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Naturopathic Medicine

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65 papers 1000+ followers Collection of RCTs and other papers + editorials
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://read.qxmd.com/read/30404216/benzylisoquinoline-alkaloids-biosynthesis-in-sacred-lotus
#1
REVIEW
Ivette M Menéndez-Perdomo, Peter J Facchini
Sacred lotus ( Nelumbo nucifera Gaertn.) is an ancient aquatic plant used throughout Asia for its nutritional and medicinal properties. Benzylisoquinoline alkaloids (BIAs), mostly within the aporphine and bisbenzylisoquinoline structural categories, are among the main bioactive constituents in the plant. The alkaloids of sacred lotus exhibit promising anti-cancer, anti-arrhythmic, anti-HIV, and anti-malarial properties. Despite their pharmacological significance, BIA metabolism in this non-model plant has not been extensively investigated...
November 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/20645801/anabolic-and-androgenic-activities-of-bulbine-natalensis-stem-in-male-wistar-rats
#2
COMPARATIVE STUDY
Musa T Yakubu, Anthony J Afolayan
Aqueous extract of Bulbine natalensis Baker (Asphodelaceae) stem at 25, 50 and 100 mg/kg body weight was investigated for anabolic and androgenic effects in male Wistar rats. Sixty male rats were grouped into four (A-D) consisting of 15 each. Group A (control) was orally treated with 0.5 mL of distilled water for 14 days while groups B, C and D were treated like the control except they received 0.5 mL containing 25, 50, and 100 mg/kg body weight of the extract respectively. All the doses of the extract increased (P <0...
May 2010: Pharmaceutical Biology
https://read.qxmd.com/read/30809139/rebound-or-entrainment-the-influence-of-alternating-current-stimulation-on-individual-alpha
#3
Linus Haberbosch, Sein Schmidt, Andreas Jooss, Arvid Köhn, Leonard Kozarzewski, Maria Rönnefarth, Michael Scholz, Stephan A Brandt
Alternating current stimulation (ACS) is an established means to manipulate intrinsic cortical oscillations. While working towards clinical impact, ACS mechanisms of action remain unclear. For ACS's well-documented influence on occipital alpha, hypotheses include neuronal entrainment as well as rebound phenomena. As a retinal origin is also discussed, we employed a novel form of ACS with the advantage that it specifically targets occipital alpha-oscillations via retinofugal pathways retinofugal ACS (rACS). We aimed to confirm alpha-enhancement outlasting the duration of stimulation with 10 Hz rACS...
2019: Frontiers in Human Neuroscience
https://read.qxmd.com/read/30809140/paired-associative-electroacupuncture-and-transcranial-magnetic-stimulation-in-humans
#4
Yi Huang, Jui-Cheng Chen, Chun-Ming Chen, Chon-Haw Tsai, Ming-Kuei Lu
Pairing transcutaneous electric nerve stimulation (TENS) and transcranial magnetic stimulation (TMS) with specific stimulus-intervals induces associative motor plasticity at the primary motor cortex (M1). Electroacupuncture (EA) is an established medical technique in the eastern countries. This study investigates whether EA paired with TMS induces distinct M1 motor plasticity. Fifteen healthy, right-handed subjects (aged 23.6 ± 2.0 years, eight women) were studied. Two-hundred and twenty-five pairs of TMS of the left M1 preceded by right EA at acupoint "Neiguan" [Pericardium 6 (PC6), located 2 decimeters proximal from the wrist wrinkle] were respectively applied with the interstimulus interval (ISI) of individual somatosensory evoked potential (SSEP) N20 latency plus 2 ms (N20+2) and minus 5 ms (N20-5) with at least 1-week interval...
2019: Frontiers in Human Neuroscience
https://read.qxmd.com/read/28460580/therapeutic-efficacy-of-the-ginkgo-special-extract-egb761-%C3%A2-within-the-framework-of-the-mitochondrial-cascade-hypothesis-of-alzheimer-s-disease
#5
Walter E Müller, Anne Eckert, Gunter P Eckert, Heidrun Fink, Kristina Friedland, Serge Gauthier, Robert Hoerr, Ralf Ihl, Siegfried Kasper, Hans-Jürgen Möller
OBJECTIVES: The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction as an important common pathomechanism for the whole spectrum of age-associated memory disorders from cognitive symptoms in the elderly over mild cognitive impairment to Alzheimer's dementia. Thus, a drug such as the Ginkgo special extract EGb 761® which improves mitochondrial function should be able to ameliorate cognitive deficits over the whole aging spectrum. METHODS: We review the most relevant publications about effects of EGb 761® on cognition and synaptic deficits in preclinical studies as well as on cognitive deficits in man from aging to dementia...
May 2, 2017: World Journal of Biological Psychiatry
https://read.qxmd.com/read/29383983/the-role-of-the-gut-microbiota-in-schizophrenia-current-and-future-perspectives
#6
Daniela Rodrigues-Amorim, Tania Rivera-Baltanás, Benito Regueiro, Carlos Spuch, María Elena de Las Heras, Raul Vázquez-Noguerol Méndez, Maria Nieto-Araujo, Carolina Barreiro-Villar, Jose Manuel Olivares, Roberto Carlos Agís-Balboa
OBJECTIVES: Schizophrenia is a poorly understood chronic disease. Its pathophysiology is complex, dynamic, and linked to epigenetic mechanisms and microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing to its multidimensional implications: temporal and spatial variability. Microbiota involvement and epigenetic mechanisms are factors that are currently being considered to better understand another dimension of schizophrenia. METHODS: This review summarises and discusses currently available information, focussing on the microbiota, epigenetic mechanisms, technological approaches aimed at performing exhaustive analyses of the microbiota, and psychotherapies, to establish future perspectives...
December 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/26247220/nmda-receptor-antagonists-for-depression-critical-considerations
#7
REVIEW
Gianluca Serafini, Xenia Gonda, Zoltan Rihmer, Maurizio Pompili, Paolo Girardi, Henry A Nasrallah, Mario Amore
BACKGROUND: Research studies suggest that glutamate dysfunction, in particular N-methyl-D-aspartate receptors (NMDARs) abnormalities, may be involved in the pathophysiology of major neuropsychiatric conditions. Increased glutamatergic excitotoxic activity may be found in some brain circuits of patients with major depression. According to several published reports, NMDAR antagonists may exert antidepressant activity, but the molecular changes associated with abnormal glutamatergic neurotransmission remain unclear...
August 2015: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://read.qxmd.com/read/27490835/placebo-controlled-augmentation-trials-of-the-antioxidant-nac-in-schizophrenia-a-review
#8
REVIEW
Alexander T Chen, John T Chibnall, Henry A Nasrallah
BACKGROUND: Several studies have reported that schizophrenia is associated with mitochondrial abnormalities, glutathione deficit, and increased brain oxidative stress (free radicals). N-acetylcysteine (NAC) is a strong antioxidant with potential therapeutic benefit in schizophrenia, according to some reports. We conducted a review of the published controlled studies, with the goal of determining the efficacy profile of NAC as an adjunctive treatment for schizophrenia. METHODS: An online search was conducted for all placebo-controlled, double-blind, randomized clinical trials of NAC in schizophrenia, and a review was conducted...
August 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://read.qxmd.com/read/30699214/a-prenatal-supplement-with-methylfolate-for-the-treatment-and-prevention-of-depression-in-women-trying-to-conceive-and-during-pregnancy
#9
Marlene P Freeman, Gina M Savella, Taylor R Church, Lina Góez-Mogollón, Alexandra Z Sosinsky, Olivia B Noe, Anjali Kaimal, Lee S Cohen
BACKGROUND: Women often seek antidepressant alternatives for major depressive disorder (MDD) in anticipation of or during pregnancy. In this preliminary study, EnBrace HR, a prenatal supplement containing methylfolate, was investigated for depressive relapse prevention and for acute treatment of MDD in women planning pregnancy or during pregnancy. METHODS: This 12-week open-label study included women with histories of MDD who were planning pregnancy or pregnant < 28 weeks...
February 2019: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://read.qxmd.com/read/20624868/vitamin-d-in-adult-health-and-disease-a-review-and-guideline-statement-from-osteoporosis-canada
#10
REVIEW
David A Hanley, Ann Cranney, Glenville Jones, Susan J Whiting, William D Leslie, David E C Cole, Stephanie A Atkinson, Robert G Josse, Sidney Feldman, Gregory A Kline, Cheryl Rosen
No abstract text is available yet for this article.
September 7, 2010: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://read.qxmd.com/read/30773866/-brain-regions-responding-to-acupuncture-stimulation-of-zusanli-st36-in-healthy-subjects-analyzed-on-the-basis-of-spontaneous-brain-activity
#11
An-Feng Xiang, Hui Liu, Sheng Liu, Xue-Yong Shen
OBJECTIVE: To determine the attributes of responses of the higher nerve center to acupuncture stimulation of Zusanli (ST36) on the basis of spontaneous brain activity, so as to explore the synchronization level of different brain rejoins after acupuncture. METHODS: All studies using fMRI to investigate the effect of acupuncture stimulation of ST36 and/or other acupoints on the human brain (at least 10 healthy subjects or patients in one group) published in journals from January of 1995 to January of 2018 were searched from databases of CNKI and PubMed by using keywords of acupuncture, electroacupuncture, and resting-state functional magnetic resonance images (rs-fMRI) or regional homogeneity (ReHo)...
January 25, 2019: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/30547302/the-role-of-vitamins-and-minerals-in-hair-loss-a-review
#12
REVIEW
Hind M Almohanna, Azhar A Ahmed, John P Tsatalis, Antonella Tosti
People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing...
December 13, 2018: Dermatology and Therapy
https://read.qxmd.com/read/30762770/efficacy-and-mechanism-of-acupuncture-for-ischemic-poststroke-depression-study-protocol-for-a-multicenter-single-blinded-randomized-sham-controlled-trial
#13
Hai Lu, Menghan Li, Bo Zhang, Xuesong Ren, Lina Meng, Weijing Bai, Li Wang, Zhenzhen Wang, Shaojie Ding, Yuanyuan Gan, Zhilong Zhang, Peifang Li, Linpeng Wang, Zhihong Meng, Hong Zhao, Fei Wang, Chunhong Zhang
INTRODUCTION: Poststroke depression is a serious and common complication of stroke, especially the ischemic poststroke depression. Antidepressants are used in poststroke depression, and acupuncture may be an alternative approach. However, the efficacy and mechanism of acupuncture for poststroke depression has not been confirmed. METHODS/DESIGN: This is a multicenter, central-randomized, single-blind, sham-controlled clinical trial. We will allocate 208 subjects aged between 40 and 80 years old, diagnosed with initial poststroke depression (PSD) within 6 months to 2 groups randomly in a ratio of 1:1...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30545069/guidelines-for-the-treatment-of-ptsd-using-clinical-eft-emotional-freedom-techniques
#14
REVIEW
Dawson Church, Peta Stapleton, Phil Mollon, David Feinstein, Elizabeth Boath, David Mackay, Rebecca Sims
Clinical EFT (Emotional Freedom Techniques) is an evidence-based method that combines acupressure with elements drawn from cognitive and exposure therapies. The approach has been validated in more than 100 clinical trials. Its efficacy for post-traumatic stress disorder (PTSD) has been investigated in a variety of demographic groups including war veterans, victims of sexual violence, the spouses of PTSD sufferers, motor accident survivors, prisoners, hospital patients, adolescents, and survivors of natural and human-caused disasters...
December 12, 2018: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/30683245/effects-of-auricular-acupressure-on-pain-and-disability-in-adults-with-chronic-neck-pain
#15
Shinae Lee, Hyojung Park
AIM: The aim of this study was to examine the effect of auricular acupressure (AA) on pain, pain threshold (PT), disability, and cervical range of motion in adults with chronic neck pain. BACKGROUND: About 30-50% of the world's population suffers from chronic neck pain, and the cost of treatment is increasing. MATERIALS AND METHODS: This single-blind, randomized sham-controlled study was conducted on 48 adults with chronic neck pain in South Korea...
February 2019: Applied Nursing Research: ANR
https://read.qxmd.com/read/30687806/impact-of-self-acupressure-on-co-occurring-symptoms-in-cancer-survivors
#16
Suzanna Maria Zick, Ananda Sen, Afton Luevano Hassett, Andrew Schrepf, Gwen Karilyn Wyatt, Susan Lynn Murphy, John Todd Arnedt, Richard Edmund Harris
Background: Cancer survivors with fatigue often experience depressive symptoms, anxiety, and pain. Previously, we reported that self-acupressure improved fatigue; however, its impact on other co-occurring symptoms and their involvement in treatment action has not been explored. Methods: Changes in depressive symptoms, anxiety, and pain were examined prior to and following two formulas of self-acupressure and usual care using linear mixed models in 288 women from a previously reported clinical trial...
November 2018: JNCI cancer spectrum
https://read.qxmd.com/read/30400332/vitamin-d-nutrient-hormone-and-immunomodulator
#17
REVIEW
Francesca Sassi, Cristina Tamone, Patrizia D'Amelio
The classical functions of vitamin D are to regulate calcium-phosphorus homeostasis and control bone metabolism. However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. These observations, together with experimental studies, suggest a critical role for vitamin D in the modulation of immune function. This leads to the hypothesis of a disease-specific alteration of vitamin D metabolism and reinforces the role of vitamin D in maintaining a healthy immune system...
November 3, 2018: Nutrients
https://read.qxmd.com/read/30430640/an-integrative-review-of-acupressure-interventions-for-older-people-a-focus-on-sleep-quality-depression-anxiety-and-agitation
#18
REVIEW
Nant Thin Thin Hmwe, Graeme Browne, Lyndall Mollart, Viv Allanson, Sally Wai-Chi Chan
OBJECTIVES: This integrative review aimed to synthesize studies that investigated the effects of acupressure on sleep quality, depression, anxiety, and agitation in older people, and to describe the acupressure procedures and techniques applied in the included studies. METHODS: A literature search was conducted using electronic databases including CINAHL, Cochrane Library, EMBASE, and MEDLINE. The inclusion criteria for the review were studies examining the effect of acupressure in older people aged 60 years and above, measured the outcomes for sleep quality, depression, anxiety or agitation, applied body acupressure, and published in English language...
March 2019: International Journal of Geriatric Psychiatry
https://read.qxmd.com/read/27451854/auricular-acupuncture-for-substance-use-a-randomized-controlled-trial-of-effects-on-anxiety-sleep-drug-use-and-use-of-addiction-treatment-services
#19
RANDOMIZED CONTROLLED TRIAL
Rickard Ahlberg, Kurt Skårberg, Ole Brus, Lars Kjellin
BACKGROUND: A common alternative treatment for substance abuse is auricular acupuncture. The aim of the study was to evaluate the short and long-term effect of auricular acupuncture on anxiety, sleep, drug use and addiction treatment utilization in adults with substance abuse. METHOD: Of the patients included, 280 adults with substance abuse and psychiatric comorbidity, 80 were randomly assigned to auricular acupuncture according to the NADA protocol, 80 to auricular acupuncture according to a local protocol (LP), and 120 to relaxation (controls)...
July 25, 2016: Substance Abuse Treatment, Prevention, and Policy
https://read.qxmd.com/read/29414848/nada-protocol-for-behavioral-health-putting-tools-in-the-hands-of-behavioral-health-providers-the-case-for-auricular-detoxification-specialists
#20
Elizabeth B Stuyt, Claudia A Voyles, Sara Bursac
Background: The National Acupuncture Detoxification Association (NADA) protocol, a simple standardized auricular treatment has the potential to provide vast public health relief on issues currently challenging our world. This includes but is not limited to addiction, such as the opioid epidemic, but also encompasses mental health, trauma, PTSD, chronic stress, and the symptoms associated with these conditions. Simple accessible tools that improve outcomes can make profound differences. We assert that the NADA protocol can have greatest impact when broadly applied by behavioral health professionals, Auricular Detoxification Specialists (ADSes)...
February 7, 2018: Medicines (Basel, Switzerland)
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