collection
https://read.qxmd.com/read/37401966/diabetic-retinopathy-emerging-concepts-of-current-and-potential-therapy
#1
REVIEW
Muhammad Zulfiqah Sadikan, Nurul Alimah Abdul Nasir
Diabetic retinopathy (DR) is one of the leading causes of permanent central blindness worldwide. Despite the complexity and inadequate understanding of DR pathogenesis, many of the underlying pathways are currently partially understood and may offer potential targets for future treatments. Anti-VEGF medications are currently the main medication for this problem. This article provides an overview of the established pharmacological treatments and those that are being developed to cure DR. We firstly reviewed the widely utilized approaches including pan-retinal photocoagulation therapy, anti-VEGF therapy, corticosteroid therapy, and surgical management of DR...
December 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37636838/enhancing-self-medication-practices-in-the-era-of-infodemic-the-role-of-pharmacovigilance
#2
EDITORIAL
Carlos-Alberto Calderon-Ospina
No abstract text is available yet for this article.
2023: Therapeutic Advances in Drug Safety
https://read.qxmd.com/read/37780667/opportunities-and-challenges-of-pharmacovigilance-in-special-populations-a-narrative-review-of-the-literature
#3
REVIEW
Yanping Li, Yuanlin Wu, Tingting Jiang, Haiyan Xing, Jing Xu, Chen Li, Rui Ni, Ni Zhang, Guiyuan Xiang, Li Li, Ziwei Li, Lanlan Gan, Yao Liu
The relatively new discipline of pharmacovigilance (PV) aims to monitor the safety of drugs throughout their evolution and is essential to discovering new drug risks. Due to their specific and complex physiology, children, pregnant women, and elderly adults are more prone to adverse drug reactions (ADRs). Additionally, the lack of clinical trial data exacerbates the challenges faced with pharmacotherapy in these populations. Elderly patients tend to have multiple comorbidities often requiring more extensive medication, which adds additional challenges for healthcare professionals (HCPs) in delivering safe and effective pharmacotherapy...
2023: Therapeutic Advances in Drug Safety
https://read.qxmd.com/read/37130140/dietary-supplements-and-medicinal-plants-in-urolithiasis-diet-prevention-and-cure
#4
REVIEW
Mitul Oswal, Ryan Varghese, Tanmay Zagade, Chetan Dhatrak, Rohit Sharma, Dileep Kumar
BACKGROUND: Urolithiasis has been a major health concern for centuries, primarily owing to the limited treatment options in the physician's armamentarium. However, various studies have underscored a lesser incidence of urolithiasis in cohorts predominantly consuming fruits and vegetables. This article aims to review various dietary plants, medicinal herbs and phytochemicals in the prevention and management of urolithiasis. METHODS: To provide context and evidence, relevant publications were identified on Google Scholar, PubMed and Science-Direct using keywords such as urolithiasis, nephrolithiasis, urolithiasis, renal stones, phytochemicals and dietary plants...
June 5, 2023: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/37566770/-adverse-drug-events-in-hospitalized-patients-prevalence-causes-and-risk-factors
#5
JOURNAL ARTICLE
María Del Rocío Hernández-Morales, Jorge Manuel Ramírez-Sánchez, Eleazar Mancilla-Hernández, Norma Lara-Dávalos, Samara Nazarala-Sánchez, Margarita Aguirre-Barbosa
OBJECTIVE: To determine prevalence, causes and risk factors of ADE in hospitalized patients of a General Hospital. METHODS: Observational and analytical case-control study, carried out in patients hospitalized for adverse drug events, treated at the Hospital General Dr. Eduardo Vázquez N, in Puebla, Mexico, between, June 2019 to June 2021. For the statistical analysis, percentages, frequencies, means, odds ratio, χ2, and multiple binary logistic regression were used...
June 28, 2023: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://read.qxmd.com/read/36125022/mobile-apps-for-quick-adverse-drug-reaction-report-a-scoping-review
#6
REVIEW
Edna Ribeiro Parracha, Ana Margarida Advinha, Manuel José Lopes, Sofia Oliveira-Martins
PURPOSE: Spontaneous notification systems are essential in a post-marketing safety context. However, using this method, only about 6% of all adverse drug reactions are notified. To overcome this sub-notification problem, new methods need to be developed to improve and facilitate reporting. In this sense, the use of digital media, mainly medical mobile apps, has been presented as a powerful tool, including in pharmacovigilance. We performed a scope review to identify the available apps used to report adverse drug reactions around the world to eventually identify which of them best fits the Portuguese pharmacovigilance system...
January 2023: Pharmacoepidemiology and Drug Safety
https://read.qxmd.com/read/35959503/associated-factors-of-potential-drug-drug-interactions-and-drug-food-interactions-in-patients-with-multiple-sclerosis
#7
JOURNAL ARTICLE
Jane Louisa Debus, Paula Bachmann, Niklas Frahm, Pegah Mashhadiakbar, Silvan Elias Langhorst, Barbara Streckenbach, Julia Baldt, Felicita Heidler, Michael Hecker, Uwe Klaus Zettl
BACKGROUND: Multiple sclerosis (MS) is the most common immune-mediated demyelinating disease in younger adults. Patients with MS (PwMS) are vulnerable to the presence of potential drug-drug interactions (pDDIs) and potential drug-food interactions (pDFIs) as they take numerous medications to treat MS, associated symptoms and comorbidities. Knowledge about pDDIs and pDFIs can increase treatment success and reduce side effects. OBJECTIVE: We aimed at determining the frequency and severity of pDDIs and pDFIs in PwMS, with regard to polypharmacy...
2022: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/35273009/drug-induced-acute-kidney-injury
#8
REVIEW
Mark A Perazella, Mitchell H Rosner
Medications are a common cause of AKI, especially for patients admitted to hospital wards and the intensive care unit. Although drug-related kidney injury occurs through different mechanisms, this review will focus on three specific types of tubulointerstitial injury. Direct acute tubular injury develops from several medications, which are toxic to various cellular functions. Their excretory pathways through the proximal tubules contribute further to AKI. Drug-induced AKI may also develop through induction of inflammation within the tubulointerstitium...
August 2022: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/34621456/pharmacists-roles-in-mental-healthcare-past-present-and-future
#9
JOURNAL ARTICLE
Sarira El-Den, Jack C Collins, Timothy F Chen, Claire L O'reilly
Mental illnesses cause significant disease burden globally, with medicines being a major modality of treatment for most mental illnesses. Pharmacists are accessible and trusted healthcare professionals who have an important role in supporting people living with mental illness. This commentary discusses the role of pharmacists in mental healthcare, as part of multidisciplinary teams, the current evidence to support these roles, and the training, remuneration and policy changes needed to recognize these roles and embed pharmacists as core members of the mental healthcare team...
2021: Pharmacy Practice
https://read.qxmd.com/read/34331675/smart-safety-surveillance-3s-multi-country-experience-of-implementing-the-3s-concepts-and-principles
#10
JOURNAL ARTICLE
Noha Iessa, Viola Macolic Sarinic, Lilit Ghazaryan, Naira Romanova, Asnakech Alemu, Watcharee Rungapiromnan, Porntip Jiamsuchon, Pattreya Pokhagul, Jose Luis Castro, Diego Macias Saint-Gerons, Gayane Ghukasyan, Mengistab Teferi, Madhur Gupta, Shanthi Narayan Pal
INTRODUCTION: The Smart Safety Surveillance (3S) concept is based on the understanding that, when faced with competing pharmacovigilance priorities, countries will have to invest judiciously, by focusing on new priority products, sharing work and resources with other countries when possible and building national competence for those activities that cannot be delegated. METHOD: The 3S principles were applied to Armenia, Brazil, Ethiopia, India, Peru and Thailand using three priority products: bedaquiline, rotavirus vaccine and tafenoquine...
October 2021: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/34196229/medication-adherence-in-bipolar-disorder-exploring-the-role-of-predominant-polarity
#11
JOURNAL ARTICLE
Sutanuka Ghosal, Nitu Mallik, Rudraprasad Acharya, Gargi Dasgupta, Dilip Kumar Mondal, Arghya Pal
OBJECTIVES: Medication non-adherence is one important reason behind sub-optimal outcome from treatment of bipolar affective disorder (BPAD). Though various reasons behind medication non-adherence have been identified, little is known about the medication adherence patterns across various predominant polarities (PP) in BPAD. METHODS: 100 euthymic patients of BPAD were purposively recruited and the PP were determined. Subsequently, Morisky Medication adherence scale (MMAS); Global Assessment of Functioning (GAF); Oslo Social Support Scale and World Health Organization Quality of Life scale- Brief version (WHOQOL-Bref) were administered...
July 1, 2021: International Journal of Psychiatry in Medicine
https://read.qxmd.com/read/33904111/a-multi-modal-approach-to-evaluate-the-impact-of-risk-evaluation-and-mitigation-strategy-rems-programs
#12
JOURNAL ARTICLE
Ameet Sarpatwari, Mayookha Mitra-Majumdar, Katsiaryna Bykov, Jerry Avorn, Steven Woloshin, Gita A Toyserkani, Cynthia LaCivita, Claudia Manzo, Esther H Zhou, Ellen Pinnow, Gerald J Dal Pan, Joshua J Gagne, Krista F Huybrechts, William B Feldman, Kristyn Chin, Aaron S Kesselheim
INTRODUCTION: Since 2007, the US Food and Drug Administration has had the authority to require risk evaluation and mitigation strategy (REMS) programs for certain medications with serious safety concerns to help ensure the benefits of the medication outweigh its risks. Such programs can include requirements for patient monitoring, restrictions on dispensing or administration, and physician and pharmacy training and certification. However, there has been only scattered evidence on the impact of REMS programs on informed decision making, medication access, or patient outcomes...
April 27, 2021: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/33687517/quality-efficacy-safety-it-is-not-enough
#13
JOURNAL ARTICLE
Silvio Garattini
There is a need of comparative studies to understand the differences in term of efficacy and safety of drugs with different mechanisms of action but similar therapeutic indications. This requires changes in the European Legislation of criteria for drug approval.
September 2021: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/33383285/a-missing-piece-fracture-of-peripheral-intravenous-cannula-a-case-report
#14
Masawa K Nyamuryekung'e, Elizabeth E Mmari, Miten R Patel
INTRODUCTION AND IMPORTANCE: Peripheral venous cannulation is the most common procedure, often performed by junior colleagues. Despite its benign nature, it is associated with extravascular infiltration, thrombophlebitis, hematoma, catheter-associated bloodstream infections, trauma to surrounding structures, including tendon and nerve injures, hematoma formation and air embolism. Fracture of a peripheral intravenous cannula in situ is a rare, potentially serious complication that is underreported...
January 2021: International Journal of Surgery Case Reports
https://read.qxmd.com/read/33352505/clinically-relevant-potential-drug-drug-interactions-in-intensive-care-patients-a-large-retrospective-observational-multicenter-study
#15
MULTICENTER STUDY
Tinka Bakker, Ameen Abu-Hanna, Dave A Dongelmans, Wytze J Vermeijden, Rob J Bosman, Dylan W de Lange, Joanna E Klopotowska, Nicolette F de Keizer, S Hendriks, J Ten Cate, P F Schutte, D van Balen, M Duyvendak, A Karakus, M Sigtermans, E M Kuck, N G M Hunfeld, H van der Sijs, P W de Feiter, E-J Wils, P E Spronk, H J M van Kan, M S van der Steen, I M Purmer, B E Bosma, H Kieft, R J van Marum, E de Jonge, A Beishuizen, K Movig, F Mulder, E J F Franssen, W M van den Bergh, W Bult, M Hoeksema, E Wesselink
PURPOSE: Potential drug-drug interactions (pDDIs) may harm patients admitted to the Intensive Care Unit (ICU). Due to the patient's critical condition and continuous monitoring on the ICU, not all pDDIs are clinically relevant. Clinical decision support systems (CDSSs) warning for irrelevant pDDIs could result in alert fatigue and overlooking important signals. Therefore, our aim was to describe the frequency of clinically relevant pDDIs (crpDDIs) to enable tailoring of CDSSs to the ICU setting...
April 2021: Journal of Critical Care
https://read.qxmd.com/read/33162396/glucocorticoids-surprising-new-findings-on-their-mechanisms-of-actions
#16
EDITORIAL
Frank Buttgereit
No abstract text is available yet for this article.
February 2021: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/32789821/e-learning-in-pharmacovigilance-an-evaluation-of-microlearning-based-modules-developed-by-uppsala-monitoring-centre
#17
JOURNAL ARTICLE
Anna Hegerius, Pia Caduff-Janosa, Ruth Savage, Johan Ellenius
INTRODUCTION: An increasing global need for pharmacovigilance training cannot be met with classroom courses alone. Several e-learning modules have been developed by Uppsala Monitoring Centre (UMC). With distance learners and technological challenges such as poor internet bandwidth to be considered, UMC opted for the microlearning approach based on small learning units connected to specific learning objectives. The aim of this study was to evaluate how this e-learning course was received...
November 2020: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/32584935/efficacy-and-safety-of-ursodeoxycholic-acid-for-the-prevention-of-gallstone-formation-after-gastrectomy-in-patients-with-gastric-cancer-the-pegasus-d-randomized-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Sang Hyub Lee, Dong Kee Jang, Moon-Won Yoo, Sun-Hwi Hwang, Seong-Yeob Ryu, Oh Kyoung Kwon, Hoon Hur, Hong Man Yoon, Bang Wool Eom, Hye Seong Ahn, Taeil Son, Kyo Young Song, Han Hong Lee, Min-Gew Choi, Ji Yeong An, Sang-Il Lee, Kyung Ho Lee, Soyeon Ahn, Young Suk Park, Do Joong Park
IMPORTANCE: The incidence of gallstones has been reported to increase after gastrectomy. However, few studies have been conducted on the prevention of gallstone formation in patients who have undergone gastrectomy. OBJECTIVE: To evaluate the efficacy and safety of ursodeoxycholic acid (UDCA) in preventing gallstone formation after gastrectomy in patients with gastric cancer. DESIGN, SETTING, AND PARTICIPANTS: The PEGASUS-D study (Efficacy and Safety of DWJ1319 in the Prevention of Gallstone Formation after Gastrectomy in Patient with Gastric Cancer: A Multicenter, Randomized, Double-blind, Placebo-controlled Study) was a randomized, double-blind, placebo-controlled clinical trial conducted at 12 institutions in the Republic of Korea...
August 1, 2020: JAMA Surgery
https://read.qxmd.com/read/32439654/low-dose-aspirin-for-prevention-of-pre-eclampsia-when-over-the-counter-just-isn-t
#19
EDITORIAL
Joanna Girling
No abstract text is available yet for this article.
July 2020: Drug and Therapeutics Bulletin
https://read.qxmd.com/read/32363948/the-safety-of-medications-used-to-treat-peripheral-neuropathic-pain-part-1-antidepressants-and-antiepileptics-review-of-double-blind-placebo-controlled-randomized-clinical-trials
#20
JOURNAL ARTICLE
Marie Selvy, Mélissa Cuménal, Nicolas Kerckhove, Christine Courteix, Jérôme Busserolles, David Balayssac
INTRODUCTION: Peripheral neuropathic pain is a highly disabling condition for patients and a challenge for neurologists and pain physicians. Although many drugs have been assessed in scientific studies, few have demonstrated a clear clinical efficacy against neuropathic pain. Moreover, the paucity of data regarding their safety raised the question on the benefit-risk ratio when used in patients experiencing peripheral neuropathies. AREAS COVERED: The authors conducted a review of double-blind, placebo-controlled, randomized clinical trials to assess the safety of medications used to treat neuropathic pain...
June 2020: Expert Opinion on Drug Safety
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