A B Niculescu, D F Levey, P L Phalen, H Le-Niculescu, H D Dainton, N Jain, E Belanger, A James, S George, H Weber, D L Graham, R Schweitzer, T B Ladd, R Learman, E M Niculescu, N P Vanipenta, F N Khan, J Mullen, G Shankar, S Cook, C Humbert, A Ballew, M Yard, T Gelbart, A Shekhar, N J Schork, S M Kurian, G E Sandusky, D R Salomon
Worldwide, one person dies every 40 seconds by suicide, a potentially preventable tragedy. A limiting step in our ability to intervene is the lack of objective, reliable predictors. We have previously provided proof of principle for the use of blood gene expression biomarkers to predict future hospitalizations due to suicidality, in male bipolar disorder participants. We now generalize the discovery, prioritization, validation, and testing of such markers across major psychiatric disorders (bipolar disorder, major depressive disorder, schizoaffective disorder, and schizophrenia) in male participants, to understand commonalities and differences...
November 2015: Molecular Psychiatry