Timothy J Ley, Christopher Miller, Li Ding, Benjamin J Raphael, Andrew J Mungall, A Gordon Robertson, Katherine Hoadley, Timothy J Triche, Peter W Laird, Jack D Baty, Lucinda L Fulton, Robert Fulton, Sharon E Heath, Joelle Kalicki-Veizer, Cyriac Kandoth, Jeffery M Klco, Daniel C Koboldt, Krishna-Latha Kanchi, Shashikant Kulkarni, Tamara L Lamprecht, David E Larson, Ling Lin, Charles Lu, Michael D McLellan, Joshua F McMichael, Jacqueline Payton, Heather Schmidt, David H Spencer, Michael H Tomasson, John W Wallis, Lukas D Wartman, Mark A Watson, John Welch, Michael C Wendl, Adrian Ally, Miruna Balasundaram, Inanc Birol, Yaron Butterfield, Readman Chiu, Andy Chu, Eric Chuah, Hye-Jung Chun, Richard Corbett, Noreen Dhalla, Ranabir Guin, An He, Carrie Hirst, Martin Hirst, Robert A Holt, Steven Jones, Aly Karsan, Darlene Lee, Haiyan I Li, Marco A Marra, Michael Mayo, Richard A Moore, Karen Mungall, Jeremy Parker, Erin Pleasance, Patrick Plettner, Jacquie Schein, Dominik Stoll, Lucas Swanson, Angela Tam, Nina Thiessen, Richard Varhol, Natasja Wye, Yongjun Zhao, Stacey Gabriel, Gad Getz, Carrie Sougnez, Lihua Zou, Mark D M Leiserson, Fabio Vandin, Hsin-Ta Wu, Frederick Applebaum, Stephen B Baylin, Rehan Akbani, Bradley M Broom, Ken Chen, Thomas C Motter, Khanh Nguyen, John N Weinstein, Nianziang Zhang, Martin L Ferguson, Christopher Adams, Aaron Black, Jay Bowen, Julie Gastier-Foster, Thomas Grossman, Tara Lichtenberg, Lisa Wise, Tanja Davidsen, John A Demchok, Kenna R Mills Shaw, Margi Sheth, Heidi J Sofia, Liming Yang, James R Downing, Greg Eley
BACKGROUND: Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear. METHODS: We analyzed the genomes of 200 clinically annotated adult cases of de novo AML, using either whole-genome sequencing (50 cases) or whole-exome sequencing (150 cases), along with RNA and microRNA sequencing and DNA-methylation analysis. RESULTS: AML genomes have fewer mutations than most other adult cancers, with an average of only 13 mutations found in genes...
May 30, 2013: New England Journal of Medicine