Tinka Bakker, Ameen Abu-Hanna, Dave A Dongelmans, Wytze J Vermeijden, Rob J Bosman, Dylan W de Lange, Joanna E Klopotowska, Nicolette F de Keizer, S Hendriks, J Ten Cate, P F Schutte, D van Balen, M Duyvendak, A Karakus, M Sigtermans, E M Kuck, N G M Hunfeld, H van der Sijs, P W de Feiter, E-J Wils, P E Spronk, H J M van Kan, M S van der Steen, I M Purmer, B E Bosma, H Kieft, R J van Marum, E de Jonge, A Beishuizen, K Movig, F Mulder, E J F Franssen, W M van den Bergh, W Bult, M Hoeksema, E Wesselink
PURPOSE: Potential drug-drug interactions (pDDIs) may harm patients admitted to the Intensive Care Unit (ICU). Due to the patient's critical condition and continuous monitoring on the ICU, not all pDDIs are clinically relevant. Clinical decision support systems (CDSSs) warning for irrelevant pDDIs could result in alert fatigue and overlooking important signals. Therefore, our aim was to describe the frequency of clinically relevant pDDIs (crpDDIs) to enable tailoring of CDSSs to the ICU setting...
April 2021: Journal of Critical Care