Ivana V Yang, Brent S Pedersen, Einat Rabinovich, Corinne E Hennessy, Elizabeth J Davidson, Elissa Murphy, Brenda Juan Guardela, John R Tedrow, Yingze Zhang, Mandal K Singh, Mick Correll, Marvin I Schwarz, Mark Geraci, Frank C Sciurba, John Quackenbush, Avrum Spira, Naftali Kaminski, David A Schwartz
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is an untreatable and often fatal lung disease that is increasing in prevalence and is caused by complex interactions between genetic and environmental factors. Epigenetic mechanisms control gene expression and are likely to regulate the IPF transcriptome. OBJECTIVES: To identify methylation marks that modify gene expression in IPF lung. METHODS: We assessed DNA methylation (comprehensive high-throughput arrays for relative methylation arrays [CHARM]) and gene expression (Agilent gene expression arrays) in 94 patients with IPF and 67 control subjects, and performed integrative genomic analyses to define methylation-gene expression relationships in IPF lung...
December 1, 2014: American Journal of Respiratory and Critical Care Medicine