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ANCA Vasculitis Renal Involvement

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46 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
https://read.qxmd.com/read/31088509/rituximab-in-relapsing-and-de-novo-mpo-anca-associated-vasculitis-with-severe-renal-involvement-a-case-series
#1
L Caroti, C L Cirami, L Di Maria, A Larti, P Carta, E Dervishi, S Farsetti, A Tsalouchos, L Novelli, E E Minetti
BACKGROUND: Antineutrophil cytoplasmic antibody associated vasculitis (AAV) is a group of diseases associated in most cases with the presence of anti-neutrophil cytoplasmic antibodies (ANCAs). Rituximab- based remission induction has been proven effective in ANCA associated vasculitis but scarce data exist in forms with severe renal involvement. In this case series, we report the outcomes in patients with de novo or recurrent MPO-AAV and severe renal involvement treated with rituximab without cyclophosphamide (CYC)...
May 14, 2019: BMC Nephrology
https://read.qxmd.com/read/31049594/subclassifying-anca-associated-vasculitis-a-unifying-view-of-disease-spectrum
#2
Alfred Mahr, Ulrich Specks, David Jayne
No abstract text is available yet for this article.
May 3, 2019: Rheumatology
https://read.qxmd.com/read/31053735/gremlin-a-potential-urinary-biomarker-of-anca-associated-crescentic-glomerulonephritis
#3
Alejandra Droguett, Graciela Valderrama, María E Burgos, Daniel Carpio, Constanza Saka, Jesús Egido, Marta Ruiz-Ortega, Sergio Mezzano
Gremlin renal overexpression has been reported in diabetic nephropathy, pauci-immune crescentic glomerulonephritis and chronic allograft nephropathy and has been implicated in the pathophysiology of the progression of renal damage. However, it is unknown whether urinary Gremlin can be associated with renal functional status, renal biopsy findings and outcome. To examine these associations we studied 20 patients with ANCA+ renal vasculitis and very high urinary Gremlin (354 ± 76 ug/gCr), 86 patients with other glomerular diseases and moderately elevated urinary Gremlin (83 ± 14 ug/gCr) and 11 healthy controls (urinary Gremlin 11...
May 3, 2019: Scientific Reports
https://read.qxmd.com/read/31033151/plasma-exchange-is-highly-effective-for-anca-associated-vasculitis-patients-with-rapidly-progressive-glomerulonephritis-who-have-advanced-to-dialysis-dependence-a-single-center-case-series
#4
Reimi Nishida, Shuzo Kaneko, Joichi Usui, Tetsuya Kawamura, Ryoya Tsunoda, Takashi Tawara, Akiko Fujita, Kei Nagai, Hirayasu Kai, Naoki Morito, Chie Saito, Kunihiro Yamagata
Plasma exchange (PEX) can be an effective treatment in ANCA-associated vasculitis (AAV) with severe renal damage; however, it is still controversial. Among cases of newly diagnosed AAV with rapidly progressive glomerulonephritis (AAV-RPGN) at our department from 2008 onward, eleven patients who received PEX (7 cases for severe renal damage (R-PEX) and 4 cases for lung hemorrhage (L-PEX)) were retrospectively analyzed. All cases of R-PEX were dependent on hemodialysis at the beginning of PEX and all received 7 sessions of PEX (50 ml/kg or 1...
April 29, 2019: Therapeutic Apheresis and Dialysis
https://read.qxmd.com/read/31037456/uncommon-presentations-in-anca-vasculitis-clinical-characteristics-and-outcomes
#5
Veena S Katikeneni, Sam Kant, Eric J Gapud, Brendan Antiochos, Rebecca L Manno, Michael Phillips, Philips Seo, Duvuru Geetha
ANCA-associated vasculitis (AAV) can present in an atypical manner and obscure the clinical picture. We sought to characterize clinical characteristics and outcomes in these uncommon presentations. We conducted a retrospective study of 171 AAV patients in our vasculitis database to identify patients with atypical presentation of AAV. Patient demographics, serologies, renal indices, and treatment regimens were assessed. Of the 171 patients, eight were identified to have uncommon presentations. These patients were usually extremes of age with three being less than 30 years and four being more than 70 years...
April 29, 2019: Clinical Rheumatology
https://read.qxmd.com/read/31022055/thirty-day-hospital-readmissions-for-granulomatosis-with-polyangiitis-in-the-united-states-a-nationwide-analysis
#6
Yiming Luo, Changchuan Jiang, Ana Belen Arevalo Molina, Shane Murray, Gustavo Contreras Anez, Maria Salgado, Jiehui Xu
BACKGROUND/OBJECTIVE: Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis that often results in frequent hospitalizations. We investigated the characteristics and predictors of 30-day hospital readmissions in GPA. METHODS: We performed a cross-sectional analysis using the 2014 National Readmission Database. We included nonelective admissions with a primary or secondary diagnosis of GPA. We compared characteristics between readmissions and nonreadmissions...
April 22, 2019: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/30981399/withdrawn-treatment-of-anca-associated-vasculitides-certainties-and-controversies
#7
Benjamin Terrier
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal .
April 2019: Néphrologie & Thérapeutique
https://read.qxmd.com/read/30945174/a-relapsing-case-of-pulmonary-renal-syndrome-after-a-sequential-rise-in-mpo-anca-and-anti-gbm-antibodies
#8
Akiko Hoshino, Toru Sakairi, Ken Kayakabe, Masahito Baba, Masayasu Ando, Hayato Kimura, Rena Motohashi, Yoshihisa Nojima, Keiju Hiromura
A 69-year-old woman who presented with severe renal dysfunction and diffuse alveolar hemorrhage was diagnosed with pulmonary-renal syndrome (PRS) based on the coexistence of serum myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA) and anti-glomerular basement membrane (GBM) antibodies (Ab). Hemodialysis was started; plasma exchange and intravenous methylprednisolone pulse therapy were administered followed by oral prednisolone administration. Pulmonary hemorrhage decreased; however, renal dysfunction persisted...
April 3, 2019: CEN Case Reports
https://read.qxmd.com/read/30197970/comparisons-of-guidelines-and-recommendations-on-managing-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#9
REVIEW
Duvuru Geetha, Qiuyu Jin, Jennifer Scott, Zdenka Hruskova, Mohamad Hanouneh, Mark A Little, Vladimir Tesar, Philip Seo, David Jayne, Christian Pagnoux
Antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) is associated with high morbidity or mortality, especially if not promptly diagnosed and treated. Many inroads have been made in the understanding of the pathophysiology that leads to exploration of novel therapies. Randomized controlled trials over the last 2 decades have better delineated and expanded therapeutic options and set the stage for an evidence-based approach. Since 2014, 4 scientific societies have systematically reviewed the existing data and have formulated evidence-based recommendations for the management of AAV...
September 2018: KI Reports
https://read.qxmd.com/read/30837045/-effect-of-glucocorticoid-pulse-therapy-on-short-term-prognosis-of-anti-neutrophil-cytoplasmic-antibodies-associated-glomerulonephritis
#10
Hai Ting Wu, Hang Li, Wei Ye, Jian Fang Cai, Yu Bing Wen, Li Meng Chen, Ming Xi Li, Xue Mei Li
Objective To investigate the prognosis predictors of anti-neutrophil cytoplasmic antibody(ANCA)-associated glomerulonephritis treated with glucocorticoid(GC).Methods The clinicopathological data of patients with biopsy-confirmed ANCA-associated glomerulonephritis were retrospective analyzed by retrieving the medical database in Peking Union Medical College Hospital from January 2000 to May 2015. Pathological categories were re-classified. Renal remission rates,infection rates,and death events were compared between intravenous glucocorticoid(GC)pulse therapy group and non-pulse group...
February 28, 2019: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://read.qxmd.com/read/30834449/editorial-a-new-era-in-anti-neutrophil-cytoplasmic-antibody-vasculitis
#11
Denis Fouque, Fernando C Fervenza
No abstract text is available yet for this article.
March 1, 2019: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/30714492/diagnosis-and-treatment-of-autoinflammatory-diseases-in-adults-a-clinical-approach-from-rheumatologists
#12
Tomohiro Koga, Atsushi Kawakami
Autoinflammatory diseases are characterized by recurrent systemic inflammation due to dysfunction of the innate immune system, and they are originally the hereditary recurrent fever syndromes that develop in early childhood. Many cases are thus diagnosed in the pediatric field, but there are many cases that are not diagnosed until adulthood, including adult-onset cases. Accordingly, not only pediatricians but also rheumatologists and primary care physicians play a major role in the diagnosis and treatment of autoinflammatory diseases...
February 3, 2019: Immunological medicine
https://read.qxmd.com/read/30777023/intravenous-pulse-methylprednisolone-for-induction-of-remission-in-severe-anca-associated-vasculitis-a-multi-center-retrospective-cohort-study
#13
Dimitrios Chanouzas, Julie Anne G McGregor, Peter Nightingale, Alan D Salama, Wladimir M Szpirt, Neil Basu, Matthew David Morgan, Caroline J Poulton, Juliana Bordignon Draibe, Elizabeth Krarup, Paula Dospinescu, Jessica Anne Dale, William Franklin Pendergraft, Keegan Lee, Martin Egfjord, Susan L Hogan, Lorraine Harper
BACKGROUND: Intravenous pulse methylprednisolone (MP) is commonly included in the management of severe ANCA associated vasculitis (AAV) despite limited evidence of benefit. We aimed to evaluate outcomes in patients who had, or had not received MP, along with standard therapy for remission induction in severe AAV. METHODS: We retrospectively studied 114 consecutive patients from five centres in Europe and the United States with a new diagnosis of severe AAV (creatinine > 500 μmol/L or dialysis dependency) and that received standard therapy (plasma exchange, cyclophosphamide and high-dose oral corticosteroids) for remission induction with or without pulse MP between 2000 and 2013...
February 18, 2019: BMC Nephrology
https://read.qxmd.com/read/30746129/comparing-outcomes-of-biopsy-proven-anti-neutrophil-cytoplasmic-autoantibody-associated-glomerulonephritis-patients-treated-with-cyclophosphamide-in-the-20th-and-21st-centuries-a-23-year-study
#14
Steven Whatmough, Sophie Fernandez, Niamh Sweeney, Laura Howell, Ajay Dhaygude
Background: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a multisystem autoimmune disorder associated with significant morbidity and mortality. Approximately 80-90% of patients have circulating ANCAs. Long-term outcomes appear to be improving. This retrospective study analyses the incidence and patient outcomes over a period of 23 years at a single tertiary centre. Methods: Outcomes of patients diagnosed with AAV between 1 January 1988 and 31 December 2010 were collected retrospectively...
February 2019: Clinical Kidney Journal
https://read.qxmd.com/read/30607566/clinical-and-histopathological-prognostic-factors-affecting-the-renal-outcomes-in-childhood-anca-associated-vasculitis
#15
Gül Özçelik, Hafize Emine Sönmez, Sezgin Şahin, Ayşim Özağarı, Meral Torun Bayram, Rümeysa Yasemin Çiçek, Evrim Kargın Çakıcı, Elif Çomak, Kenan Barut, Nihal Şahin, Sevcan Bakkaloğlu, İbrahim Gökçe, Ali Düzova, Yelda Bilginer, Ceyhun Açarı, Engin Melek, Beltinge Demircioğlu Kılıç, Semanur Özdel, Amra Adroviç, Özgür Kasapçopur, Erbil Ünsal, Harika Alpay, Diclehan Orhan, Rezan Topaloğlu, Ruhan Düşünsel, Seza Özen
OBJECTIVE: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are very rare in childhood with an increased risk of morbidity and mortality. We aimed to evaluate renal prognostic factors in childhood AAV from the perspective of ANCA serotype, histopathological classification, and five-factor score (FFS). METHODS: Pediatric AAV patients from 11 referral centers in Turkey had been included to the study. The demographics, clinical findings, AAV subtypes, outcomes, and FFS were evaluated retrospectively...
May 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30538527/antineutrophil-cytoplasmic-antibody-associated-vasculitis-update-on-molecular-pathogenesis-diagnosis-and-treatment
#16
REVIEW
Farid Arman, Marina Barsoum, Umut Selamet, Hania Shakeri, Olivia Wassef, Mira Mikhail, Anjay Rastogi, Ramy M Hanna
Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. We also review the molecular pathology behind ANCAs and associated antigens and infections...
2018: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/30526900/investigations-in-systemic-vasculitis-the-role-of-renal-pathology
#17
REVIEW
Annelies E Berden, Maria A C Wester Trejo, Ingeborg M Bajema
ANCA-associated vasculitis (AAV) describes a group of small-vessel vasculitides with frequent renal involvement. The first description of these conditions can be traced back to the 19th-century paper on necrotizing vasculitis by Kussmaul and Maier. Since then, our understanding of the pathogenesis has improved and the histopathological lesions have been described in detail. Characteristic histologic lesions in ANCA-associated glomerulonephritis (AAGN) are fibrinoid necrosis and crescents, often accompanied by tubulointerstitial inflammation...
February 2018: Best Practice & Research. Clinical Rheumatology
https://read.qxmd.com/read/30472653/prevention-of-infections-in-patients-with-antineutrophil-cytoplasm-antibody-associated-vasculitis-potential-role-of-hydroxychloroquine
#18
Pavel I Novikov, Nikolai M Bulanov, Anastasiia S Zykova, Sergey V Moiseev
No abstract text is available yet for this article.
November 24, 2018: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30487151/cardiovascular-thromboembolic-and-renal-outcomes-in-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura-a-retrospective-cohort-study-using-routinely-collected-primary-care-data
#19
Alexander Tracy, Anuradhaa Subramanian, Nicola J Adderley, Paul Cockwell, Charles Ferro, Simon Ball, Lorraine Harper, Krishnarajah Nirantharakumar
BACKGROUND: IgA vasculitis (IgAV, Henoch-Schönlein purpura) is a small-vessel vasculitis most common in children but also occurring in adults. Case series have suggested that IgAV may be associated with cardiovascular disease and venous thromboembolism, but this has not been evaluated in population-based studies. Renal disease and hypertension are possible complications of the disease with unknown incidence. METHODS: Using a large UK primary care database, we conducted an open retrospective matched cohort study of cardiovascular, venous thrombotic and renal outcomes in adult-onset and childhood-onset IgAV...
February 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30466561/anca-renal-risk-score-is-prediction-of-end-stage-renal-disease-at-baseline-possible
#20
COMMENT
Andreas Kronbichler, David R W Jayne
Despite improved overall prognosis of patients with ANCA-associated vasculitis (AAV), those presenting with impaired renal function remain at risk of developing end-stage renal disease (ESRD). In addition to its role in diagnosis, renal histology provides prognostic information that has permitted definition of subgroups with differing risks of ESRD. In this issue, Brix et al. have developed and validated a risk score to predict the probability of ESRD. Against a background of outcome prediction in AAV, this commentary assesses different approaches to histologic risk and to what extent they assist with decisions on patient management...
December 2018: Kidney International
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