Arri Coomarasamy, Helen Williams, Ewa Truchanowicz, Paul T Seed, Rachel Small, Siobhan Quenby, Pratima Gupta, Feroza Dawood, Yvonne E M Koot, Ruth Bender Atik, Kitty W M Bloemenkamp, Rebecca Brady, Annette L Briley, Rebecca Cavallaro, Ying C Cheong, Justin J Chu, Abey Eapen, Ayman Ewies, Annemieke Hoek, Eugenie M Kaaijk, Carolien A M Koks, Tin-Chiu Li, Marjory MacLean, Ben W Mol, Judith Moore, Jackie A Ross, Lisa Sharpe, Jane Stewart, Nirmala Vaithilingam, Roy G Farquharson, Mark D Kilby, Yacoub Khalaf, Mariette Goddijn, Lesley Regan, Rajendra Rai
BACKGROUND: Progesterone is essential for the maintenance of pregnancy. However, whether progesterone supplementation in the first trimester of pregnancy would increase the rate of live births among women with a history of unexplained recurrent miscarriages is uncertain. METHODS: We conducted a multicenter, double-blind, placebo-controlled, randomized trial to investigate whether treatment with progesterone would increase the rates of live births and newborn survival among women with unexplained recurrent miscarriage...
November 26, 2015: New England Journal of Medicine