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Naturopathic Medicine

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76 papers 1000+ followers Collection of RCTs and other papers + editorials
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://read.qxmd.com/read/31290226/carnosine-exhibits-significant-antiviral-activity-against-dengue-and-zika-virus
#1
Hussin A Rothan, Ammar Yasir Abdulrahman, Ahmad Suhail Khazali, Nurshamimi Nor Rashid, Teoh Teow Chong, Rohana Yusof
Dengue virus (DENV) and Zika virus (ZIKV) are flaviviruses transmitted to humans by their common vector, Aedes mosquitoes. DENV infection represents one of the most widely spread mosquito-borne diseases whereas ZIKV infection occasionally re-emerged in the past causing outbreaks. Although there have been considerable advances in understanding the pathophysiology of these viruses, no effective vaccines or antiviral drugs are currently available. In this study, we evaluated the antiviral activity of carnosine, an endogenous dipeptide (β-alanyl-l-histidine), against DENV serotype 2 (DENV2) and ZIKV infection in human liver cells (Huh7)...
July 9, 2019: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://read.qxmd.com/read/31268307/polycerasoidol-a-natural-prenylated-benzopyran-with-a-dual-ppar%C3%AE-ppar%C3%AE-agonist-activity-and-anti-inflammatory-effect
#2
Almudena Bermejo, Aida Collado, Isabel Barrachina, Patrice Marqués, Noureddine El Aouad, Xavier Franck, Franco Garibotto, Catherine Dacquet, Daniel H Caignard, Fernando D Suvire, Ricardo D Enriz, Laura Piqueras, Bruno Figadère, María-Jesús Sanz, Nuria Cabedo, Diego Cortes
Dual peroxisome proliferator-activated receptor-α/γ (PPARα/γ) agonists regulate both lipid and glucose homeostasis under different metabolic conditions and can exert anti-inflammatory activity. We investigated the potential dual PPARα/γ agonism of prenylated benzopyrans polycerasoidol (1) and polycerasoidin (2) and their derivatives for novel drug development. Nine semisynthetic derivatives were prepared from the natural polycerasoidol (1) and polycerasoidin (2), which were evaluated for PPARα, -γ, -δ and retinoid X receptor-α activity in transactivation assays...
July 3, 2019: Journal of Natural Products
https://read.qxmd.com/read/31287681/anthraquinone-based-specialized-metabolites-from-rhizomes-of-bulbine-natalensis
#3
Ji-Yeong Bae, Zulfiqar Ali, Yan-Hong Wang, Amar G Chittiboyina, Ahmed A Zaki, Alvaro M Viljoen, Ikhlas A Khan
The rhizomes of Bulbine natalensis furnished six previously unreported anthraquinone derivatives ( 1 - 6 ), together with eight known specialized metabolites. Their structures were determined by interpretation of 1D and 2D NMR and HRESIMS data. The absolute configurations of compounds 1 - 6 were determined by specific rotation and circular dichroism experiments. The isolated compounds were evaluated for antimicrobial activities, and compound 1 was found to be a moderate inhibitor (IC50 0.02 μM) against methicillin-resistant Staphylococcus aureus (MRSA)...
July 9, 2019: Journal of Natural Products
https://read.qxmd.com/read/31310122/triterpenoids-from-ganoderma-gibbosum-a-class-of-sensitizers-of-flc-resistant-candida-albicans-to-fluconazole
#4
Debing Pu, Xiaoning Li, Jing Lin, Ruihan Zhang, Ting Luo, Yuan Wang, Junbo Gao, Muhammad Aurang Zeb, Xingjie Zhang, Xiaoli Li, Ruirui Wang, Weilie Xiao
Fungal drug resistance is a major health threat, and reports of clinical resistance worldwide are becoming increasingly common. In a research program to discover new molecules to help overcome this problem, 14 new lanostane-type triterpenoids, gibbosicolids A-G ( 2 - 8 ) and gibbosic acids I-O ( 9 - 15 ), were isolated from the fruiting bodies of Ganoderma gibbosum , along with seven known triterpenoid derivatives. These compounds featured high levels of oxidation, epimerization, and γ-lactonization. Structures were elucidated by comprehensive spectroscopic analyses and HRMS data...
July 16, 2019: Journal of Natural Products
https://read.qxmd.com/read/30127751/food-for-mood-relevance-of-nutritional-omega-3-fatty-acids-for-depression-and-anxiety
#5
REVIEW
Thomas Larrieu, Sophie Layé
The central nervous system (CNS) has the highest concentration of lipids in the organism after adipose tissue. Among these lipids, the brain is particularly enriched with polyunsaturated fatty acids (PUFAs) represented by the omega-6 (ω6) and omega-3 (ω3) series. These PUFAs include arachidonic acid (AA) and docosahexaenoic acid (DHA), respectively. PUFAs have received substantial attention as being relevant to many brain diseases, including anxiety and depression. This review addresses an important question in the area of nutritional neuroscience regarding the importance of ω3 PUFAs in the prevention and/or treatment of neuropsychiatric diseases, mainly depression and anxiety...
2018: Frontiers in Physiology
https://read.qxmd.com/read/31238972/self-administered-acupressure-for-allergic-rhinitis-study-protocol-for-a-randomized-single-blind-non-specific-controlled-parallel-trial
#6
Yaqun Liang, George Binh Lenon, Angela Wei Hong Yang
BACKGROUND: Allergic rhinitis (AR) is an IgE-mediated inflammatory disease. Current conventional therapies for AR are unsatisfactory. Acupuncture has been recommended as an optional treatment for AR patients who are interested in non-pharmacotherapy in the new clinical practice guidelines for AR. Acupressure is a sub-type of acupuncture which is non-invasive with a low risk and can be self-administered. However, the current limited evidence is compromised by the high risk of bias and heterogeneity of methodology...
June 25, 2019: Trials
https://read.qxmd.com/read/31105918/b12-and-folate-concentrations-in-opium-addicts-compared-to-healthy-subjects-a-case-control-study-from-kerman-coronary-artery-disease-risk-study
#7
Ahmad Gholamhossenian, Beydolah Shahouzehi, Mostafa Shokoohi, Hamid Najafipour
Background: Opium addiction is a global problem which has implicated many societies. Opium addiction and drug abuse is related to harmful consequences which affect life style, biochemical factors, and vitamins values, and also is considered as a risk for heart diseases. Folate and B12 levels are related to homocysteine and studies about their levels in opium addicts are controversial; therefore, we designed this study to evaluate B12 and folate values in opium addicts. Methods: From the Kerman Coronary Artery Disease Risk Study (KERCADRS) which is a population-based study, we randomly selected 340 men and entered them into two groups: case (n = 170) and control group (n = 170)...
July 2018: Addiction & Health
https://read.qxmd.com/read/30815805/effectiveness-of-auricular-acupressure-for-acute-postoperative-pain-after-surgery-a-systematic-review-and-meta-analysis
#8
Qin Zhong, Di Wang, Ya-Mei Bai, Shi-Zheng Du, Yu-Lei Song, Jing Zhu
OBJECTIVE: To identify the effectiveness of auricular acupressure (AA) in patients with acute postoperative pain after surgery by systematic review. METHODS: A search of randomized controlled trials was conducted in 5 English medical electronic databases and 4 Chinese databases. Two reviewers independently retrieved related studies, assessed the methodological quality, and extracted data with a standardized data form. Meta-analyses were performed using all time-points meta-analysis...
March 2019: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/30932686/beyond-pills-acupressure-impact-on-self-rated-pain-and-anxiety-scores
#9
Elizabeth Monson, Diane Arney, Beth Benham, Rebekah Bird, Erika Elias, Kami Linden, Kimberly McCord, Cathy Miller, Tammy Miller, Lori Ritter, Deanna Waggy
Objectives: To determine impact of an acupressure protocol on self-rated pain and anxiety scores. Design: Retrospective database analysis of self-rated pain and anxiety scores before and immediately after administration of stress release acupressure protocol. Participants: Participants include hospitalized patients, nurses, and public. Intervention: Involves a 16-point stress release acupressure protocol. Outcome measures: Outcome measures involve pre- and post-treatment self-rated pain scores (0-10) with the Wong-Baker Faces Scale and pre- and post-treatment self-rated anxiety scores (0-10) on a visual analog scale...
May 2019: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://read.qxmd.com/read/30289748/role-of-phosphatidylcholine-dha-in-preventing-apoe4-associated-alzheimer-s-disease
#10
Rhonda P Patrick
Dietary and supplemental intake of the ω-3 fatty acid docosahexaenoic acid (DHA) reduces risk of Alzheimer's disease (AD) and ameliorates symptoms. The apolipoprotein E ( APOE) 4 allele is the strongest risk factor for sporadic AD, exclusive of age. APOE4 carriers respond well to the DHA present in fish but do not respond as well to dietary supplements. The mechanisms behind this varied response remain unknown. I posit that the difference is that fish contain DHA in phospholipid form, whereas fish oil supplements do not...
February 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/30838211/sport-nutrigenomics-personalized-nutrition-for-athletic-performance
#11
REVIEW
Nanci S Guest, Justine Horne, Shelley M Vanderhout, Ahmed El-Sohemy
An individual's dietary and supplement strategies can influence markedly their physical performance. Personalized nutrition in athletic populations aims to optimize health, body composition, and exercise performance by targeting dietary recommendations to an individual's genetic profile. Sport dietitians and nutritionists have long been adept at placing additional scrutiny on the one-size-fits-all general population dietary guidelines to accommodate various sporting populations. However, generic "one-size-fits-all" recommendations still remain...
2019: Frontiers in Nutrition
https://read.qxmd.com/read/30404216/benzylisoquinoline-alkaloids-biosynthesis-in-sacred-lotus
#12
REVIEW
Ivette M Menéndez-Perdomo, Peter J Facchini
Sacred lotus ( Nelumbo nucifera Gaertn.) is an ancient aquatic plant used throughout Asia for its nutritional and medicinal properties. Benzylisoquinoline alkaloids (BIAs), mostly within the aporphine and bisbenzylisoquinoline structural categories, are among the main bioactive constituents in the plant. The alkaloids of sacred lotus exhibit promising anti-cancer, anti-arrhythmic, anti-HIV, and anti-malarial properties. Despite their pharmacological significance, BIA metabolism in this non-model plant has not been extensively investigated...
November 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/20645801/anabolic-and-androgenic-activities-of-bulbine-natalensis-stem-in-male-wistar-rats
#13
COMPARATIVE STUDY
Musa T Yakubu, Anthony J Afolayan
Aqueous extract of Bulbine natalensis Baker (Asphodelaceae) stem at 25, 50 and 100 mg/kg body weight was investigated for anabolic and androgenic effects in male Wistar rats. Sixty male rats were grouped into four (A-D) consisting of 15 each. Group A (control) was orally treated with 0.5 mL of distilled water for 14 days while groups B, C and D were treated like the control except they received 0.5 mL containing 25, 50, and 100 mg/kg body weight of the extract respectively. All the doses of the extract increased (P <0...
May 2010: Pharmaceutical Biology
https://read.qxmd.com/read/30809139/rebound-or-entrainment-the-influence-of-alternating-current-stimulation-on-individual-alpha
#14
Linus Haberbosch, Sein Schmidt, Andreas Jooss, Arvid Köhn, Leonard Kozarzewski, Maria Rönnefarth, Michael Scholz, Stephan A Brandt
Alternating current stimulation (ACS) is an established means to manipulate intrinsic cortical oscillations. While working towards clinical impact, ACS mechanisms of action remain unclear. For ACS's well-documented influence on occipital alpha, hypotheses include neuronal entrainment as well as rebound phenomena. As a retinal origin is also discussed, we employed a novel form of ACS with the advantage that it specifically targets occipital alpha-oscillations via retinofugal pathways retinofugal ACS (rACS). We aimed to confirm alpha-enhancement outlasting the duration of stimulation with 10 Hz rACS...
2019: Frontiers in Human Neuroscience
https://read.qxmd.com/read/30809140/paired-associative-electroacupuncture-and-transcranial-magnetic-stimulation-in-humans
#15
Yi Huang, Jui-Cheng Chen, Chun-Ming Chen, Chon-Haw Tsai, Ming-Kuei Lu
Pairing transcutaneous electric nerve stimulation (TENS) and transcranial magnetic stimulation (TMS) with specific stimulus-intervals induces associative motor plasticity at the primary motor cortex (M1). Electroacupuncture (EA) is an established medical technique in the eastern countries. This study investigates whether EA paired with TMS induces distinct M1 motor plasticity. Fifteen healthy, right-handed subjects (aged 23.6 ± 2.0 years, eight women) were studied. Two-hundred and twenty-five pairs of TMS of the left M1 preceded by right EA at acupoint "Neiguan" [Pericardium 6 (PC6), located 2 decimeters proximal from the wrist wrinkle] were respectively applied with the interstimulus interval (ISI) of individual somatosensory evoked potential (SSEP) N20 latency plus 2 ms (N20+2) and minus 5 ms (N20-5) with at least 1-week interval...
2019: Frontiers in Human Neuroscience
https://read.qxmd.com/read/28460580/therapeutic-efficacy-of-the-ginkgo-special-extract-egb761-%C3%A2-within-the-framework-of-the-mitochondrial-cascade-hypothesis-of-alzheimer-s-disease
#16
Walter E Müller, Anne Eckert, Gunter P Eckert, Heidrun Fink, Kristina Friedland, Serge Gauthier, Robert Hoerr, Ralf Ihl, Siegfried Kasper, Hans-Jürgen Möller
OBJECTIVES: The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction as an important common pathomechanism for the whole spectrum of age-associated memory disorders from cognitive symptoms in the elderly over mild cognitive impairment to Alzheimer's dementia. Thus, a drug such as the Ginkgo special extract EGb 761® which improves mitochondrial function should be able to ameliorate cognitive deficits over the whole aging spectrum. METHODS: We review the most relevant publications about effects of EGb 761® on cognition and synaptic deficits in preclinical studies as well as on cognitive deficits in man from aging to dementia...
May 2, 2017: World Journal of Biological Psychiatry
https://read.qxmd.com/read/29383983/the-role-of-the-gut-microbiota-in-schizophrenia-current-and-future-perspectives
#17
REVIEW
Daniela Rodrigues-Amorim, Tania Rivera-Baltanás, Benito Regueiro, Carlos Spuch, María Elena de Las Heras, Raul Vázquez-Noguerol Méndez, Maria Nieto-Araujo, Carolina Barreiro-Villar, Jose Manuel Olivares, Roberto Carlos Agís-Balboa
OBJECTIVES: Schizophrenia is a poorly understood chronic disease. Its pathophysiology is complex, dynamic, and linked to epigenetic mechanisms and microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing to its multidimensional implications: temporal and spatial variability. Microbiota involvement and epigenetic mechanisms are factors that are currently being considered to better understand another dimension of schizophrenia. METHODS: This review summarises and discusses currently available information, focussing on the microbiota, epigenetic mechanisms, technological approaches aimed at performing exhaustive analyses of the microbiota, and psychotherapies, to establish future perspectives...
December 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/26247220/nmda-receptor-antagonists-for-depression-critical-considerations
#18
REVIEW
Gianluca Serafini, Xenia Gonda, Zoltan Rihmer, Maurizio Pompili, Paolo Girardi, Henry A Nasrallah, Mario Amore
BACKGROUND: Research studies suggest that glutamate dysfunction, in particular N-methyl-D-aspartate receptors (NMDARs) abnormalities, may be involved in the pathophysiology of major neuropsychiatric conditions. Increased glutamatergic excitotoxic activity may be found in some brain circuits of patients with major depression. According to several published reports, NMDAR antagonists may exert antidepressant activity, but the molecular changes associated with abnormal glutamatergic neurotransmission remain unclear...
August 2015: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://read.qxmd.com/read/27490835/placebo-controlled-augmentation-trials-of-the-antioxidant-nac-in-schizophrenia-a-review
#19
REVIEW
Alexander T Chen, John T Chibnall, Henry A Nasrallah
BACKGROUND: Several studies have reported that schizophrenia is associated with mitochondrial abnormalities, glutathione deficit, and increased brain oxidative stress (free radicals). N-acetylcysteine (NAC) is a strong antioxidant with potential therapeutic benefit in schizophrenia, according to some reports. We conducted a review of the published controlled studies, with the goal of determining the efficacy profile of NAC as an adjunctive treatment for schizophrenia. METHODS: An online search was conducted for all placebo-controlled, double-blind, randomized clinical trials of NAC in schizophrenia, and a review was conducted...
August 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://read.qxmd.com/read/30699214/a-prenatal-supplement-with-methylfolate-for-the-treatment-and-prevention-of-depression-in-women-trying-to-conceive-and-during-pregnancy
#20
Marlene P Freeman, Gina M Savella, Taylor R Church, Lina Góez-Mogollón, Alexandra Z Sosinsky, Olivia B Noe, Anjali Kaimal, Lee S Cohen
BACKGROUND: Women often seek antidepressant alternatives for major depressive disorder (MDD) in anticipation of or during pregnancy. In this preliminary study, EnBrace HR, a prenatal supplement containing methylfolate, was investigated for depressive relapse prevention and for acute treatment of MDD in women planning pregnancy or during pregnancy. METHODS: This 12-week open-label study included women with histories of MDD who were planning pregnancy or pregnant < 28 weeks...
February 2019: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
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