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By Rosa Elva Vela Pediatric Rheumatology specialist. I Love life .
Natalia Sherina, Hulda S Hreggvidsdottir, Camilla Bengtsson, Monika Hansson, Lena Israelsson, Lars Alfredsson, Karin Lundberg
BACKGROUND: Infection by common viruses has long been discussed in the aetiology of a number of autoimmune diseases, including rheumatoid arthritis (RA). However, studies investigating this hypothesis in RA show conflicting results. These studies often lack well-matched control populations, and many do not include data on autoantibodies, genetic risk factors and other environmental factors, which are known to contribute to disease only in subgroups of patients. In the present study, we have therefore examined the role of Epstein-Barr virus (EBV), cytomegalovirus (CMV) and parvovirus B19 (B19) in RA aetiology, by analysing anti-viral antibodies in relation to anti-citrullinated protein antibodies (ACPA), smoking, HLA-DRB1 shared epitope (SE) alleles, and clinical parameters, in both RA patients and matched controls...
September 30, 2017: Arthritis Research & Therapy
A B Orandi, K W Baszis, V R Dharnidharka, A M Huber, M F Hoeltzel
BACKGROUND: There is no standardized approach to the management of JDM-associated calcinosis and its phenotypes. Current knowledge of treatment outcomes is confined to small series and case reports. We describe physician perspectives toward diagnostic approach, classification and treatment directly targeting calcinosis, independent of overall JDM therapy. METHODS: An electronic survey of 22 questions was organized into sections regarding individual practices of assessment, classification and treatment of calcinosis, including perceived successes of therapies...
September 21, 2017: Pediatric Rheumatology Online Journal
Susan Kim, Philip Kahn, Angela B Robinson, Bianca Lang, Andrew Shulman, Edward J Oberle, Kenneth Schikler, Megan Lea Curran, Lilliana Barillas-Arias, Charles H Spencer, Lisa G Rider, Adam M Huber
BACKGROUND: Juvenile dermatomyositis (JDM) is the most common form of the idiopathic inflammatory myopathies in children. A subset of children have the rash of JDM without significant weakness, and the optimal treatments for these children are unknown. The goal of this study was to describe the development of consensus clinical treatment plans (CTPs) for children with JDM who have active skin rashes, without significant muscle involvement, referred to as skin predominant JDM in this manuscript...
January 11, 2017: Pediatric Rheumatology Online Journal
T Caballero, M L Baeza, R Cabañas, A Campos, S Cimbollek, C Gómez-Traseira, T González-Quevedo, M Guilarte, G J Jurado-Palomo, J I Larco, M C López-Serrano, M López-Trascasa, C Marcos, J M Muñoz-Caro, M Pedrosa, N Prior, M Rubio, A Sala-Cunill
BACKGROUND: There are no Spanish guidelines or consensus statement on bradykinin-induced angioedema. AIM: To review the pathophysiology, genetics, and clinical symptoms of the different types of bradykinin-induced angioedema and to draft a consensus statement in light of currently available scientific evidence and the experience of experts. This statement will serve as a guideline to health professionals. METHODS: The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema (SGBA), a working group of the Spanish Society of Allergology and Clinical Immunology...
2011: Journal of Investigational Allergology & Clinical Immunology
M C Dalakas
The inflammatory muscle diseases dermatomyositis, polymyositis and inclusion body myositis are of unknown cause, but immune mechanisms are strongly implicated. Progress in the past two years has led to an improved understanding of the main molecular events involved in the immunological synapse between muscle and autoinvasive T cells. In particular, we now have a better understanding of TCR gene rearrangement in endomysial T cells, regulation of MHC expression, activity of co-stimulatory molecules, and the signalling cascades activated by cytokines, chemokines and metalloproteinases...
June 2001: Current Opinion in Pharmacology
Marinos C Dalakas
New England Journal of Medicine, Volume 372, Issue 18, Page 1734-1747, April 2015.
April 30, 2015: New England Journal of Medicine
Lionel Carbillon, Eric Lachassinne, Arsene Mekinian
No abstract text is available yet for this article.
June 2015: JAMA Pediatrics
Sheila T Angeles-Han, Courtney McCracken, Steven Yeh, Kirsten Jenkins, Daneka Stryker, Kelly Rouster-Stevens, Larry B Vogler, Scott R Lambert, Carolyn Drews-Botsch, Sampath Prahalad
BACKGROUND: Juvenile idiopathic arthritis-associated uveitis (JIA-U) can lead to poor visual outcomes and impact a child's quality of life (QOL) and function. Our aim is to identify risk markers of JIA-U and examine differences in the QOL of children with JIA and JIA-U. METHODS: Rheumatology and ophthalmology record reviews and questionnaires were completed every 4-6 months on 287 children with JIA. We collected arthritis, uveitis, and QOL data. We examined data through last study visit...
2015: Pediatric Rheumatology Online Journal
Christian K Schneider
No abstract text is available yet for this article.
March 2013: Annals of the Rheumatic Diseases
Emilio B Gonzalez
Gouty arthritis is an inflammatory condition associated with debilitating clinical symptoms, functional impairments, and a substantial impact on quality of life. This condition is initially triggered by the deposition of monosodium urate crystals into the joint space. This causes an inflammatory cascade resulting in the secretion of several proinflammatory cytokines and neutrophil recruitment into the joint. While generally effective, currently available agents are associated with a number of adverse events and contraindications that complicate their use...
January 2012: Clinical Rheumatology
Jelena Vojinovic, Rolando Cimaz
Vitamin D, upon its discovery one century ago, was classified as a vitamin. This classification still greatly affects our perception about its biological role. 1,25(OH)2D (now known as the D hormone) is a pleiotropic steroid hormone that has multiple biologic effects. It is integral to the regulation of calcium homeostasis and bone turnover as well as having anti-proliferative, pro-differentiation, anti-bacterial, immunomodulatory and anti-inflammatory properties within the body in various cells and tissues...
May 29, 2015: Pediatric Rheumatology Online Journal
H J Nieminen, T Ylitalo, S Karhula, J-P Suuronen, S Kauppinen, R Serimaa, E Hæggström, K P H Pritzker, M Valkealahti, P Lehenkari, M Finnilä, S Saarakkala
OBJECTIVE: Collagen distribution within articular cartilage (AC) is typically evaluated from histological sections, e.g., using collagen staining and light microscopy (LM). Unfortunately, all techniques based on histological sections are time-consuming, destructive, and without extraordinary effort, limited to two dimensions. This study investigates whether phosphotungstic acid (PTA) and phosphomolybdic acid (PMA), two collagen-specific markers and X-ray absorbers, could (1) produce contrast for AC X-ray imaging or (2) be used to detect collagen distribution within AC...
September 2015: Osteoarthritis and Cartilage
Reha M Toydemir, Michael J Bamshad
Sheldon-Hall syndrome (SHS) is a rare multiple congenital contracture syndrome characterized by contractures of the distal joints of the limbs, triangular face, downslanting palpebral fissures, small mouth, and high arched palate. Epidemiological data for the prevalence of SHS are not available, but less than 100 cases have been reported in the literature. Other common clinical features of SHS include prominent nasolabial folds, high arched palate, attached earlobes, mild cervical webbing, short stature, severe camptodactyly, ulnar deviation, and vertical talus and/or talipes equinovarus...
March 23, 2009: Orphanet Journal of Rare Diseases
Benjamin Terrier, Agnès Dechartres, Charlotte Girard, Stéphane Jouneau, Jean-Emmanuel Kahn, Robin Dhote, Estibaliz Lazaro, Jean Cabane, Thomas Papo, Nicolas Schleinitz, Pascal Cohen, Edouard Begon, Pauline Belenotti, Dominique Chauveau, Elisabeth Diot, Thierry Généreau, Mohamed Hamidou, Gilles Hayem, Guillaume Le Guenno, Véronique Le Guern, Marc Michel, Guillaume Moulis, Xavier Puéchal, Sophie Rivière, Maxime Samson, François Gonin, Claire Le Jeunne, Pascal Corlieu, Luc Mouthon, Loic Guillevin
OBJECTIVES: Tracheobronchial stenosis (TBS) is noted in 12-23% of patients with granulomatosis with polyangiitis (GPA), and includes subglottic stenosis and bronchial stenosis. We aimed to analyse the endoscopic management of TBS in GPA and to identify factors associated with the efficacy of endoscopic interventions. METHODS: We conducted a French nationwide retrospective study that included 47 patients with GPA-related TBS. RESULTS: Compared with patients without TBS, those with TBS were younger, more frequently female and had less frequent kidney, ocular and gastrointestinal involvement and mononeuritis multiplex...
October 2015: Rheumatology
Michelle L Burbage, Meredith B Mason, Laura A Nabors, Jessica C Kichler
BACKGROUND: The current study evaluated the support and education families with a child who has Juvenile Idiopathic Arthritis (JIA) received during a weekend family retreat. METHODS: Thirty-one parents completed surveys at the end of the retreat session. Survey questions examined parent's perceptions of the family retreat experience including what they learned and how beneficial it was to their family. RESULTS: Results indicated that the family retreat was beneficial to both the children with JIA and their siblings...
2015: Pediatric Rheumatology Online Journal
A Lallas, Z Apalla, I Lefaki, E Sotiriou, E Lazaridou, D Ioannides, D Tiodorovic-Zivkovic, T Sidiropoulos, D Konstantinou, V Di Lernia, G Argenziano, I Zalaudek
BACKGROUND: Dermoscopy is useful in evaluating skin tumours, but its applicability also extends into the field of inflammatory skin disorders. Discoid lupus erythematosus (DLE) represents the most common subtype of cutaneous lupus erythematosus. While dermoscopy and videodermoscopy have been shown to aid the differentiation of scalp DLE from other causes of scarring alopecia, limited data exist concerning dermoscopic criteria of DLE in other locations, such as the face, trunk and extremities...
February 2013: British Journal of Dermatology
S Wahie, S J Meggitt
BACKGROUND: The recommended first-line oral therapy for discoid lupus erythematosus (DLE) is the antimalarial hydroxychloroquine. To the best of our knowledge, there is no published information regarding the long-term (i.e. > 6 months) response of DLE to hydroxychloroquine in clinical practice. OBJECTIVES: To describe the long-term clinical response of DLE to hydroxychloroquine after 6 months of use. METHODS: A multicentre retrospective cohort study was conducted in patients with DLE who had received treatment with hydroxychloroquine...
September 2013: British Journal of Dermatology
S Martin-Rodriguez, J C Reverter, D Tàssies, G Espinosa, M Heras, M Pino, G Escolar, M Diaz-Ricart
BACKGROUND: Severe deficiency of ADAMTS13 activity leads to von Willebrand factor (VWF) ultralarge multimers with high affinity for platelets, causing thrombotic thrombocytopenic purpura. Other pathological conditions with moderate ADAMTS13 activity exhibit a thrombotic risk. We examined the ADAMTS13 activity in systemic lupus erythematosus (SLE) and its value as a thrombotic biomarker. METHODS: ADAMTS13 activity, VWF antigen and multimeric structure, and vascular cell adhesion molecule 1 (VCAM-1) were measured in plasma samples from 50 SLE patients and 50 healthy donors...
October 2015: Lupus
S T Everett, R Wolf, I Contento, V Haiduc, M Richey, D Erkan
BACKGROUND: Patients with systemic lupus erythematosus (SLE) are at a high risk for cardiovascular disease (CVD) due to increased prevalence of traditional and nontraditional CVD risks factors. OBJECTIVE: To evaluate the effect of patient-centered nutrition counseling methods on changes in select nutrient, anthropometric, and clinical outcomes in SLE patients enrolled in a CVD prevention counseling program (CVD PCP). METHODS: From March 2009 to June 2011 a subgroup of SLE patients enrolled in our CVD PCP were referred to a registered dietitian for individualized nutrition counseling...
October 2015: Lupus
Josef S Smolen, Daniel Aletaha
Rheumatoid arthritis (RA) is considered a chronic disease that cannot be cured. Biologic agents have enabled good therapeutic successes; however, the response to biologic therapy depends on treatment history and, especially, disease duration. In general, the more drug-experienced the patients, the lower the response rates, although this limitation can be overcome by promptly adjusting or switching treatment in a treat-to-target approach. Another challenge is the question of how long therapy should be continued once the treatment target, which should be remission or at least a state of low disease activity, has been reached...
May 2015: Nature Reviews. Rheumatology
2015-05-13 04:39:33
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