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Drug safety

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67 papers 25 to 100 followers
By Oswaldo Vargas Health system pharmacist currently working on Medication Safety as a part of Patient Safety work task force group
Teresa Bellón
Cutaneous adverse drug reactions are unpredictable and include various different skin conditions of varying degrees of severity. The most concerning are usually referred to as severe cutaneous adverse reactions (SCARs) and include acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DiHS) or hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). All are delayed type IV hypersensitivity reactions in which a T-cell-mediated drug-specific immune response is responsible for causing the disease...
April 24, 2019: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Ebenezer Kwabena Tetteh
Consumption of quality-assured medicines is expected to maintain or improve population health. Yet in a number of situations, what is realized is lower health benefits or magnified safety risks. Recognizing the public health implications of safety risks or medication-related harm, and that some types of harm are avoidable, the World Health Organization has initiated the third Global Patient Safety challenge on Medication Safety. Under the term "Medication Without Harm", this Challenge aims to assess the scope and nature of avoidable medication-related harm, create a framework for intervention and develop national guidance and tools to support safer medication use...
April 5, 2019: Research in Social & Administrative Pharmacy: RSAP
Tyler A Vest, Nicholas P Gazda, Daniel H Schenkat, Stephen F Eckel
PURPOSE: This article identifies, prioritizes, and summarizes published literature on the medication use process (MUP) from calendar year 2017 that can impact health-system pharmacists' daily practice. The MUP is the foundational system that provides the framework for safe medication use within the health care environment. The MUP is defined in this article as having the following components: prescribing/transcribing, dispensing, administration, and monitoring. Articles that evaluated one of the steps were gauged for their usefulness toward daily practice change...
April 1, 2019: American Journal of Health-system Pharmacy: AJHP
Adam S Darwich, Lisa von Moltke
No abstract text is available yet for this article.
March 21, 2019: Clinical Pharmacology and Therapeutics
Jin Niu, Robert M Straubinger, Donald E Mager
Pharmacodynamic drug-drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms are frequently misused. Within a complex pathophysiological system, the mechanism of interaction may occur at the same target or through alternate pathways. Quantitative evaluation of pharmacodynamic DDIs by employing modeling and simulation approaches is needed to identify and optimize safe and effective combination therapy regimens...
March 26, 2019: Clinical Pharmacology and Therapeutics
Koby Cohen, Abraham Weizman, Aviv Weinstein
Cannabis is the most popular illicit drug in the Western world. Repeated cannabis use has been associated with short and long-term side effects including respiratory and cardiovascular disorders, cognitive alterations, psychosis, schizophrenia and mood disorders. However, casual relations between cannabis use and these adverse effects are missing. On the other hand, recent research proposed promising therapeutic potential of cannabinoid-based drugs for a wide range of medical conditions including neurological and psychiatric disorders...
January 31, 2019: Clinical Pharmacology and Therapeutics
Van D Tran, Valeria V Dorofeeva, Ekaterina E Loskutova
Objective: The purpose of this study is to develop and validate the psychometric properties of a scale for measuring the quality of patient medication counseling by using the Rasch model. Methods: In this study, the scale was developed based on the literature review. It consisted of 31 items across five subscales: introduction, problem identification, content, behavior, and conclusion. A convenient sample of community pharmacists was recruited from four major cities in Vietnam: Hanoi, Da Nang, Ho Chi Minh, and Can Tho...
October 2018: Pharmacy Practice
Ruth Kinston, Niamh McCarville, Andrew Hassell
BACKGROUND: Medical doctors are required to prescribe drugs safely and effectively upon qualification, a skill that many feel poorly prepared to undertake. To better prepare doctors, a whole-task approach that develops knowledge and skills, but that also considers the effect of the complex clinical workplace on prescribing, is optimal. We describe an evaluation of an experiential learning programme that allows senior medical students to gain experience with inpatient prescribing during their hospital assistantship...
January 7, 2019: Clinical Teacher
Ornella Moreno-Mattar, Rosana Ramírez, Andrés Alvarado, Francisco Sierra, Javier Guzmán
BACKGROUND: The Colombian National Food and Drug Surveillance Institute (INVIMA) is responsible for monitoring the safety and efficacy of medicines circulating the Colombian market. DISCUSSION: This article summarizes the three key strategies the institution has implemented to strengthen the National Pharmacovigilance Program: improving the interaction and working relationship with regional health authorities, expanding the National Pharmacovigilance Network and implementing the electronic submission of adverse events...
2019: Current Drug Safety
Justin Gatwood, Kenneth C Hohmeier, Ian M Brooks
OBJECTIVE: To describe opportunities for pharmacists to use mobile messaging and real-time monitoring to engage with patients taking long-term medications. SUMMARY: The proliferation of mobile phone use across the United States has been met with increased application of these devices by the medical community. However, beyond simple text messages and app-based functions, use of these devices by pharmacies and pharmacists has not been leveraged to improve patient outcomes, such as medication adherence...
November 14, 2018: Journal of the American Pharmacists Association: JAPhA
Victoria C Ziesenitz, Erin Fox, Mark Zocchi, Samira Samiee-Zafarghandy, Johannes N van den Anker, Maryann Mazer-Amirshahi
BACKGROUND: Prescription drug shortages have increased significantly during the past two decades and also impact drugs used in critical care and pediatrics. OBJECTIVES: To analyze drug shortages affecting medications used in neonatal intensive care units (NICUs). METHODS: Drug shortage data for the top 100 NICU drugs were retrieved from the University of Utah Drug Information Service from 2001 to 2016. Data were analyzed focusing on drug class, formulation, reason for shortage, and shortage duration...
2019: Neonatology
Natalia C Duarte, Cristina R Barbosa, Mariane Gr Tavares, Lara P Dias, Rafael N Souza, Patricia Moriel
Management and prevention of problems related to oncology drugs are particularly important due to the excessive cost, high toxicity, and narrow therapeutic index of the antineoplastic drugs, in addition to the patients' state of health. Therefore, the presence of the pharmacist as a member of the multidisciplinary team is essential to contribute to patient safety. In this work, the interventions performed were identified, quantified, and classified to characterize the work of the clinical oncology pharmacist...
October 22, 2018: Journal of Oncology Pharmacy Practice
Vivien C Abad, Christian Guilleminault
Chronic insomnia affects 57% of the elderly in the United States, with impairment of quality of life, function, and health. Chronic insomnia burdens society with billions of dollars in direct and indirect costs of care. The main modalities in the treatment of insomnia in the elderly are psychological/behavioral therapies, pharmacological treatment, or a combination of both. Various specialty societies view psychological/behavioral therapies as the initial treatment intervention. Pharmacotherapy plays an adjunctive role when insomnia symptoms persist or when patients are unable to pursue cognitive behavioral therapies...
September 2018: Drugs & Aging
Molly Billstein-Leber, Col Jorge D Carrillo, Angela T Cassano, Kym Moline, Jennifer J Robertson
No abstract text is available yet for this article.
October 1, 2018: American Journal of Health-system Pharmacy: AJHP
Sandra L Kane-Gill
No abstract text is available yet for this article.
August 2018: Pharmacotherapy
Izabela C Leahy, Meghan Lavoie, David Zurakowski, Amanda W Baier, Robert M Brustowicz
STUDY OBJECTIVE: The objective of the study was to: a) characterize the frequency, type, and outcome of anesthetic medication errors spanning an 8.5-year period, b) describe the targeted error reduction strategies and c) measure the effects, if any, of a focused, continuous, multifaceted Medication Safety Program. DESIGN: Retrospective analysis. SETTING: All anesthetizing locations (57). PATIENTS: All anesthesia patients at all Boston Children's Hospital anesthetizing locations from January 2008 to June 2016 were included...
September 2018: Journal of Clinical Anesthesia
Estela R García, Stefanie Thalhauser, Hèctor R Loscertales, Pilar Modamio, Cecilia F Lastra, Eduardo L Mariño
As the elderly population and polypharmacy are increasing, it is predicted that interventions to enhance medication adherence, as dose administration aids (DAA), will grow. One of the limitations of repackaging medicines into DAA is to assure the stability of medicines, and, therefore, their quality, efficacy and safety. Area covered: This article collects and summarises data of all the stability studies of repackaged medicines into DAAs. Computerized search in databases: PubMed, Google Scholar, SciELO, and reference texts related to the field (keywords: drug stability, DAAs, compliance aids, and repackaging), open access databases and guidelines...
June 2018: Expert Opinion on Drug Delivery
Anne M Euser, Catrien G Reichart, Ingrid D C van Balkom
No abstract text is available yet for this article.
October 2017: Therapeutic Advances in Drug Safety
Gemma Donovan, Lindsay Parkin, Lyn Brierley-Jones, Scott Wilkes
OBJECTIVES: There is widespread use of unlicensed medicines within primary and secondary care but little information is available around how these medicines are used. This analysis examines and evaluates the content and quality of relevant guidance documentation currently in use within the UK. METHODS: Guidance documents were identified through a literature search as well as email requests to pharmacy organisations throughout the UK. Unlicensed medicine documentation suitable for inclusion in the analysis underwent thematic analysis and quality assessment using the AGREE II tool...
January 30, 2018: International Journal of Pharmacy Practice
Brett Mensh, Konrad Kording
No abstract text is available yet for this article.
September 2017: PLoS Computational Biology
2018-01-13 15:56:56
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