Harry Jarrett, Helene McNulty, Catherine F Hughes, Kristina Pentieva, J J Strain, Adrian McCann, Liadhan McAnena, Conal Cunningham, Anne M Molloy, Albert Flynn, Sinead M Hopkins, Geraldine Horigan, Ciara O'Connor, Janette Walton, Breige A McNulty, Michael J Gibney, Yvonne Lamers, Mary Ward
BACKGROUND: The generation of the active form of vitamin B-6, pyridoxal 5'-phosphate (PLP), in tissues is dependent upon riboflavin as flavin mononucleotide, but whether this interaction is important for maintaining vitamin B-6 status is unclear. OBJECTIVE: To investigate vitamin B-6 and riboflavin status, their metabolic interaction, and relationship with methylenetetrahydrofolate reductase (MTHFR) genotype in adulthood. METHODS: Data from 5612 adults aged 18-102 y were drawn from the Irish National Adult Nutrition Survey (NANS; population-based sample) and the Trinity-Ulster Department of Agriculture (TUDA) and Genovit cohorts (volunteer samples)...
December 19, 2022: American Journal of Clinical Nutrition