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Uremic Pruritus

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58 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Natalie Plewig, Robert Ofenloch, Thomas Mettang, Elke Weisshaar
BACKGROUND: Chronic itch (CI) is a frequent symptom in hemodialysis (HD) patients. Previous studies demonstrated great impairments of general well-being and health-related quality of life (HRQOL) as well as a higher mortality in those suffering from CI. OBJECTIVE: The German Epidemiological Hemodialysis Itch Study (GEHIS) is a representative cohort of HD patients in Germany. All patients were followed-up 4 years later. The current analyses present data on the course of CI in HD patients, its associated factors including comorbidities, laboratory values and HRQOL...
February 11, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Nese Altınok Ersoy, İmatullah Akyar
BACKGROUND: Pruritus is a distressing, life-limiting symptom in chronic renal failure, affecting 40% of patients. This study aimed to determine uremic pruritus prevalence and investigate the multidimensional impact on hemodialysis patients. METHODS: This descriptive study was performed between March and June 2016. The study included 181 patients undergoing hemodialysis session, who reported pruritus in the prior month. Data were collected using the 5-D Itch Scale, which assesses pruritus based on 5 dimensions, i...
February 6, 2019: BMC Nephrology
Katarzyna Grochulska, Robert F Ofenloch, Thomas Mettang, Elke Weisshaar
The GEHIS (German Epidemiological Hemodialysis Itch Study) is a representative cohort study started in 2013 with 860 haemodialysis (HD) patients in 25 German dialysis units. Chronic itch (CI) has been reported to be a poor prognostic marker for patients on HD; however, this has not been investigated in a representative patient cohort. In 2017, all HD patients were contacted again to investigate mortality in those with and without CI and to identify its determinants. Patients' characteristics, study instruments and CI were assessed, as in 2013...
January 23, 2019: Acta Dermato-venereologica
Severin Schricker, Thorsten Heider, Moritz Schanz, Jürgen Dippon, Mark Dominik Alscher, Heinz Weiss, Thomas Mettang, Martin Kimmel
Pruritus, impaired mental health and inflammation contribute to morbidity in end-stage renal disease. There are no studies on all three conditions. We therefore obtained inflammatory parameter data (C-reactive protein and interleukin-6), pruritus data and psychological test data (36-Item Short-Form Health Survey, "Allgemeine Depressionsskala" and Toronto Alexithymia Scale-20) for 19 dialysis patients with pruritus, 20 dialysis patients without pruritus and 15 healthy controls. Non-parametric hierarchical clustering revealed three clusters of parameters: one mainly driven by pruritus scores (chronic kidney disease-associated pruritus cluster), one by mental health scores (mental health cluster) and one by inflammatory parameters (inflammatory cluster)...
January 23, 2019: Acta Dermato-venereologica
Arian Pourmehdi Lahiji, Mojgan Mortazavi, Shahnaz Amani Tirani, Firouzeh Moeinzadeh, Ehsan Zarea Bidaki, Afsoon Emami Naini, Gita Faghihi, Arash Toghyani, Ziba Farajzadegan
Objective: Pruritus is a prevalent skin condition in end-stage renal disease patients. Omega-3 fatty acids have been shown to reduce pruritus in hemodialysis patients. Our objective was to assess the effect of 3 g/day omega-3 supplementation on pruritus among continuous ambulatory peritoneal dialysis (CAPD) patients. Methods: In this two-period, two-sequence crossover randomized clinical trial, 40 eligible subjects (CAPD patients who complained of pruritus for more than 8 weeks) were randomized to 3 g of omega-3 ( n = 20) or identical placebo capsules ( n = 20) for 4 weeks...
October 2018: Journal of Research in Pharmacy Practice
Inayat Ur Rehman, Syed Munib, Amutha Ramadas, Tahir Mehmood Khan
BACKGROUND: The prevalence of chronic kidney disease-associated pruritus (CKD-aP) varies from 22% to 84% among patients receiving hemodialysis. It occurs more frequently at night, and often affects patient's sleep quality. CKD-aP is often unreported by patients, and many do not receive effective treatment. There is, however, a paucity of available data on the prevalence and impact of CKD-aP on patients receiving hemodialysis in Pakistan. METHODS: A multicenter cross-sectional study was undertaken from July 2016 to April 2017 at a tertiary care hospitals in Pakistan...
2018: PloS One
Deep Jaiswal, Drea Uzans, Jill Hayden, Bryce A Kiberd, Karthik K Tennankore
BACKGROUND: Patients undergoing hemodialysis or peritoneal dialysis often experience pruritus which is associated with morbidity and mortality. One proposed treatment approach is to target the opioid pathway using either µ-opioid antagonists or κ-opioid agonists. OBJECTIVE: To review the efficacy of targeting the opioid pathway for pruritus among dialysis patients (uremic pruritus). DESIGN: Systematic review and meta-analysis. SETTING/METHODS: The systematic review included randomized controlled and randomized crossover trials identified in the MEDLINE, EMBASE, and Cochrane databases (1990 to June 2014) evaluating the efficacy of µ-opioid antagonists or κ-opioid agonists in the treatment of uremic pruritus...
2016: Canadian Journal of Kidney Health and Disease
Ching-Wei Hsu, Cheng-Hao Weng, Ming-Jen Chan, Dan-Tzu Lin-Tan, Tzung-Hai Yen, Wen-Hung Huang
Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels...
November 22, 2018: Scientific Reports
Chun-Yang Tseng, Tai-Te Wu, Chia-Wen Lai, Hsuan-Jen Lin, Che-Yi Chou, Chiz-Tzung Chang, Hung-Chih Chen
OBJECTIVES: Systemic inflammation has been reported to be associated with uremic pruritus (UP). Although a vegetarian diet can reduce systemic inflammation in hemodialysis patients, the effect of vegetarian diet on UP is not clear. The purpose of the study was to know the possible effects of vegetarian diet on UP. METHODS: A cross-sectional study was done to compare the severity of UP and blood levels of systemic inflammatory markers between vegetarian and non-vegetarian hemodialysis patients...
November 2018: Renal Failure
Adesuyi A L Ajayi
Chloroquine (CQ) is an antimalarial drug that elicits severe pruritus in black Africans with malaria fever. This acute itching (2-7 days duration) exhibits age dependency and a racial and genetic predilection. CQ itch is non-histaminergic, which makes it both a good model and a tool to probe the mechanisms of chronic itch. This review focuses on recently discovered mechanisms, neuroscience, mediators, and receptors that are implicated in molecular studies of CQ pruritus. CQ pruritus mechanisms are also compared to that of itching following other systemic diseases, such as chronic kidney disease, chronic liver disease, skin disorders, and burns...
October 26, 2018: International Journal of Dermatology
Shawn G Kwatra, Sonja Ständer, Hyunseok Kang
New England Journal of Medicine, Volume 379, Issue 16, Page 1578-1579, October 2018.
October 18, 2018: New England Journal of Medicine
Zhi-Qiang Xie, Jun-Zhou Fu, Gan Chen, Chang-Jie Guan, Wen-Hu Liu, Li-Yan Wang, Moritake Sadanobu, Wenting Wu, Kawashima Makoto
Objective To preliminarily validate the clinical usability of the ameliorated Kawashima Itch Scale(Xie-Kawashima Itch Scale) among adult pruritic patients on maintenance hemodialysis. Methods Xie-Kawashima Itch Scale was developed on the basis of Kawashima Itch Scale. Patients were asked to record their pruritus condition according to Xie-Kawashima Itch Scale or visual analogue scale(VAS) during daytime and night for two weeks. The record at the second week was used for analyzing the correlation between Xie-Kawashima Itch Scale and VAS...
August 30, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Leila Malekmakan, Taraneh Tadayon, Maryam Pakfetrat, Afshin Mansourian, Neda Zareei
Till now many treatments attempted to relieve uremic pruritus (UP) though none of them are definite treatment. In this study, we gathered all studies conducted on UP treatment since 2000-2016. We conducted a systematic review by searching the electronic databases (PubMed, Scopus, and Google scholar). Patients were with chronic kidney disease who complained of UP. Clinical trials and pilot studies in English and Persian which were done on patients with ESRD who complained of itching between 2000 till 2016 were gathered...
September 2018: Dermatologic Therapy
Ranjeeta Sapam, Rajesh Waikhom
AIM: To assess the role of narrow band ultraviolet B (UVB) as a treatment option in peritoneal dialysis patients with refractory uremic pruritus. METHODS: In this retrospective study, 29 adult patients with end stage renal failure on peritoneal dialysis, and who had refractory uremic pruritus, were given narrow band UVB radiation as an add-on therapy to standard care for a duration of 12 wk. The response to the pruritus was assessed both weekly and at the end of the study period using a visual analogue score (VAS)...
August 7, 2018: World Journal of Nephrology
Inayat Ur Rehman, David Bin-Chia Wu, Raheel Ahmed, Nisar Ahmad Khan, Aziz Ur Rahman, Syed Munib, Learn Han Lee, Kok Gan Chan, Tahir Mehmood Khan
BACKGROUND: Pruritus adds to the complications of chronic kidney disease (CKD) patient and a well-recognized complication among the CKD patients. Majority of the patients on hemodialysis experience a generalized pruritus and patients reported being moderately to extremely disturbed by at least one of the sleep-related condition. This study aim to investigate the effectiveness of zolpidem 10 mg and acupressure therapy on foot acupoints to improve the sleep quality and overall quality of life among hemodialysis patients suffering from CKD-associated pruritus...
August 2018: Medicine (Baltimore)
Soo Hyeon Noh, Kun Park, Eun Jung Kim
No abstract text is available yet for this article.
August 2018: Annals of Dermatology
Jéssica Dantas de Sá Tinôco, Maria das Graças Mariano Nunes de Paiva, Beatriz Medeiros de Macedo, Marcelly Santos Cossi, Millena Freire Delgado, Ana Luisa Brandão de Carvalho Lira
OBJECTIVE: To analyze the association between the occurrence of pruritus and adherence to the prescribed diet, biochemical indicators of renal function and the quality of hemodialysis in chronic renal patients. METHOD: A cross-sectional study performed at a dialysis clinic in the Northeast of Brazil, with 200 patients undergoing hemodialysis in the first half of 2015.To analyze the data, inferential statistics were used, using Chi-Square and Fisher's Exact tests; and Mann Whitney U test...
July 23, 2018: Revista Gaúcha de Enfermagem
Naoko Takahashi, Taku Yoshizawa, Shinichiro Tsuchiya
BACKGROUND: Hemodialysis-associated pruritus (HAP) is often treatment-resistant, and is a serious comorbidity that adversely affects prognosis and reduces patient quality of life through sleep disruption and depression. SUMMARY: HAP can arise from a combination of several causes; accordingly, it is often resistant to treatment. HAP patients need the specific causes of their itching to be identified, with a comprehensive approach to treatment. We have implemented our own therapeutic algorithm, which covers cause specification, for HAP since June 2009...
2018: Contributions to Nephrology
Franz J Legat
Phototherapy and photochemotherapy (PUVA) are important treatment modalities in inflammatory skin diseases such as psoriasis and atopic dermatitis as well as in cutaneous T‑cell lymphoma (e.g., mycosis fungoides/Sezary syndrome). Many of these skin diseases are accompanied by distracting pruritus. In addition, patients may suffer from intense pruritus in systemic diseases of the kidney and liver as well as of the endocrine and hematopoietic system. UV-light during phototherapy is capable of not only improving the inflammatory skin lesions but also of reducing the pruritus in skin and systemic diseases...
July 13, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Nurten Ozen, Fatma Ilknur Cinar, Dilek Askin, Dilek Mut
Background: Uremic pruritus is a common and disturbing problem in hemodialysis patients. Although its pathogenesis is not completely understood, it is thought to be multifactorial. The aim of this study was to identify risk factors of uremic pruritus in hemodialysis patients. Methods: A total of 249 patients from four dialysis centers were included in this study. Data were collected using a questionnaire, the visual analogue scale, and the Hospital Anxiety and Depression Scale...
June 2018: Kidney Research and Clinical Practice
2018-07-06 09:51:39
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