David Axelson, Benjamin Goldstein, Tina Goldstein, Kelly Monk, Haifeng Yu, Mary Beth Hickey, Dara Sakolsky, Rasim Diler, Danella Hafeman, John Merranko, Satish Iyengar, David Brent, David Kupfer, Boris Birmaher
OBJECTIVE: The authors sought to identify diagnostic risk factors of manic, mixed, or hypomanic episodes in the offspring of parents with bipolar disorder ("high-risk offspring"). METHOD: High-risk offspring 6-18 years old (N=391) and demographically matched offspring (N=248) of community parents without bipolar disorder were assessed longitudinally with standardized diagnostic instruments by staff blind to parental diagnoses. Follow-up assessments were completed in 91% of the offspring (mean follow-up interval, 2...
July 2015: American Journal of Psychiatry