Henri Honka, Jarna C Hannukainen, Miikka Tarkia, Henry Karlsson, Virva Saunavaara, Paulina Salminen, Minna Soinio, Kirsi Mikkola, Nobu Kudomi, Vesa Oikonen, Merja Haaparanta-Solin, Anne Roivainen, Riitta Parkkola, Patricia Iozzo, Pirjo Nuutila
CONTEXT: Glucolipotoxicity is believed to induce pancreatic β-cell dysfunction in obesity. Previously, it has not been possible to study pancreatic metabolism and blood flow in humans. OBJECTIVE: The objective of the study was to investigate whether pancreatic metabolism and blood flow are altered in obesity using positron emission tomography (PET). In the preclinical part, the method was validated in animals. DESIGN: This was a cross-sectional study...
June 2014: Journal of Clinical Endocrinology and Metabolism