J Pablo Abonia, Ting Wen, Emily M Stucke, Tommie Grotjan, Molly S Griffith, Katherine A Kemme, Margaret H Collins, Philip E Putnam, James P Franciosi, Karl F von Tiehl, Brad T Tinkle, Keith A Marsolo, Lisa J Martin, Stephanie M Ware, Marc E Rothenberg
BACKGROUND: Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease mediated by immune hypersensitization to multiple foods and strongly associated with atopy and esophageal remodeling. OBJECTIVE: We provide clinical and molecular evidence indicating a high prevalence of EoE in patients with inherited connective tissue disorders (CTDs). METHODS: We examined the rate of EoE among patients with CTDs and subsequently analyzed esophageal mRNA transcript profiles in patients with EoE with or without CTD features...
August 2013: Journal of Allergy and Clinical Immunology