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Internal Medicine

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36 papers 100 to 500 followers
By Ronald Lands Benign hematologist
Anna L Godfrey, Peter J Campbell, Cathy MacLean, Georgina Buck, Julia Cook, Julie Temple, Bridget S Wilkins, Keith Wheatley, Jyoti Nangalia, Jacob Grinfeld, Mary Frances McMullin, Cecily Forsyth, Jean-Jacques Kiladjian, Anthony R Green, Claire N Harrison
Purpose Cytoreductive therapy is beneficial in patients with essential thrombocythemia (ET) at high risk of thrombosis. However, its value in those lacking high-risk features remains unknown. This open-label, randomized trial compared hydroxycarbamide plus aspirin with aspirin alone in patients with ET age 40 to 59 years and without high-risk factors or extreme thrombocytosis. Patients and Methods Patients were age 40 to 59 years and lacked a history of ischemia, thrombosis, embolism, hemorrhage, extreme thrombocytosis (platelet count ≥ 1,500 × 109 /L), hypertension, or diabetes requiring therapy...
August 28, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Marco P Donadini, Marta Bellesini, Alessandro Squizzato
Clinical Question: Among patients at high risk for or with established cardiovascular disease (ie, history of peripheral artery disease, stroke, or coronary artery disease without a coronary stent), is the addition of clopidogrel to aspirin associated with lower risk of mortality and cardiovascular events compared with aspirin alone? Bottom Line: Clopidogrel plus aspirin is associated with a reduced risk for myocardial infarction and ischemic stroke and an increased risk for major bleeding compared with aspirin alone among patients at high risk for or with an established cardiovascular disease but without a coronary stent...
August 14, 2018: JAMA: the Journal of the American Medical Association
David J Elpern
No abstract text is available yet for this article.
January 2002: Archives of Dermatology
Liselotte N Dyrbye, Prathibha Varkey, Sonja L Boone, Daniel V Satele, Jeff A Sloan, Tait D Shanafelt
OBJECTIVE: To explore the work lives, professional satisfaction, and burnout of US physicians by career stage and differences across sexes, specialties, and practice setting. PARTICIPANTS AND METHODS: We conducted a cross-sectional study that involved a large sample of US physicians from all specialty disciplines in June 2011. The survey included the Maslach Burnout Inventory and items that explored professional life and career satisfaction. Physicians who had been in practice 10 years or less, 11 to 20 years, and 21 years or more were considered to be in early, middle, and late career, respectively...
December 2013: Mayo Clinic Proceedings
Robin T Bigelow, Yevgeniy R Semenov, Sascha du Lac, Howard J Hoffman, Yuri Agrawal
BACKGROUND/AIMS: Patients with vestibular disease have been observed to have concomitant cognitive and psychiatric dysfunction. We evaluated the association between vestibular vertigo, cognitive impairment and psychiatric conditions in a nationally representative sample of US adults. METHODS: We performed a cross-sectional analysis using the 2008 National Health Interview Survey (NHIS), which included a Balance and Dizziness Supplement, and questions about cognitive function and psychiatric comorbidity...
April 2016: Journal of Neurology, Neurosurgery, and Psychiatry
L P Weiner
No abstract text is available yet for this article.
December 1997: Multiple Sclerosis: Clinical and Laboratory Research
Hugh J Willison, Bart C Jacobs, Pieter A van Doorn
Guillain-Barré syndrome is the most common and most severe acute paralytic neuropathy, with about 100,000 people developing the disorder every year worldwide. Under the umbrella term of Guillain-Barré syndrome are several recognisable variants with distinct clinical and pathological features. The severe, generalised manifestation of Guillain-Barré syndrome with respiratory failure affects 20-30% of cases. Treatment with intravenous immunoglobulin or plasma exchange is the optimal management approach, alongside supportive care...
August 13, 2016: Lancet
C Jacobs, M Clemons
No abstract text is available yet for this article.
August 2014: Current Oncology
Carl J Lavie, Duck-chul Lee, Xuemei Sui, Ross Arena, James H O'Keefe, Timothy S Church, Richard V Milani, Steven N Blair
Considerable evidence has established the link between high levels of physical activity (PA) and all-cause and cardiovascular disease (CVD)-specific mortality. Running is a popular form of vigorous PA that has been associated with better overall survival, but there is debate about the dose-response relationship between running and CVD and all-cause survival. In this review, we specifically reviewed studies published in PubMed since 2000 that included at least 500 runners and 5-year follow-up so as to analyze the relationship between vigorous aerobic PA, specifically running, and major health consequences, especially CVD and all-cause mortality...
November 2015: Mayo Clinic Proceedings
Bridget M Kuehn
No abstract text is available yet for this article.
December 15, 2015: JAMA: the Journal of the American Medical Association
Danijel Galun, Dragan Basaric, Marinko Zuvela, Predrag Bulajic, Aleksandar Bogdanovic, Nemanja Bidzic, Miroslav Milicevic
Hepatocellular carcinoma (HCC) is one of the major malignant diseases in many healthcare systems. The growing number of new cases diagnosed each year is nearly equal to the number of deaths from this cancer. Worldwide, HCC is a leading cause of cancer-related deaths, as it is the fifth most common cancer and the third most important cause of cancer related death in men. Among various risk factors the two are prevailing: viral hepatitis, namely chronic hepatitis C virus is a well-established risk factor contributing to the rising incidence of HCC...
September 18, 2015: World Journal of Hepatology
Vincent Wai-Sun Wong, Grace Lai-Hung Wong
No abstract text is available yet for this article.
February 13, 2016: Lancet
Nicholas J Talley, Alexander C Ford
No abstract text is available yet for this article.
November 5, 2015: New England Journal of Medicine
Suzanne Bertisch
This issue provides a clinical overview of restless legs syndrome, focusing on diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
November 3, 2015: Annals of Internal Medicine
Scott D Halpern
The disquieting patterns of end-of-life care in the United States have been well documented. In the last month of life, one in two Medicare beneficiaries visits an emergency department, one in three is admitted to an intensive care unit, and one in five has inpatient surgery. But one of the most..
November 19, 2015: New England Journal of Medicine
Andrew J Muir
PURPOSE: Cirrhosis and its related complications remain a prominent global health concern despite advances in understanding and treating the disorder. Early diagnosis and intervention strategies may reduce the impact of cirrhosis; however, it can be difficult for initial point-of-care health care providers to identify and refer patients with cirrhosis due to lack of knowledge and resources. This review examines current diagnostic strategies for cirrhosis and cirrhosis-related complications and the potential benefits of multidisciplinary care for patients with the disorder...
August 2015: Clinical Therapeutics
Monika M Safford
No abstract text is available yet for this article.
December 2015: Journal of General Internal Medicine
James C Watson, P James B Dyck
Peripheral neuropathy is one of the most prevalent neurologic conditions encountered by physicians of all specialties. Physicians are faced with 3 distinct challenges in caring for patients with peripheral neuropathy: (1) how to efficiently and effectively screen (in less than 2 minutes) an asymptomatic patient for peripheral neuropathy when they have a disorder in which peripheral neuropathy is highly prevalent (eg, diabetes mellitus), (2) how to clinically stratify patients presenting with symptoms of neuropathy to determine who would benefit from specialty consultation and what testing is appropriate for those who do not need consultation, and (3) how to treat the symptoms of painful peripheral neuropathy...
July 2015: Mayo Clinic Proceedings
Susan L Mitchell
New England Journal of Medicine, Volume 372, Issue 26, Page 2533-2540, June 2015.
June 25, 2015: New England Journal of Medicine
Mathieu Anheim, Christine Tranchant, Michel Koenig
No abstract text is available yet for this article.
February 16, 2012: New England Journal of Medicine
2015-08-05 09:21:05
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