criteria to demonstrate a potential therapeutic effect...
September 2017: American Journal of Sports Medicine
Aleyda A Loredo-Pérez, Carlos E Montalvo-Blanco, Luis I Hernández-González, Maricruz Anaya-Reyes, Cecilia Fernández Del Valle-Laisequilla, Juan G Reyes-García, Rosa I Acosta-González, Arisai Martínez-Martínez, Jaira C Villarreal-Salcido, Virginia M Vargas-Muñoz, Enriqueta Muñoz-Islas, Martha B Ramírez-Rosas, Juan M Jiménez-Andrade
OBJECTIVE: Our aim was to quantify nociceptive spontaneous behaviors, knee edema, proinflammatory cytokines, bone density, and microarchitecture in high-fat diet (HFD)-fed mice with unilateral knee arthritis. METHODS: ICR male mice were fed either standard diet (SD) or HFD starting at 3 weeks old. At 17 weeks, HFD and SD mice received intra-articular injections either with Complete Freund's Adjuvant (CFA) or saline into the right knee joint every 7 days for 4 weeks...
May 2016: Obesity
Rena C Zuo, Daniella M Schwartz, Chyi-Chia Richard Lee, Milan J Anadkat, Edward W Cowen, Haley B Naik
Key teaching points • Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by distinctive osteoarticular manifestations and a spectrum of neutrophilic dermatoses. • The most common dermatologic manifestations include palmoplantar pustulosis, acne conglobata, and acne fulminans. • SAPHO syndrome should be considered in patients presenting osteoarticular pain, particularly involving the anterior chest wall and/or spine, and neutrophilic skin lesions.
March 2015: Journal of the American Academy of Dermatology
L Xu, Z Li, S-Y Liu, S-Y Xu, G-X Ni
OBJECTIVE: To provide an overview of the literature describing the role of asporin, a small leucine-rich proteoglycan (SLRP), in osteoarthritis (OA). METHOD: A literature search was performed and reviewed using the narrative approach. RESULTS: As a class I SLRP member, asporin, is distinct from other SLRPs. Accumulating evidence demonstrates the involvement of asporin in OA pathogenesis. Many human studies have been conducted to explore the association between the D-repeat polymorphisms and OA susceptibility, but these yield inconsistent results...
June 2015: Osteoarthritis and Cartilage
J J Edwards, M Khanna, K P Jordan, J L Jordan, J Bedson, K S Dziedzic
OBJECTIVE: To identify valid and feasible quality indicators for the primary care of osteoarthritis (OA). DESIGN: Systematic review and narrative synthesis. DATA SOURCES: Electronic reference databases (MEDLINE, EMBASE, CINAHL, HMIC, PsychINFO), quality indicator repositories, subject experts. ELIGIBILITY CRITERIA: Eligible articles referred to adults with OA, focused on development or implementation of quality indicators, and relevant to UK primary care...
March 2015: Annals of the Rheumatic Diseases
Ryo Tanaka, Junya Ozawa, Nobuhiro Kito, Hideki Moriyama
OBJECTIVE: To examine the effect of exercise therapy on the walking ability of individuals with knee osteoarthritis. DATA SOURCES: Randomised clinical trials (RCTs) were identified by searching through PubMed, Cochrane Central Register of Controlled Trials, Physiotherapy Evidence Database, and Cumulative Index to Nursing and Allied Health Literature. All literature published to October 2014 were included in the search. REVIEW METHODS: Data were collected from RCTs that compared the effects of exercise therapy on walking ability with the effects of no intervention or psychoeducational intervention in participants with knee osteoarthritis...
January 2016: Clinical Rehabilitation
Han-Gyul Yoo, Wan-Hee Yoo
A 65-year-old woman presented with pain in both knees. She had received a diagnosis of osteoarthritis of the knee previously and had been treated with analgesic agents and nonsteroidal antiinflammatory drugs. In addition, she was treated intermittently with intraarticular injection of a..
December 26, 2013: New England Journal of Medicine
M van der Esch, J Knoop, M van der Leeden, L D Roorda, W F Lems, D L Knol, J Dekker
OBJECTIVE: To identify and validate previously established phenotypes of knee osteoarthritis (OA) based on similarities in clinical patient characteristics. METHODS: Knee OA patients (N = 551) from the Amsterdam OA (AMS-OA) cohort provided data. Four clinical patient characteristics were assessed: upper leg muscle strength, body mass index (BMI), radiographic severity (Kellgren/Lawrence [KL] grade), and depressive mood (the Hospital Anxiety and Depression Scale [HADS] questionnaire)...
April 2015: Osteoarthritis and Cartilage
K M Ghosh, N Hunt, A Blain, K K Athwal, L Longstaff, A A Amis, S Rushton, D J Deehan
PURPOSE: The popliteus tendon is crucial to postero-lateral stability and prone to iatrogenic injury intra-operatively. Its role in the stability of the replaced knee remains contentious. The aim of this study was to use computer navigation to quantify the effect of popliteus sectioning on the 'envelope of laxity' (EoL) offered by a posterior-stabilised (PS) total knee arthroplasty (TKA) and compare with that of the native knee. METHODS: Loaded cadaveric legs were mounted on a purpose built rig...
June 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Stephen T Duncan, Michael S Khazzam, Jeremy M Burnham, Kurt P Spindler, Warren R Dunn, Rick W Wright
PURPOSE: The purpose of this study was to perform a systematic review of the available literature to define the level of quality evidence for determining the sensitivity and specificity of different radiographic views in detecting knee osteoarthritis and to determine the impact of different grading systems on the ability to detect knee osteoarthritis. METHODS: A systematic review of the literature was conducted to identify studies that evaluated the standing anteroposterior (AP) and 45° posteroanterior (PA) views for tibiofemoral and patellofemoral arthritis and those comparing the use of the Kellgren-Lawrence versus the joint space narrowing (JSN) radiographic grading systems using arthroscopy as the gold standard...
February 2015: Arthroscopy: the Journal of Arthroscopic & related Surgery
Jihad Al-Ajlouni, Abdalla Awidi, Osama Samara, Mahasan Al-Najar, Emad Tarwanah, Mohannad Saleh, Mohammad Awidi, Freh Abu Hassan, Mohammad Samih, Abdulbari Bener, Manar Dweik
OBJECTIVE: To explore the safety and benefit from intra-articular autologous platelet lysate (PL) injection in early and intermediate knee osteoarthritis. DESIGN: Open-label prospective study. SETTING: Laboratory. PATIENTS: Adult patients, aged 35 to 70 years, with a history of chronic pain or swelling on one or both knees and imaging findings (radiograph or magnetic resonance imaging) of degenerative changes in the joint of grade I or II on the Kellgren scale were included...
November 2015: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Gust Verbruggen, Ruth Wittoek, Bert Vander Cruyssen, Dirk Elewaut
BACKGROUND: Adalimumab blocks the action of tumor necrosis factor-α and reduces disease progression in rheumatoid arthritis and psoriatic arthritis. The effects of adalimumab in controlling progression of structural damage in erosive hand osteoarthritis (HOA) were assessed. METHODS: Sixty patients with erosive HOA on radiology received 40 mg adalimumab or placebo subcutaneously every two weeks during a 12-month randomized double-blind trial. Response was defined as the reduction in progression of structural damage according to the categorical anatomic phase scoring system...
June 2012: Annals of the Rheumatic Diseases
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