collection
https://read.qxmd.com/read/25256128/in-transit-melanoma-metastases-incidence-prognosis-and-the-role-of-lymphadenectomy
#21
JOURNAL ARTICLE
Rebecca L Read, Lauren Haydu, Robyn P M Saw, Michael J Quinn, Kerwin Shannon, Andrew J Spillane, Jonathan R Stretch, Richard A Scolyer, John F Thompson
PURPOSE: To analyze a large, single-institution database to further understanding of melanoma in-transit metastases (ITM) with regard to incidence, prognosis, and the role of lymphadenectomy. METHODS: A total of 11,614 patients with single primary cutaneous melanomas were treated at Melanoma Institute Australia between January 1994 and December 2009. Of these, 505 developed ITM. Clinicopathologic characteristics, sentinel node (SN) status, patterns of disease progression, and outcomes were analyzed...
February 2015: Annals of Surgical Oncology
https://read.qxmd.com/read/25245968/unusual-presentations-of-melanoma-melanoma-of-unknown-primary-site-melanoma-arising-in-childhood-and-melanoma-arising-in-the-eye-and-on-mucosal-surfaces
#22
REVIEW
Vernon K Sondak, Jane L Messina
Most melanomas present as primary tumors on the skin surface in adults; however, melanomas also arise in the eye and on the mucosal surfaces or present as apparently metastatic disease without any known history of a cutaneous primary. Melanoma is also being diagnosed during childhood more frequently than ever. Surgeons need to be aware of and understand these unusual presentations of melanoma to optimally manage their patients.
October 2014: Surgical Clinics of North America
https://read.qxmd.com/read/25245963/surviving-cutaneous-melanoma-a-clinical-review-of-follow-up-practices-surveillance-and-management-of-recurrence
#23
REVIEW
Amy A Mrazek, Celia Chao
The number of melanoma survivors in the United States continues to steadily increase 2.6% per year, while death rates have remained stable over time. Although controversy exists regarding optimal surveillance strategies, recommendations for clinical monitoring are based on tumor stage, tumor phenotype, likelihood of recurrence, prognosis, risk factors, psychosocial impact of disease, and patient well-being. Management guidelines for recurrent disease depend on the type of recurrence: local, satellite/in-transit, regional, or distant metastasis...
October 2014: Surgical Clinics of North America
https://read.qxmd.com/read/25236319/melanoma-of-the-glans-penis-successfully-treated-with-topical-imiquimod-dermoscopy-usefulness-in-clinical-monitoring-and-review-of-the-literature
#24
REVIEW
Massimiliano Scalvenzi, Franco Palmisano, Daniela Russo, Massimo Mascolo, Claudia Costa
Melanoma in situ (MIS) of the penis is very rare in dermatologic literature. The standard of care for MIS is surgical removal by excision with a 5-mm margins or Mohs micrographic surgery. Nevertheless, surgery is occasionally not feasible for a number of reasons, such as patient comorbidities, potential aesthetic and functional impairment and patient preference. Recently, topical treatment with an immunomodulator, imiquimod, has been proposed as an alternative treatment for MIS. Dermoscopy, beyond its well established usefulness in the diagnostic evaluation of melanocytic lesions, has also shown to be an important tool in monitoring therapeutic response to various dermatoses...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://read.qxmd.com/read/25207376/ultraviolet-radiation-and-cutaneous-malignant-melanoma
#25
REVIEW
Johan Emilian Moan, Zivile Baturaite, Arne Dahlback, Alina Carmen Porojnicu
Essential features of the epidemiology and photobiology of cutaneous malignant melanoma (CMM) in Norway were studied in comparison with data from countries at lower latitudes. Arguments for and against a relationship between ultraviolet radiation (UV) from sun and artificial light and CMM are discussed. Our data indicate that UV is a carcinogen for CMM and that intermittent exposures are notably melanomagenic. This hypothesis was supported both by latitude gradients, by time trends and by changing patterns of tumor density on different body localizations...
2014: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/25207375/solar-ultraviolet-exposure-and-mortality-from-skin-tumors
#26
REVIEW
Marianne Berwick, Claire Pestak, Nancy Thomas
Solar UV radiation (UVR) exposure is clearly associated with increased mortality from nonmelanoma skin cancer--usually squamous cell carcinoma. However, the association with cutaneous melanoma is unclear from the evidence in ecologic studies and several analytic studies have conflicting results regarding the effect of high levels of intermittent UV exposure prior to diagnosis on mortality. Understanding this conundrum is critical to present coherent public health messages and to improve the mortality rates from melanoma...
2014: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/25205351/conjonctival-melanoma-metastatic-to-the-breast-a-case-report
#27
JOURNAL ARTICLE
Saoussane Kharmoum, Mesmoudi Mohamed, Hafida Benhammane, Jinane Kharmoum, Salima Touri, Khadija Setti, Youssef Bensouda, Saber Boutayeb, Ibrahim Elghissassi, Hind Mrabti, Bassma El Khannoussi, Yassir Sbitti, Hassan Errihani
BACKGROUND: Breast metastasis is fairly uncommon and prognosis is dismal. Breast metastasis might be the first symptom or may occur during the course of other malignancies dominantly arising from the contralateral breast. Leukemia, lung cancer and conjunctival melanoma may spread to the breast. CASE PRESENTATION: A 43-year-old female patient was operated on for conjunctival melanoma. After two years the disease progressed quickly and cutaneous nodes appeared on the back and paraumbilical region...
2014: BMC Research Notes
https://read.qxmd.com/read/25188058/dermatopathology-sy07-2-subungual-melanocytic-lesions
#28
JOURNAL ARTICLE
Dong-Youn Lee
Subungual melanocytic lesions usually present with melanonychia. Melanonychia is defined as a brown or black pigmentation on a fingernail or toenail. Melanonychia, which is caused by melanin production in the nail matrix, appears as a longitudinal band. Longitudinal melanonychia is caused by nail matrix nevus, nail matrix lentigo, and an activation of the nail matrix melanocytes. Most importantly, longitudinal melanonychia may indicate an early stage of subungual melanoma.Subungual melanoma is a rare subtype of melanoma that usually originates and spreads from the nail matrix...
October 2014: Pathology
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