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11 papers 25 to 100 followers
By Paul Ross ICUnurses
Philippe Morimont, Andriy Batchinsky, Bernard Lambermont
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at Further information about the Annual Update in Intensive Care and Emergency Medicine is available from
March 16, 2015: Critical Care: the Official Journal of the Critical Care Forum
Alain Combes, Marco Ranieri
No abstract text is available yet for this article.
May 2015: Intensive Care Medicine
Olinto Linares-Perdomo, Thomas D East, Roy Brower, Alan H Morris
BACKGROUND: Recent recommendations for lung protective mechanical ventilation include a tidal volume target of 6 mL/kg predicted body weight (PBW). Different PBW equations might introduce important differences in tidal volumes delivered to research subjects and patients. METHODS: PBW equations use height, age, and sex as input variables. We compared National Institutes of Health (NIH) ARDS Network (ARDSNet), actuarial table (ACTUARIAL), and Stewart (STEWART) PBW equations used in clinical trials, across physiologic ranges for age and height...
July 2015: Chest
Sangeeta Mehta, Deborah J Cook, Yoanna Skrobik, John Muscedere, Claudio M Martin, Thomas E Stewart, Lisa D Burry, Qi Zhou, Maureen Meade
BACKGROUND: The Lung Open Ventilation Study (LOV Study) compared a low tidal volume strategy with an experimental strategy combining low tidal volume, lung recruitment maneuvers, and higher plateau and positive end-expiratory pressures (PEEP) in adults with acute respiratory distress syndrome (ARDS). Herein, we compared sedative, opioid, and neuromuscular blocker (NMB) use among patients managed with the intervention and control strategies and clinicians' assessment of comfort in both groups...
2014: Annals of Intensive Care
Ary Serpa Neto, Fabienne D Simonis, Marcus J Schultz
PURPOSE OF REVIEW: There is convincing evidence for benefit from lung-protective mechanical ventilation with lower tidal volumes in patients with the acute respiratory distress syndrome (ARDS). It is uncertain whether this strategy benefits critically ill patients without ARDS also. The present article summarizes the background and clinical evidence for ventilator settings that have the potential to protect against ventilator-induced lung injury. RECENT FINDINGS: There has been a paradigm shift from treating ARDS to preventing ARDS...
February 2015: Current Opinion in Critical Care
Sami Hraiech, Takeshi Yoshida, Laurent Papazian
PURPOSE OF REVIEW: Acute respiratory distress syndrome (ARDS) is still associated with a high mortality. The best way to ensure mechanical ventilation in ARDS patients is still debated, recent data arguing for a muscle paralysis and a controlled ventilation whereas other elements being in favor of a preserved spontaneous breathing. The purpose of this review is to discuss the benefits and the disadvantages of both strategies. RECENT FINDINGS: Randomized controlled trials have brought the evidence that at the acute phase of ARDS, a 48-h administration of cisatracurium is associated with a decrease in mortality for the most severe hypoxemic patients...
February 2015: Current Opinion in Critical Care
Sangeeta Mehta, Deborah Cook, John W Devlin, Yoanna Skrobik, Maureen Meade, Dean Fergusson, Margaret Herridge, Marilyn Steinberg, John Granton, Niall Ferguson, Maged Tanios, Peter Dodek, Robert Fowler, Karen Burns, Michael Jacka, Kendiss Olafson, Ranjeeta Mallick, Steven Reynolds, Sean Keenan, Lisa Burry
OBJECTIVE: Delirium is common during critical illness and associated with adverse outcomes. We compared characteristics and outcomes of delirious and nondelirious patients enrolled in a multicenter trial comparing protocolized sedation with protocolized sedation plus daily sedation interruption. DESIGN: Randomized trial. SETTING: Sixteen North American medical and surgical ICUs. PATIENTS: Four hundred thirty critically ill, mechanically ventilated adults...
March 2015: Critical Care Medicine
Miquel Ferrer, Antoni Torres
PURPOSE OF REVIEW: This article reviews the use of noninvasive ventilation (NIV) in patients with acute respiratory failure (ARF), with a critical review of the most recent literature in this setting. RECENT FINDINGS: The efficacy of NIV is variable depending on the cause of the episode of ARF. In community-acquired pneumonia, NIV is often associated with poor response, with better response in patients with preexisting cardiac or respiratory disease. In patients with pandemic influenza H1N1 and severe ARF, NIV has been associated with high failure rates but relatively favorable mortality...
February 2015: Current Opinion in Critical Care
Dale M Needham, Ting Yang, Victor D Dinglas, Pedro A Mendez-Tellez, Carl Shanholtz, Jonathan E Sevransky, Roy G Brower, Peter J Pronovost, Elizabeth Colantuoni
RATIONALE: Reducing tidal volume decreases mortality in acute respiratory distress syndrome (ARDS). However, the effect of the timing of low tidal volume ventilation is not well understood. OBJECTIVES: To evaluate the association of intensive care unit (ICU) mortality with initial tidal volume and with tidal volume change over time. METHODS: Multivariable, time-varying Cox regression analysis of a multisite, prospective study of 482 patients with ARDS with 11,558 twice-daily tidal volume assessments (evaluated in milliliter per kilogram of predicted body weight [PBW]) and daily assessment of other mortality predictors...
January 15, 2015: American Journal of Respiratory and Critical Care Medicine
Jesús Villar, Rosa L Fernández, Alfonso Ambrós, Laura Parra, Jesús Blanco, Ana M Domínguez-Berrot, José M Gutiérrez, Lluís Blanch, José M Añón, Carmen Martín, Francisca Prieto, Javier Collado, Lina Pérez-Méndez, Robert M Kacmarek
OBJECTIVE: Current in-hospital mortality of the acute respiratory distress syndrome (ARDS) is above 40%. ARDS outcome depends on the lung injury severity within the first 24 hours of ARDS onset. We investigated whether two widely accepted cutoff values of PaO2/FIO2 and positive end-expiratory pressure (PEEP) would identify subsets of patients with ARDS for predicting outcome and guiding therapy. DESIGN: A 16-month (September 2008 to January 2010) prospective, multicenter, observational study...
February 2015: Critical Care Medicine
Fernando Frutos-Vivar, Andrés Esteban
Withdrawal from mechanical ventilation (or weaning) is one of the most common procedures in intensive care units. Almost 20 years ago, we published one of the seminal papers on weaning in which we showed that the best method for withdrawal from mechanical ventilation in difficult-to-wean patients was a once-daily spontaneous breathing trial with a T-piece. Progress has not stood still, and in the intervening years up to the present several other studies, by our group and others, have shaped weaning into an evidence-based technique...
October 2014: Intensive Care Medicine
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