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JOURNAL ARTICLE
Stefanie Klenke, Katharina Rump, Kai Buschkamp, Andrea Engler, Jürgen Peters, Winfried Siffert, Ulrich H Frey
The Gαq/-Gα11-PLCβ1 pathway is important for intracellular signalling and associated with pathological conditions, such as cardiac hypertrophy. The GNAQ and GNA11 promoters (encoding for Gαq and Gα11) have already been characterized and are both regulated by the transcription factor early growth response 1 (Egr-1). In contrast, the PLCB1 promoter (encoding for the direct downstream effector PLCβ1) has neither been cloned nor characterized. Therefore, the purpose of this study was to 1) characterize the PLCB1 promoter, and 2) assess its potential regulation by Egr-1...
November 5, 2014: European Journal of Pharmacology
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