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Repetative Transcranial Magnetic Stimulation

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11 papers 25 to 100 followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
Usha K Misra, Jayantee Kalita, Sanjeev K Bhoi
Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for pain but there is no class 1 study on its role in migraine prophylaxis. In this study we report the efficacy and safety of high-rate rTMS in migraine prophylaxis. Adult migraine patients having >4 attacks/month were randomized to high-rate rTMS or sham stimulation. Stimulation in the form of 10 Hz rTMS, 600 pulses in 10 trains were delivered to the hot spot of the right abductor digiti minimi in 412 s. Three sessions were delivered on alternate days...
November 2013: Journal of Neurology
Bradley V Watts, Barbara Landon, Alicia Groft, Yinong Young-Xu
BACKGROUND: Posttraumatic stress disorder (PTSD) is a commonly occurring and often debilitating psychiatric condition. There currently is not definitive information regarding the efficacy of repetitive transcranial magnetic stimulation (rTMS) for PTSD. OBJECTIVE: This study seeks to examine the efficacy of rTMS for PTSD. METHODS: Twenty subjects with PTSD were randomly assigned to receive either 10 rTMS sessions delivered at 1 Hz to the right dorsolateral prefrontal cortex (DLPRC) or 10 sham rTMS sessions to the same area...
January 2012: Brain Stimulation
Liane Young, Joan Albert Camprodon, Marc Hauser, Alvaro Pascual-Leone, Rebecca Saxe
When we judge an action as morally right or wrong, we rely on our capacity to infer the actor's mental states (e.g., beliefs, intentions). Here, we test the hypothesis that the right temporoparietal junction (RTPJ), an area involved in mental state reasoning, is necessary for making moral judgments. In two experiments, we used transcranial magnetic stimulation (TMS) to disrupt neural activity in the RTPJ transiently before moral judgment (experiment 1, offline stimulation) and during moral judgment (experiment 2, online stimulation)...
April 13, 2010: Proceedings of the National Academy of Sciences of the United States of America
Mouhsin M Shafi, M Brandon Westover, Lindsay Oberman, Sydney S Cash, Alvaro Pascual-Leone
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique that utilizes magnetic fluxes to alter cortical activity. Continuous theta-burst repetitive TMS (cTBS) results in long-lasting decreases in indices of cortical excitability, and alterations in performance of behavioral tasks. We investigated the effects of cTBS on cortical function via functional connectivity and graph theoretical analysis of EEG data. Thirty-one channel resting-state EEG recordings were obtained before and after 40 s of cTBS stimulation to the left primary motor cortex...
January 2014: Brain Topography
Jussi Tallus, Pantelis Lioumis, Heikki Hämäläinen, Seppo Kähkönen, Olli Tenovuo
Mild traumatic brain injury (mTBI) may cause diffuse damage to the brain, especially to the frontal areas, that may lead to persistent symptoms. We studied participants with past mTBI by means of navigated transcranial magnetic stimulation (nTMS) combined with electroencephalography (EEG). Eleven symptomatic and 8 recovered participants with a history of single mTBI and 9 healthy controls participated. Average time from injury to testing was 5 years. The participants did not have abnormalities or signs of injury on brain magnetic resonance imaging, and they did not use any centrally acting medication...
July 15, 2013: Journal of Neurotrauma
Angel V Peterchev, Timothy A Wagner, Pedro C Miranda, Michael A Nitsche, Walter Paulus, Sarah H Lisanby, Alvaro Pascual-Leone, Marom Bikson
BACKGROUND: The growing use of transcranial electric and magnetic (EM) brain stimulation in basic research and in clinical applications necessitates a clear understanding of what constitutes the dose of EM stimulation and how it should be reported. METHODS: This paper provides fundamental definitions and principles for reporting of dose that encompass any transcranial EM brain stimulation protocol. RESULTS: The biologic effects of EM stimulation are mediated through an electromagnetic field injected (via electric stimulation) or induced (via magnetic stimulation) in the body...
October 2012: Brain Stimulation
Nora Weiduschat, Alexander Thiel, Ilona Rubi-Fessen, Alexander Hartmann, Josef Kessler, Patrick Merl, Lutz Kracht, Thomas Rommel, Wolf Dieter Heiss
BACKGROUND AND PURPOSE: Although functional imaging studies suggest that recruitment of contralesional areas hinders optimal functional reorganization in patients with aphasic stroke, only limited evidence is available on the efficacy of noninvasive brain stimulation such as repetitive transcranial magnetic stimulation aimed at suppression of contralateral overactivation. METHODS: In this randomized, controlled, blinded pilot study, the effect of 1-Hz repetitive transcranial magnetic stimulation over right-hemispheric Broca homolog in subjects with poststroke aphasia in the subacute stage was examined...
February 2011: Stroke; a Journal of Cerebral Circulation
Tsung-Hsun Hsieh, Ying-Zu Huang, Alexander Rotenberg, Alvaro Pascual-Leone, Yung-Hsiao Chiang, Jia-Yi Wang, Jia-Jin J Chen
Repetitive magnetic stimulation (rTMS), including theta burst stimulation (TBS), is capable of modulating motor cortical excitability through plasticity-like mechanisms and might have therapeutic potential for Parkinson's disease (PD). An animal model would be helpful for elucidating the mechanism of rTMS that remain unclear and controversial. Here, we have established a TMS model in rat and applied this model to study the impact of substantia nigra dopamine neuron on TBS-induced motor plasticity in PD rats...
July 2015: Cerebral Cortex
Marcelo T Berlim, Frederique Van den Eynde, Z Jeff Daskalakis
Clinical trials on low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) over the right dorsolateral prefrontal cortex have yielded conflicting evidence concerning its overall efficacy for treating major depression (MD). As this may have been the result of limited statistical power of individual trials, we have carried the present systematic review and meta-analysis to examine this issue. We searched the literature for English language randomized, double-blind and sham-controlled trials (RCTs) on LF-rTMS for treating MD from 1995 through July 2012 using EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, SCOPUS, and ProQuest Dissertations & Theses, and from October 2008 until July 2012 using MEDLINE...
March 2013: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Edda Bilek, Axel Schäfer, Elisabeth Ochs, Christine Esslinger, Maria Zangl, Michael M Plichta, Urs Braun, Peter Kirsch, Thomas G Schulze, Marcella Rietschel, Andreas Meyer-Lindenberg, Heike Tost
Neural plasticity is crucial for understanding the experience-dependent reorganization of brain regulatory circuits and the pathophysiology of schizophrenia. An important circuit-level feature derived from functional magnetic resonance imaging (fMRI) is prefrontal-hippocampal seeded connectivity during working memory, the best established intermediate connectivity phenotype of schizophrenia risk to date. The phenotype is a promising marker for the effects of plasticity-enhancing interventions, such as high-frequency repetitive transcranial magnetic stimulation (rTMS), and can be studied in healthy volunteers in the absence of illness-related confounds, but the relationship to brain plasticity is unexplored...
April 17, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Wen-Hsu Sung, Chih-Pin Wang, Chen-Liang Chou, Yi-Cheng Chen, Yue-Cune Chang, Po-Yi Tsai
BACKGROUND AND PURPOSE: Although there has been extensive research on the effectiveness of repetitive transcranial magnetic stimulation (rTMS) to improve patients' motor performance after experiencing chronic stroke, explicit findings on the coupling of different rTMS protocols are meager. We designed this sham-controlled randomized study to investigate the potential for a consecutive suppressive-facilitatory TMS protocol to improve motor outcomes after chronic stroke. METHODS: Fifty-four chronic hemiplegic stroke patients were allocated across 4 groups to undergo 20 daily sessions of (1) 1 Hz rTMS over the contralesional primary motor cortex (M1) and then intermittent theta burst stimulation over the ipsilesional M1 (group A); (2) contralesional sham stimulation and then ipsilesional real intermittent theta burst stimulation (group B); (3) contralesional real 1 Hz rTMS and then ipsilesional sham stimulation (group C); or (4) bilateral sham-control procedures (group D)...
May 2013: Stroke; a Journal of Cerebral Circulation
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