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GMG Nutritional/Cardiac

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263 papers 25 to 100 followers
By Gregory Gustafson Interventional Cardiologist
https://read.qxmd.com/read/30694827/triglycerides-and-triglyceride-rich-lipoproteins-in-the-development-and-progression-of-atherosclerosis
#1
Giuliano Generoso, Carolina C P S Janovsky, Marcio S Bittencourt
PURPOSE OF REVIEW: In this review, we intend to show the heterogenicity of the triglyceride group, including the triglyceride-rich lipoproteins and its subparticles, apolipoproteins, and its role in atherogenesis through epidemiological and genetic studies, observing the association of these various components and subclasses with subclinical atherosclerosis and cardiovascular events. Also, we reevaluated the moment of blood collection for the triglyceride measurement and its repercussion in atherosclerosis...
January 28, 2019: Current Opinion in Endocrinology, Diabetes, and Obesity
https://read.qxmd.com/read/30624670/randomized-controlled-trial-of-vitamin-d-supplementation-in-older-people-to-optimize-bone-health
#2
Terry J Aspray, Thomas Chadwick, Roger M Francis, Elaine McColl, Elaine Stamp, Ann Prentice, Alexander von Wilamowitz-Moellendorff, Inez Schoenmakers
Background: Vitamin D insufficiency is common in older people and may lead to increased bone resorption, bone loss, and increased falls and fractures. However, clinical trials assessing the effect of vitamin D supplementation on bone mineral density (BMD) have yielded conflicting results. Objectives: This study examined the effect of vitamin D supplementation on BMD at the hip, using dual-energy X-ray absorptiometry. Methods: A total of 379 adults aged ≥70 y (48% women; mean age: 75 y) from the northeast of England were randomly allocated to 1 of 3 doses of vitamin D3 [12,000 international units (IU), 24,000 IU, or 48,000 IU] given once a month...
January 8, 2019: American Journal of Clinical Nutrition
https://read.qxmd.com/read/30629107/habitual-consumption-of-long-chain-n-3-pufas-and-fish-attenuates-genetically-associated-long-term-weight-gain
#3
Tao Huang, Tiange Wang, Yoriko Heianza, Yan Zheng, Dianjianyi Sun, Jae H Kang, Louis R Pasquale, Eric B Rimm, JoAnn E Manson, Frank B Hu, Lu Qi
Background: A growing amount of data suggests that n-3 (ω-3) polyunsaturated fatty acid (PUFA) intake may modify the genetic association with weight change. Objectives: We aimed to prospectively test interactions of habitual consumption of n-3 PUFAs or fish, the major food source, with overall genetic susceptibility on long-term weight change. Design: Gene-diet interactions were examined in 11,330 women from the Nurses' Health Study (NHS), 6773 men from the Health Professionals Follow-Up Study (HPFS), and 6254 women from the Women's Health Initiative (WHI)...
January 9, 2019: American Journal of Clinical Nutrition
https://read.qxmd.com/read/30571591/anti-inflammatory-effects-of-a-vegan-diet-versus-the-american-heart-association-recommended-diet-in-coronary-artery-disease-trial
#4
Binita Shah, Jonathan D Newman, Kathleen Woolf, Lisa Ganguzza, Yu Guo, Nicole Allen, Judy Zhong, Edward A Fisher, James Slater
Background Dietary interventions may play a role in secondary cardiovascular prevention. hsCRP (High-sensitivity C-reactive protein) is a marker of risk for major adverse cardiovascular outcomes in coronary artery disease. Methods and Results The open-label, blinded end-point, EVADE CAD (Effects of a Vegan Versus the American Heart Association-Recommended Diet in Coronary Artery Disease) trial randomized participants (n=100) with coronary artery disease to 8 weeks of a vegan or American Heart Association-recommended diet with provision of groceries, tools to measure dietary intake, and dietary counseling...
December 4, 2018: Journal of the American Heart Association
https://read.qxmd.com/read/30541098/diurnal-distribution-of-carbohydrates-and-fat-affects-substrate-oxidation-and-adipokine-secretion-in-humans
#5
Katharina Kessler, Silke Hornemann, Klaus J Petzke, Margrit Kemper, Mariya Markova, Natalia Rudovich, Tilman Grune, Achim Kramer, Andreas F H Pfeiffer, Olga Pivovarova-Ramich
Background: A diet in which fat is mainly eaten in the morning and carbohydrates mainly in the evening (compared with the reverse order) was recently shown to worsen glycemic control in people with prediabetes. Objective: We investigated the effects of these dietary patterns on energy metabolism, and on the daily profiles of circulating lipids, adipokines, and inflammatory markers. Design: In a randomized controlled crossover trial, 29 nonobese men (with normal glucose tolerance, n = 18; or impaired fasting glucose/glucose tolerance, n = 11) underwent 2 isocaloric 4-wk diets: 1) carbohydrate-rich meals until 1330 and fat-rich meals between 1630 and 2200 (HC/HF); or 2) the inverse sequence of meals (HF/HC)...
December 1, 2018: American Journal of Clinical Nutrition
https://read.qxmd.com/read/30484282/polyunsaturated-fatty-acids-for-the-primary-and-secondary-prevention-of-cardiovascular-disease
#6
REVIEW
Asmaa S Abdelhamid, Nicole Martin, Charlene Bridges, Julii S Brainard, Xia Wang, Tracey J Brown, Sarah Hanson, Oluseyi F Jimoh, Sarah M Ajabnoor, Katherine Ho Deane, Fujian Song, Lee Hooper
BACKGROUND: Evidence on the health effects of total polyunsaturated fatty acids (PUFA) is equivocal. Fish oils are rich in omega-3 PUFA and plant oils in omega-6 PUFA. Evidence suggests that increasing PUFA-rich foods, supplements or supplemented foods can reduce serum cholesterol, but may increase body weight, so overall cardiovascular effects are unclear. OBJECTIVES: To assess effects of increasing total PUFA intake on cardiovascular disease and all-cause mortality, lipids and adiposity in adults...
November 27, 2018: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/29983721/a-study-on-the-relationship-between-waist-phenotype-hypertriglyceridemia-coronary-artery-lesions-and-serum-free-fatty-acids-in-adult-and-elderly-patients-with-coronary-diseases
#7
Rui-Feng Yang, Hanlei Zhang, Zhongchun Wang, Xiao-Yong Liu, Zhi Lin
Background: Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD. Methods: We enrolled patients with coronary heart disease in our hospital from October 2008 to July 2009. Patients with high TG and increased WC, i.e. waist phenotype WP were included in group A. In group B, were included patients with high TG but not WP. Group C consisted of patients with WP but not high TG...
2018: Immunity & Ageing: I & A
https://read.qxmd.com/read/29971434/association-of-coffee-drinking-with-mortality-by-genetic-variation-in-caffeine-metabolism-findings-from-the-uk-biobank
#8
Erikka Loftfield, Marilyn C Cornelis, Neil Caporaso, Kai Yu, Rashmi Sinha, Neal Freedman
Importance: Prospective cohorts in North America, Europe, and Asia show consistent inverse associations between coffee drinking and mortality, including deaths from cardiovascular disease and some cancers. However, concerns about coffee, particularly among people with common genetic polymorphisms affecting caffeine metabolism and among those drinking more than 5 cups per day, remain. Objective: To evaluate associations of coffee drinking with mortality by genetic caffeine metabolism score...
August 1, 2018: JAMA Internal Medicine
https://read.qxmd.com/read/30019767/polyunsaturated-fatty-acids-for-the-primary-and-secondary-prevention-of-cardiovascular-disease
#9
REVIEW
Asmaa S Abdelhamid, Nicole Martin, Charlene Bridges, Julii S Brainard, Xia Wang, Tracey J Brown, Sarah Hanson, Oluseyi F Jimoh, Sarah M Ajabnoor, Katherine Ho Deane, Fujian Song, Lee Hooper
BACKGROUND: Evidence on the health effects of total polyunsaturated fatty acids (PUFA) is equivocal. Fish oils are rich in omega-3 PUFA and plant oils in omega-6 PUFA. Evidence suggests that increasing PUFA-rich foods, supplements or supplemented foods can reduce serum cholesterol, but may increase body weight, so overall cardiovascular effects are unclear. OBJECTIVES: To assess effects of increasing total PUFA intake on cardiovascular disease and all-cause mortality, lipids and adiposity in adults...
July 18, 2018: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30094804/high-methionine-low-folate-and-low-vitamin-b6-b12-hm-lf-lv-diet-causes-neurodegeneration-and-subsequent-short-term-memory-loss
#10
Mohammed Nuru, Nino Muradashvili, Anuradha Kalani, David Lominadze, Neetu Tyagi
Methionine is an essential amino acid found in rich quantities in average American diet such as meats, fish and eggs. Excessive consumption of such food often exceeds the normal requirement of the methionine in our body; which found to be related to the development of neurodegenerative disorders. However, the mechanistic pathways of methionine's influence on the brain are unclear. The present study is focus on the effects of high methionine, low folate and low vitamin B6/B12 (HM-LF-LV) diet on the dysfunction of neuronal and vascular specific markers in the brain...
December 2018: Metabolic Brain Disease
https://read.qxmd.com/read/30019765/omega-6-fats-for-the-primary-and-secondary-prevention-of-cardiovascular-disease
#11
REVIEW
Lee Hooper, Lena Al-Khudairy, Asmaa S Abdelhamid, Karen Rees, Julii S Brainard, Tracey J Brown, Sarah M Ajabnoor, Alex T O'Brien, Lauren E Winstanley, Daisy H Donaldson, Fujian Song, Katherine Ho Deane
BACKGROUND: Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated. OBJECTIVES: To assess effects of increasing omega-6 fats (linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid (DGLA) and arachidonic acid (AA)) on CVD and all-cause mortality. SEARCH METHODS: We searched CENTRAL, MEDLINE and Embase to May 2017 and clinicaltrials...
July 18, 2018: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/29930142/atherosclerosis-and-inflammation-overview-and-updates
#12
REVIEW
Glaucylara Reis Geovanini, Peter Libby
The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis and its complications has gained considerable attention, but has not yet entered clinical practice. Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. The recognition of atherogenesis as an active process rather than a cholesterol storage disease or a repository of calcium has highlighted some key inflammatory mechanisms. For example, mononuclear phagocytes contribute to all stages of this disease, illustrating the link between inflammation and atherosclerosis...
June 29, 2018: Clinical Science (1979-)
https://read.qxmd.com/read/29935936/unmet-need-for-adjunctive-dyslipidemia-therapy-in-hypertriglyceridemia-management
#13
REVIEW
Om P Ganda, Deepak L Bhatt, R Preston Mason, Michael Miller, William E Boden
Despite the important role of high-intensity statins in reducing atherosclerotic cardiovascular disease events in secondary and primary prevention, substantial residual risk persists, particularly among high-risk patients with type 2 diabetes mellitus, metabolic syndrome, and obesity. Considerable attention is currently directed to the role that elevated triglycerides (TGs) and non-high-density lipoprotein cholesterol levels play as important mediators of residual atherosclerotic cardiovascular disease risk, which is further strongly supported by genetic linkage studies...
July 17, 2018: Journal of the American College of Cardiology
https://read.qxmd.com/read/29957236/the-role-of-nutraceuticals-in-statin-intolerant-patients
#14
REVIEW
Maciej Banach, Angelo Maria Patti, Rosaria Vincenza Giglio, Arrigo F G Cicero, Atanas G Atanasov, Gani Bajraktari, Eric Bruckert, Olivier Descamps, Dragan M Djuric, Marat Ezhov, Zlatko Fras, Stephan von Haehling, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, G B John Mancini, Dimitri P Mikhailidis, Olena Mitchenko, Patrick M Moriarty, Paul Muntner, Dragana Nikolic, Demosthenes B Panagiotakos, Gyorgy Paragh, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Giuseppe M C Rosano, Robert S Rosenson, Jacek Rysz, Amirhossein Sahebkar, Maria-Corina Serban, Dragos Vinereanu, Michal Vrablík, Gerald F Watts, Nathan D Wong, Manfredi Rizzo
Statins are the most common drugs administered for patients with cardiovascular disease. However, due to statin-associated muscle symptoms, adherence to statin therapy is challenging in clinical practice. Certain nutraceuticals, such as red yeast rice, bergamot, berberine, artichoke, soluble fiber, and plant sterols and stanols alone or in combination with each other, as well as with ezetimibe, might be considered as an alternative or add-on therapy to statins, although there is still insufficient evidence available with respect to long-term safety and effectiveness on cardiovascular disease prevention and treatment...
July 3, 2018: Journal of the American College of Cardiology
https://read.qxmd.com/read/28616955/niacin-for-primary-and-secondary-prevention-of-cardiovascular-events
#15
REVIEW
Stefan Schandelmaier, Matthias Briel, Ramon Saccilotto, Kelechi K Olu, Armon Arpagaus, Lars G Hemkens, Alain J Nordmann
BACKGROUND: Nicotinic acid (niacin) is known to decrease LDL-cholesterol, and triglycerides, and increase HDL-cholesterol levels. The evidence of benefits with niacin monotherapy or add-on to statin-based therapy is controversial. OBJECTIVES: To assess the effectiveness of niacin therapy versus placebo, administered as monotherapy or add-on to statin-based therapy in people with or at risk of cardiovascular disease (CVD) in terms of mortality, CVD events, and side effects...
June 14, 2017: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/29785957/associations-of-egg-consumption-with-cardiovascular-disease-in-a-cohort-study-of-0-5-million-chinese-adults
#16
Chenxi Qin, Jun Lv, Yu Guo, Zheng Bian, Jiahui Si, Ling Yang, Yiping Chen, Yonglin Zhou, Hao Zhang, Jianjun Liu, Junshi Chen, Zhengming Chen, Canqing Yu, Liming Li
OBJECTIVE: To examine the associations between egg consumption and cardiovascular disease (CVD), ischaemic heart disease (IHD), major coronary events (MCE), haemorrhagic stroke as well as ischaemic stroke. METHODS: During 2004-2008, over 0.5 million adults aged 30-79 years were recruited from 10 diverse survey sites in China. Participants were asked about the frequency of egg consumption and were followed up via linkages to multiple registries and active investigation...
November 2018: Heart: Official Journal of the British Cardiac Society
https://read.qxmd.com/read/29773586/seafood-long-chain-n-3-polyunsaturated-fatty-acids-and-cardiovascular-disease-a-science-advisory-from-the-american-heart-association
#17
REVIEW
Eric B Rimm, Lawrence J Appel, Stephanie E Chiuve, Luc Djoussé, Mary B Engler, Penny M Kris-Etherton, Dariush Mozaffarian, David S Siscovick, Alice H Lichtenstein
Since the 2002 American Heart Association scientific statement "Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease," evidence from observational and experimental studies and from randomized controlled trials continues to emerge to further substantiate the beneficial effects of seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease. A recent American Heart Association science advisory addressed the specific effect of n-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events...
July 3, 2018: Circulation
https://read.qxmd.com/read/29755576/cold-pressed-minke-whale-oil-reduces-circulating-ldl-vldl-cholesterol-lipid-oxidation-and-atherogenesis-in-apolipoprotein-e-deficient-mice-fed-a-western-type-diet-for-13-weeks
#18
Mari Johannessen Walquist, Svein Kristian Stormo, Bjarne Østerud, Edel O Elvevoll, Karl-Erik Eilertsen
Background: Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed more pronounced beneficial effects on cardiovascular disease markers from intake of CWO compared to intake of CLO in human intervention studies. Extracts from CWO deprived of fatty acids have also been shown to display antioxidative and anti-inflammatory effects in vitro...
2018: Nutrition & Metabolism
https://read.qxmd.com/read/29627296/relationship-between-lipoprotein-subfraction-cholesterol-and-residual-risk-for-cardiovascular-outcomes-a-post-hoc-analysis-of-the-aim-high-trial
#19
Peter P Toth, Steven R Jones, April Slee, Jerome Fleg, Santica M Marcovina, Megan Lacy, Ruth McBride, William E Boden
BACKGROUND: The AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial failed to demonstrate incremental clinical benefit of extended-release niacin (ERN) in 3414 statin-treated patients with established cardiovascular (CV) disease who had low baseline levels of high-density lipoprotein cholesterol (HDL-C) as compared to placebo. A previous secondary analysis suggested that ERN provided outcome benefits in ERN-treated patients with high triglycerides (TGs; >200 mg/dL) and very low HDL-C (<32 mg/dL) at baseline...
May 2018: Journal of Clinical Lipidology
https://read.qxmd.com/read/29277442/plasma-levels-of-n-3-fatty-acids-and-risk-of-coronary-heart-disease-among-japanese-the-japan-public-health-center-based-jphc-study
#20
Kei Hamazaki, Hiroyasu Iso, Ehab S Eshak, Satoyo Ikehara, Ai Ikeda, Motoki Iwasaki, Tomohito Hamazaki, Shoichiro Tsugane
BACKGROUND AND AIMS: Higher intake of fish or n-3 polyunsaturated fatty acids (PUFAs) has been associated with reduced risk of coronary heart disease (CHD). However, it is unclear whether increased blood levels of n-3 PUFAs are associated with reduced risk of CHD in the Japanese population. METHODS: The relationship between circulating levels of n-3 PUFAs (eicosapentaenoic acid + docosapentaenoic acid + docosahexaenoic acid) and risk of CHD was examined in a nested case-control study among participants in the Japan Public Health Center (JPHC)-based Study Cohort...
May 2018: Atherosclerosis
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