collection
https://read.qxmd.com/read/37516021/traditional-chinese-medicine-for-the-treatment-of-alzheimer-s-disease-a-focus-on-the-microbiota-gut-brain-axis
#1
REVIEW
Lina Ma, Xuefan Jiang, Qiaoyi Huang, Wenxuan Chen, Huiqin Zhang, Hui Pei, Yu Cao, Huichan Wang, Hao Li
Alzheimer's disease (AD), the most frequent cause of dementia, is a neurodegenerative disorder characterised by a progressive decline in cognitive function that is associated with the formation of amyloid beta plaques and neurofibrillary tangles. Gut microbiota comprises of a complex community of microorganisms residing in the gastrointestinal ecosystem. These microorganisms can participate in gut-brain axis activities, thereby affecting cognitive function and associated behaviours. Increasing evidence has indicated that gut dysbiosis can jeopardise host immune responses and promote inflammation, which may be an initiating factor for the onset and evolution of AD...
July 27, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37088277/chatgpt-outscored-human-candidates-in-a-virtual-objective-structured-clinical-examination-in-obstetrics-and-gynecology
#2
JOURNAL ARTICLE
Sarah W Li, Matthew W Kemp, Susan J S Logan, Pooja Sharma Dimri, Navkaran Singh, Citra N Z Mattar, Pradip Dashraath, Harshaana Ramlal, Aniza P Mahyuddin, Suren Kanayan, Sean W D Carter, Serene P T Thain, Erin L Fee, Sebastian E Illanes, Mahesh A Choolani
BACKGROUND: Natural language processing is a form of artificial intelligence that allows human users to interface with a machine without using complex codes. The ability of natural language processing systems, such as ChatGPT, to successfully engage with healthcare systems requiring fluid reasoning, specialist data interpretation, and empathetic communication in an unfamiliar and evolving environment is poorly studied. This study investigated whether the ChatGPT interface could engage with and complete a mock objective structured clinical examination simulating assessment for membership of the Royal College of Obstetricians and Gynaecologists...
August 2023: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/37398396/novel-compound-inhibits-glycolysis-proteotoxicity-inflammation-and-impairments-in-animal-models-of-alzheimer-s-huntington-s-and-stroke-aging-as-a-consequence-of-glycolysis
#3
Rachel Litke, Kun-Hyung Roh, Yonejung Yoon, Sindhu Vangeti, Irene Ramos-Lopez, Husnu Kaniskan, Jian Jin, Christopher Kellner, Charles Mobbs
Alzheimer's Disease (AD) and other age-related diseases are increasingly among the most devastating strains on public health systems as the population ages, yet few treatments produce clinically significant protection. Although it is widely agreed that proteotoxicity drives impairments in AD and other neurological diseases, many preclinical and case-report studies indicate that increased microglial production of pro-inflammatory cytokines such as TNF-a mediate proteotoxicity in AD and other neurological conditions...
June 13, 2023: bioRxiv
https://read.qxmd.com/read/37393494/synthesis-of-novel-magnetic-quercetin-neuropeptide-nanocomposite-as-a-smart-nano-drug-shuttle-system-investigation-of-its-effect-on-behavior-histopathological-characteristics-and-expression-of-mapt-and-app-genes-in-alzheimer-s-disease-rats
#4
JOURNAL ARTICLE
Kamelia Mobasheri, Mohammad Zaefizadeh, Maryam Ghobeh, Akram Eidi
BACKGROUND: Alzheimer's disease (AD) is the most common type of dementia. The drugs introduced for this disease have many side effects and limitations in use, so the production of a suitable herbal medicine to cure AD patients is essential. OBJECTIVE: The aim of this research is to make a magnetic neuropeptide nano shuttle as a targeted carrier for the transfer of quercetin to the brains of AD model rats. METHODS: In this work, a magnetic quercetin-neuropeptide nanocomposite (MQNPN) was fabricated and administered to the rat's brain by the shuttle drug of the Margatoxin scorpion venom neuropeptide, and will be a prospect for targeted drug delivery in AD...
June 29, 2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/37043625/monitoring-fast-synaptic-transmission-of-neuromodulatory-transmitters-to-define-drug-effects-in-the-brain
#5
JOURNAL ARTICLE
Brooke A Christensen, Erin S Calipari
Catecholaminergic systems are involved in a range of psychiatric disorders and are central mediators of the effects of stimulants on the brain and behavior. Advances in analytical detection methods paired with creative application of these approaches allow for recording noradrenergic and dopaminergic systems in the brain in isolation with subsecond resolution. Pauly et al. ( ACS Chem. Neurosci. 2023, 10.1021/acschemneuro.2c00689) define the distinct and differential mechanisms of methamphetamine enantiomers on dopamine and norepinephrine release, giving critical insights into the pharmacodynamic properties of a stimulant that is both abused and used clinically...
May 3, 2023: ACS Chemical Neuroscience
https://read.qxmd.com/read/37043723/cardiolipin-and-opa1-team-up-for-methamphetamine-induced-locomotor-activity-by-promoting-neuronal-mitochondrial-fusion-in-the-nucleus-accumbens-of-mice
#6
JOURNAL ARTICLE
Liang Wang, Qingfan Wei, Rui Xu, Yaxing Chen, Shu Li, Qian Bu, Ying Zhao, Hongchun Li, Yue Zhao, Linhong Jiang, Yuanyuan Chen, Yanping Dai, Yinglan Zhao, Xiaobo Cen
Mitochondria are highly dynamic organelles with coordinated cycles of fission and fusion occurring continuously to satisfy the energy demands in the complex architecture of neurons. How mitochondria contribute to addicted drug-induced adaptable mitochondrial networks and neuroplasticity remains largely unknown. Through liquid chromatography-mass spectrometry-based lipidomics, we first analyzed the alteration of the mitochondrial lipidome of three mouse brain areas in methamphetamine (METH)-induced locomotor activity and conditioned place preference...
May 3, 2023: ACS Chemical Neuroscience
https://read.qxmd.com/read/37067527/multi-state-model-based-identification-of-cryptic-allosteric-sites-on-human-serotonin-transporter
#7
JOURNAL ARTICLE
Gao Tu, Binbin Xu, Ding Luo, Jin Liu, Zerong Liu, Gang Chen, Weiwei Xue
Serotonin transporter (SERT) plays a fundamental role in taking the synaptic cleft serotonin back to the presynaptic neuron. The discovery of allosteric SERT modulators represents the next-generation medication for psychiatric disorders such as depression. Here, based on the cryo-EM structures of ibogaine in complex with SERT in distinct conformations, the multiple functional structures of the transporter bound to serotonin, including outward-open (OOholo ), outward-occluded (OCholo ), and inward-open (IOholo and IOholo '), were carefully characterized by induced-fit docking Gaussian-accelerated molecular dynamics (IFD-GaMD) simulation and the free-energy landscape analysis...
April 17, 2023: ACS Chemical Neuroscience
https://read.qxmd.com/read/36942075/donepezil-beyond-alzheimer-s-disease-a-narrative-review-of-therapeutic-potentials-of-donepezil-in-different-diseases
#8
REVIEW
Parham Pooladgar, Mehdi Sakhabakhsh, Arsia Taghva, Saeed Soleiman-Meigooni
Donepezil hydrochloride is an acetylcholine esterase inhibitor studied and approved to treat Alzheimer's disease (AD). However, this drug can have positive therapeutic potential in treating different conditions, including various neurodegenerative disorders such as other types of dementia, multiple sclerosis, Parkinson's disease, psychiatric and mood disorders, and even infectious diseases. Hence, this study reviewed the therapeutic potential of this drug in treating Alzheimer's and other diseases by reviewing the articles from databases including Web of Science, Scopus, PubMed, Cochrane, and Science Direct...
December 2022: Iranian Journal of Pharmaceutical Research: IJPR
https://read.qxmd.com/read/36883886/when-and-how-to-use-lithium-augmentation-for-treating-major-depressive-disorder
#9
JOURNAL ARTICLE
Mete Ercis, Aysegul Ozerdem, Balwinder Singh
No abstract text is available yet for this article.
March 8, 2023: Journal of Clinical Psychiatry
https://read.qxmd.com/read/37000522/a-peer-recovery-coach-intervention-for-hospitalized-patients-with-opioid-use-disorder-a-pilot-randomized-controlled-trial
#10
JOURNAL ARTICLE
Joji Suzuki, Bianca Martin, Frank Loguidice, David Smelson, Jane M Liebschutz, Jeffrey L Schnipper, Roger D Weiss
OBJECTIVES: Patients with opioid use disorder (OUD) are increasingly being hospitalized for acute medical illnesses. Despite initiation of medications for OUD (MOUDs), many discontinue treatment after discharge. To evaluate whether a psychosocial intervention can improve MOUD retention after hospitalization, we conducted a pilot randomized controlled trial of a peer recovery coach intervention. METHODS: An existing peer recovery coach intervention was adapted for this trial...
March 31, 2023: Journal of Addiction Medicine
https://read.qxmd.com/read/37009344/xylazine-in-the-opioid-epidemic-a-systematic-review-of-case-reports-and-clinical-implications
#11
REVIEW
Shahana Ayub, Shanli Parnia, Karuna Poddar, Anil K Bachu, Amanda Sullivan, Ali M Khan, Saeed Ahmed, Lakshit Jain
INTRODUCTION AND OBJECTIVES: The opioid overdose epidemic is exacerbated by the emergence of Xylazine as an illicit drug adulterant. Xylazine, a veterinary sedative, can potentiate opioid effects while also causing toxic and potentially fatal side effects. This systematic review aims to assess the impact of Xylazine use and overdoses within the opioid epidemic context. METHOD: A systematic search was conducted following PRISMA guidelines to identify relevant case reports, and case series related to Xylazine use...
March 2023: Curēus
https://read.qxmd.com/read/36769059/tryptophan-and-substance-abuse-mechanisms-and-impact
#12
REVIEW
Majid Davidson, Niloufar Rashidi, Md Kamal Hossain, Ali Raza, Kulmira Nurgali, Vasso Apostolopoulos
Addiction, the continuous misuse of addictive material, causes long-term dysfunction in the neurological system. It substantially affects the control strength of reward, memory, and motivation. Addictive substances (alcohol, marijuana, caffeine, heroin, methamphetamine (METH), and nicotine) are highly active central nervous stimulants. Addiction leads to severe health issues, including cardiovascular diseases, serious infections, and pulmonary/dental diseases. Drug dependence may result in unfavorable cognitive impairments that can continue during abstinence and negatively influence recovery performance...
February 1, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36190973/trial-protocol-of-an-open-label-pilot-study-of-lisdexamfetamine-for-the-treatment-of-acute-methamphetamine-withdrawal
#13
JOURNAL ARTICLE
Liam S Acheson, Nadine Ezard, Nicholas Lintzeris, Adrian Dunlop, Jonathan Brett, Craig Rodgers, Anthony Gill, Michael Christmass, Rebecca McKetin, Michael Farrell, Steve Shoptaw, Krista J Siefried
INTRODUCTION: Methamphetamine (MA) use disorder is an important public health concern. MA withdrawal is often the first step in ceasing or reducing use. There are no evidence-based withdrawal treatments, and no medication is approved for the treatment of MA withdrawal. Lisdexamfetamine (LDX) dimesilate, used in the treatment of attention deficit hyperactivity disorder and binge eating disorder has the potential as an agonist therapy to ameliorate withdrawal symptoms, and improve outcomes for patients...
2022: PloS One
https://read.qxmd.com/read/26102198/cinnamon-and-its-metabolite-sodium-benzoate-attenuate-the-activation-of-p21rac-and-protect-memory-and-learning-in-an-animal-model-of-alzheimer-s-disease
#14
JOURNAL ARTICLE
Khushbu K Modi, Avik Roy, Saurabh Brahmachari, Suresh B Rangasamy, Kalipada Pahan
This study underlines the importance of cinnamon, a commonly used natural spice and flavoring material, and its metabolite sodium benzoate (NaB) in attenuating oxidative stress and protecting memory and learning in an animal model of Alzheimer's disease (AD). NaB, but not sodium formate, was found to inhibit LPS-induced production of reactive oxygen species (ROS) in mouse microglial cells. Similarly, NaB also inhibited fibrillar amyloid beta (Aβ)- and 1-methyl-4-phenylpyridinium(+)-induced microglial production of ROS...
2015: PloS One
https://read.qxmd.com/read/36872775/unlocking-modifiable-risk-factors-for-alzheimer-s-disease-does-the-oral-microbiome-hold-some-of-the-keys
#15
REVIEW
Amy Loughman, Christina J Adler, Helen Macpherson
Advancing age is recognized as the primary risk factor for Alzheimer's disease (AD); however approximately one third of dementia cases are attributable to modifiable risk factors such as hypertension, diabetes, smoking, and obesity. Recent research also implicates oral health and the oral microbiome in AD risk and pathophysiology. The oral microbiome contributes to the cerebrovascular and neurodegenerative pathology of AD via the inflammatory, vascular, neurotoxic, and oxidative stress pathways of known modifiable risk factors...
2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/36865040/protective-effect-of-hot-peppers-against-amyloid-%C3%AE-peptide-and-brain-injury-in-alcl-3-induced-alzheimer-s-disease-in-rats
#16
JOURNAL ARTICLE
Omar M E Abdel-Salam, Marwa El-Sayed El-Shamarka, Eman R Youness, Nermeen Shaffie
OBJECTIVES: This study investigated the therapeutic effect of red hot pepper ( Capsicum annuum) methanolic extract in induced Alzheimer's disease using AlCl3 in male rats. MATERIALS AND METHODS: Rats were injected with AlCl3 intraperitoneally (IP) daily for two months. Starting from the 2nd month of AlCl3 , rats received, in addition, IP treatments with Capsicum extract (25 and 50 mg/kg) or saline. Other groups received only saline or Capsicum extract at 50 mg/kg for two months...
March 2023: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/36185696/the-antidepressant-effects-and-serum-metabonomics-of-bifid-triple-viable-capsule-in-a-rat-model-of-chronic-unpredictable-mild-stress
#17
JOURNAL ARTICLE
Qinpeng Bu, Jingkai Zhang, Xiang Guo, Yifei Feng, Huan Yan, Weimin Cheng, Zhitao Feng, Meiqun Cao
BACKGROUND: Probiotics have shown potential antidepressant effects. This study evaluated the effect and probable mechanisms of bifid triple viable capsules (BTVCs) on a rat model of chronic unpredictable mild stress (CUMS). MATERIALS AND METHODS: Rats were randomly divided into Normal, CUMS model, fluoxetine hydrochloride (FLX), BTVCs, and FLX+BTVCs groups. Depressive-like behaviours, pathological changes in the hippocampus, changes in serum metabolites and potential biomarkers, and metabolic pathways were detected via behavioural tests, haematoxylin-eosin staining, nissl staining, non-targetted metabolomics, and ingenuity pathway analysis (IPA)...
2022: Frontiers in Nutrition
https://read.qxmd.com/read/36736919/gut-brain-axis-through-the-lens-of-gut-microbiota-and-their-relationships-with-alzheimer-s-disease-pathology-review-and-recommendations
#18
JOURNAL ARTICLE
Krishaa L, Ted Kheng Siang Ng, Hai Ning Wee, Jianhong Ching
Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Growing evidence suggests that the gut microbiome (GM) plays a pivotal role in the pathogenesis of AD through the microbiota-gut-brain axis (MGB). Alterations in GM composition and diversity have been observed in both animal models and in human patients with AD. GM dysbiosis has been implicated in increased intestinal permeability, blood-brain barrier (BBB) impairment, neuroinflammation and the development of hallmarks of AD...
April 2023: Mechanisms of Ageing and Development
https://read.qxmd.com/read/36255671/cells-of-the-central-nervous-system-an-overview-of-their-structure-and-function
#19
JOURNAL ARTICLE
John W Bigbee
The central nervous system is the last major organ system in the vertebrate body to yield its cellular structure, due to the complexity of its cells and their interactions. The fundamental unit of the nervous system is the neuron, which forms complex circuits that receive and integrate information and generate adaptive responses. Each neuron is composed of an input domain consisting of multiple dendrites along with the cell body, which is also responsible for the majority of macromolecule synthesis for the cell...
2023: Advances in Neurobiology
https://read.qxmd.com/read/36401591/clinical-management-of-psychostimulant-withdrawal-review-of-the-evidence
#20
REVIEW
Michael J Li, Steven J Shoptaw
It is estimated that a majority of people who use psychostimulants, particularly methamphetamine (MA) and cocaine, experience withdrawal upon abstinence from sustained use. This review of clinical research reports the evidence regarding biomedical and behavioral treatments for psychostimulant withdrawal symptoms. It provides a framework for clinicians and scientists to increase impact on attenuating MA and cocaine withdrawal during initial and sustained abstinence. Articles reviewed included reports of controlled clinical trials (randomized or non-randomized) reporting at least one withdrawal symptom among the outcomes or specifically studying patients in withdrawal...
April 2023: Addiction
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