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Oppositional Defiant Disorder

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8 papers 25 to 100 followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
Atilla Turgay
Oppositional defiant disorder (ODD) consists of an enduring pattern of uncooperative, defiant and hostile behaviour toward authority figures that does not involve major antisocial violations and is not accounted for by the developmental stage of the child. The rate of ODD in children and adolescents in the general population has been reported to be between 2% and 16%. The International Classification of Diseases 10th Revision (ICD-10) classifies ODD as a mild form of conduct disorder (CD), and it has been estimated that up to 60% of patients with ODD will develop CD...
2009: CNS Drugs
James Signorovitch, M Haim Erder, Jipan Xie, Vanja Sikirica, Mei Lu, Paul S Hodgkins, Eric Q Wu
OBJECTIVES: To illustrate a matching-adjusted indirect comparison by comparing the efficacy of guanfacine extended release (GXR) and atomoxetine (ATX) in reducing oppositional symptoms in children with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder. METHODS: Individual patient data were used from a GXR trial; only published summary data were used from ATX trials. In a matching-adjusted indirect comparison, individual patients from the GXR trial were weighted such that their mean baseline characteristics matched those published for ATX trials...
May 2012: Pharmacoepidemiology and Drug Safety
Dustin A Pardini, Paula J Fite
OBJECTIVE: The incremental utility of symptoms of conduct disorder (CD), oppositional defiant disorder (ODD), attention-deficit/hyperactivity disorder (ADHD), and callous-unemotional (CU) traits for predicting psychosocial outcomes across multiple domains was examined in a community sample of 1,517 boys. METHOD: Several outcomes were assessed semiannually across a 2-year follow-up, including antisocial behavior, internalizing problems, peer conflict, and academic difficulties...
November 2010: Journal of the American Academy of Child and Adolescent Psychiatry
Kenneth D Gadow, L Eugene Arnold, Brooke S G Molina, Robert L Findling, Oscar G Bukstein, Nicole V Brown, Nora K McNamara, E Victoria Rundberg-Rivera, Xiaobai Li, Heidi L Kipp, Jayne Schneider, Cristan A Farmer, Jennifer L Baker, Joyce Sprafkin, Robert R Rice, Srihari S Bangalore, Eric M Butter, Kristin A Buchan-Page, Elizabeth A Hurt, Adrienne B Austin, Sabrina N Grondhuis, Michael G Aman
OBJECTIVE: In this study, we aimed to expand on our prior research into the relative efficacy of combining parent training, stimulant medication, and placebo (Basic therapy) versus parent training, stimulant, and risperidone (Augmented therapy) by examining treatment effects for attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD) symptoms and peer aggression, symptom-induced impairment, and informant discrepancy. METHOD: Children (6-12 years of age; N = 168) with severe physical aggression, ADHD, and co-occurring ODD/CD received an open trial of parent training and stimulant medication for 3 weeks...
September 2014: Journal of the American Academy of Child and Adolescent Psychiatry
Paul J Frick, Joel T Nigg
This review evaluates the diagnostic criteria for three of the most common disorders for which children and adolescents are referred for mental health treatment: attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD). Although research supports the validity and clinical utility of these disorders, several issues are highlighted that could enhance the current diagnostic criteria. For ADHD, defining the core features of the disorder and its fit with other disorders, enhancing the validity of the criteria through the lifespan, considering alternative ways to form subtypes of the disorder, and modifying the age-of-onset criterion are discussed relative to the current diagnostic criteria...
2012: Annual Review of Clinical Psychology
Vanja Sikirica, Robert L Findling, James Signorovitch, M Haim Erder, Ryan Dammerman, Paul Hodgkins, Mei Lu, Jipan Xie, Eric Q Wu
BACKGROUND: No head-to-head clinical trials have been published comparing guanfacine extended release (GXR) and atomoxetine (ATX): two nonstimulants approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, other study designs or methods could be used to indirectly compare these two medications. Matching-adjusted indirect comparison (MAIC) is a recent methodology that utilizes individual patient data (IPD) from clinical trials for one treatment and published aggregate data from another treatment to estimate the relative efficacy of both, providing rapid, reliable comparative efficacy results...
November 2013: CNS Drugs
Jeffrey H Newcorn, Mark A Stein, Ann C Childress, Sharon Youcha, Carla White, Gail Enright, Jonathan Rubin
OBJECTIVE: To examine the efficacy and tolerability of guanfacine extended release (GXR) administered in the morning or evening in children with attention-deficit/hyperactivity disorder (ADHD). METHOD: In this multicenter, double-blind, placebo-controlled, dose-optimization study, children 6 to 12 years of age with ADHD were randomized to receive GXR (1-4 mg/d) in the morning and placebo in the evening (GXR am), placebo in the morning and GXR in the evening (GXR pm), or twice-daily placebo...
September 2013: Journal of the American Academy of Child and Adolescent Psychiatry
Kurt P Schulz, Suzanne M Clerkin, Jin Fan, Jeffrey M Halperin, Jeffrey H Newcorn
RATIONALE: Functional interactions between limbic regions that process emotions and frontal networks that guide response functions provide a substrate for emotional cues to influence behavior. Stimulation of postsynaptic α₂ adrenoceptors enhances the function of prefrontal regions in these networks. However, the impact of this stimulation on the emotional biasing of behavior has not been established. OBJECTIVES: This study tested the effect of the postsynaptic α₂ adrenoceptor agonist guanfacine on the emotional biasing of response execution and inhibition in prefrontal cortex...
March 2013: Psychopharmacology
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